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Follow-up of acute pyelonephritis in children by Tc-99m DMSA scintigraphy - Quantitative and qualitative assessment

Wallin, Lena; Helin, Ingemar and Bajc, Marika LU (2001) In Clinical Nuclear Medicine 26(5). p.423-432
Abstract
Purpose: The author's goal was to create a system to identify children at risk for development of progressive renal damage, Methods: Thirty-four children were examined with Tc-99m DMSA scintigraphy in the acute stage of an initial episode of pyelonephritis, after 6 months, and again after 1 year, The scintigraphic findings were correlated with clinical and laboratory data, Results: All children had parenchymal defects in the acute stage: 93% of the kidneys and 85% bilaterally, After 6 months, the defects had diminished or disappeared in 66% of the kidneys, New defects appeared in 22%, At 1 year, no further improvement was seen in the kidneys, with an improved or unchanged pattern at 6 months, New defects appeared in 34%, Mean kidney... (More)
Purpose: The author's goal was to create a system to identify children at risk for development of progressive renal damage, Methods: Thirty-four children were examined with Tc-99m DMSA scintigraphy in the acute stage of an initial episode of pyelonephritis, after 6 months, and again after 1 year, The scintigraphic findings were correlated with clinical and laboratory data, Results: All children had parenchymal defects in the acute stage: 93% of the kidneys and 85% bilaterally, After 6 months, the defects had diminished or disappeared in 66% of the kidneys, New defects appeared in 22%, At 1 year, no further improvement was seen in the kidneys, with an improved or unchanged pattern at 6 months, New defects appeared in 34%, Mean kidney activity uptake expressed as the percentage of administered dose (KU/AD), was low in the acute stage, increased at 6 months, with no further significant increase at 1 year, Eighty-three percent of children with urine cultures growing greater than or equal to 10(4) bacteria/ml at follow-up had decreased KU/AD values, whereas all children with urine cultures growing < 10(4) bacteria/ml had increased KU/AD values. Conclusions: Quantitative assessment increases the sensitivity of Tc-99m DMSA scintigraphy. Follow-up with this method makes it possible to identify the children with decreasing renal tubular function who may be at risk for progressive renal damage, Moderate bacteria of 104 bacteria/ml urine is associated with deterioration of renal tubular function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute Pyelonephritis, Bacteruria, Tc-99m DMSA Scintigraphy
in
Clinical Nuclear Medicine
volume
26
issue
5
pages
423 - 432
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000168298400010
  • scopus:0035028898
ISSN
0363-9762
language
English
LU publication?
yes
id
b573f1ac-3cd4-4de9-8544-0aba7a606830 (old id 1119283)
date added to LUP
2008-07-17 10:49:10
date last changed
2018-01-07 05:52:04
@article{b573f1ac-3cd4-4de9-8544-0aba7a606830,
  abstract     = {Purpose: The author's goal was to create a system to identify children at risk for development of progressive renal damage, Methods: Thirty-four children were examined with Tc-99m DMSA scintigraphy in the acute stage of an initial episode of pyelonephritis, after 6 months, and again after 1 year, The scintigraphic findings were correlated with clinical and laboratory data, Results: All children had parenchymal defects in the acute stage: 93% of the kidneys and 85% bilaterally, After 6 months, the defects had diminished or disappeared in 66% of the kidneys, New defects appeared in 22%, At 1 year, no further improvement was seen in the kidneys, with an improved or unchanged pattern at 6 months, New defects appeared in 34%, Mean kidney activity uptake expressed as the percentage of administered dose (KU/AD), was low in the acute stage, increased at 6 months, with no further significant increase at 1 year, Eighty-three percent of children with urine cultures growing greater than or equal to 10(4) bacteria/ml at follow-up had decreased KU/AD values, whereas all children with urine cultures growing &lt; 10(4) bacteria/ml had increased KU/AD values. Conclusions: Quantitative assessment increases the sensitivity of Tc-99m DMSA scintigraphy. Follow-up with this method makes it possible to identify the children with decreasing renal tubular function who may be at risk for progressive renal damage, Moderate bacteria of 104 bacteria/ml urine is associated with deterioration of renal tubular function.},
  author       = {Wallin, Lena and Helin, Ingemar and Bajc, Marika},
  issn         = {0363-9762},
  keyword      = {Acute Pyelonephritis,Bacteruria,Tc-99m DMSA Scintigraphy},
  language     = {eng},
  number       = {5},
  pages        = {423--432},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Clinical Nuclear Medicine},
  title        = {Follow-up of acute pyelonephritis in children by Tc-99m DMSA scintigraphy - Quantitative and qualitative assessment},
  volume       = {26},
  year         = {2001},
}