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Family characteristics and life events before the onset of autoimmune type 1 diabetes in young adults - A nationwide study

Littorin, Bengt LU ; Björk, Elisabeth ; Sundkvist, Göran LU ; Blohme, Göran ; Nyström, Lennarth ; Bolinder, Jan ; Carlson, Anita ; Eriksson, Jan W. ; Landin-Olsson, Mona LU and Scherstén, Bengt LU , et al. (2001) In Diabetes Care 24(6). p.1033-1037
Abstract
OBJECTIVE - To elucidate whether family characteristics and stressful life events were associated with onset of autoimmune type 1 diabetes in young adults. RESEARCH DESIGN AND METHODS - This investigation was based on a nation-wide study (Diabetes Incidence Study in Sweden) of newly diagnosed patients aged 15-34 years. Patients clinically classified as type 1 diabetic with antibodies to islet cells and/or to GAD65 were compared with age- and sex-matched control subjects via questionnaire. The questionnaire covered diabetes heredity, social environment, educational level, and life events experienced during the 12 months before diagnosis. RESULTS - The rate of response was 82% for the diabetic patients and 65% for the control subjects.... (More)
OBJECTIVE - To elucidate whether family characteristics and stressful life events were associated with onset of autoimmune type 1 diabetes in young adults. RESEARCH DESIGN AND METHODS - This investigation was based on a nation-wide study (Diabetes Incidence Study in Sweden) of newly diagnosed patients aged 15-34 years. Patients clinically classified as type 1 diabetic with antibodies to islet cells and/or to GAD65 were compared with age- and sex-matched control subjects via questionnaire. The questionnaire covered diabetes heredity, social environment, educational level, and life events experienced during the 12 months before diagnosis. RESULTS - The rate of response was 82% for the diabetic patients and 65% for the control subjects. Questionnaires from 349 diabetic patients and 979 control subjects were considered. Diabetes in relatives was more frequent in the patients (odds ratio [OR]2.6) who were born in Sweden and whose mothers were of Swedish origin. No major stress factors were detected in the diabetic patients; however, in comparison with the control subjects, the diabetic patients had experienced fewer conflicts with their parents and had less often broken contacts with friends. CONCLUSIONS - Young adults with recent-onset type 1 diabetes were more exposed to heredity for diabetes, but no major prediabetic stress factors were detected. Our study does not directly support the concept that psychosocial stressful life events are involved in the development of autoimmune type 1 diabetes in young adults. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
24
issue
6
pages
1033 - 1037
publisher
American Diabetes Association
external identifiers
  • wos:000168962100012
  • scopus:0035380716
ISSN
1935-5548
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diabetes Epidemiology and Neuropathy (013241560), Medicine (Lund) (013230025), Department of Clinical Sciences, Malmö (013240000)
id
5eeb9070-a6c1-4cb1-8b6a-99a8068fb678 (old id 1119208)
alternative location
http://care.diabetesjournals.org/cgi/reprint/24/6/1033
date added to LUP
2016-04-01 15:24:45
date last changed
2022-01-28 05:10:46
@article{5eeb9070-a6c1-4cb1-8b6a-99a8068fb678,
  abstract     = {{OBJECTIVE - To elucidate whether family characteristics and stressful life events were associated with onset of autoimmune type 1 diabetes in young adults. RESEARCH DESIGN AND METHODS - This investigation was based on a nation-wide study (Diabetes Incidence Study in Sweden) of newly diagnosed patients aged 15-34 years. Patients clinically classified as type 1 diabetic with antibodies to islet cells and/or to GAD65 were compared with age- and sex-matched control subjects via questionnaire. The questionnaire covered diabetes heredity, social environment, educational level, and life events experienced during the 12 months before diagnosis. RESULTS - The rate of response was 82% for the diabetic patients and 65% for the control subjects. Questionnaires from 349 diabetic patients and 979 control subjects were considered. Diabetes in relatives was more frequent in the patients (odds ratio [OR]2.6) who were born in Sweden and whose mothers were of Swedish origin. No major stress factors were detected in the diabetic patients; however, in comparison with the control subjects, the diabetic patients had experienced fewer conflicts with their parents and had less often broken contacts with friends. CONCLUSIONS - Young adults with recent-onset type 1 diabetes were more exposed to heredity for diabetes, but no major prediabetic stress factors were detected. Our study does not directly support the concept that psychosocial stressful life events are involved in the development of autoimmune type 1 diabetes in young adults.}},
  author       = {{Littorin, Bengt and Björk, Elisabeth and Sundkvist, Göran and Blohme, Göran and Nyström, Lennarth and Bolinder, Jan and Carlson, Anita and Eriksson, Jan W. and Landin-Olsson, Mona and Scherstén, Bengt and Ostman, Jan and Wibell, Lars and Arnqvist, Hans J.}},
  issn         = {{1935-5548}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1033--1037}},
  publisher    = {{American Diabetes Association}},
  series       = {{Diabetes Care}},
  title        = {{Family characteristics and life events before the onset of autoimmune type 1 diabetes in young adults - A nationwide study}},
  url          = {{http://care.diabetesjournals.org/cgi/reprint/24/6/1033}},
  volume       = {{24}},
  year         = {{2001}},
}