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A potential double role of anti-Lewis X antibodies in Helicobacter pylori-associated gastroduodenal diseases

Rudnicka, W.; Czkwianianc, E.; Planeta-Malecka, I.; Jurkiewicz, M.; Wisniewska, M.; Cieslikowski, T.; Rozalska, B.; Wadström, Torkel LU and Chmiela, M. (2001) In Pathogens and Disease 30(2). p.121-125
Abstract
In this study, we found Lewis X (Le(X)) determinants on 68% of Helicobacter pylori isolates from patients with chronic gastroduodenal diseases. Anti-Le(X) IgG were detected more frequently in the sera from dyspeptic children and adults (45 and 46%), with or without proved (culture) H. pylori infection, than in the sera from healthy individuals (14%, and 25%). In contrast, the prevalence of anti-Le(X) IgM was higher in the groups of healthy individuals than in the groups of dyspeptic patients. Moreover. anti-Le(X) monoclonal antibody of IgM class enhanced the uptake of Le(X)(+) but not Le(X)(-) H. pylori isolates by phagocytes. In the sera from some dyspeptic patients, we detected Le(X)-anti-Le(X) IgG immune complexes (Le(X) ICs). There was... (More)
In this study, we found Lewis X (Le(X)) determinants on 68% of Helicobacter pylori isolates from patients with chronic gastroduodenal diseases. Anti-Le(X) IgG were detected more frequently in the sera from dyspeptic children and adults (45 and 46%), with or without proved (culture) H. pylori infection, than in the sera from healthy individuals (14%, and 25%). In contrast, the prevalence of anti-Le(X) IgM was higher in the groups of healthy individuals than in the groups of dyspeptic patients. Moreover. anti-Le(X) monoclonal antibody of IgM class enhanced the uptake of Le(X)(+) but not Le(X)(-) H. pylori isolates by phagocytes. In the sera from some dyspeptic patients, we detected Le(X)-anti-Le(X) IgG immune complexes (Le(X) ICs). There was a great difference between children and adults as regards the presence of Le(X) ICs. The immune complexes were found in the sera from nine out of 29 (27%) H. pylori-infected and three out of eight (37%) uninfected adult dyspeptic patients. In comparison, Le(X)-anti-Le(X) IgG ICs were detected only for two out of 18 (11%) H. pylori-infected children. Le(X) ICs were not found in the sera from healthy individuals. Our results suggest that anti-Le(X) IgM may play a protective role in H. pylori infections. In contrast, anti-Le(X) IgG and particularly Le(X)-anti-Le(X) IgG ICs might contribute to the pathogenesis of chronic H. pylori infections. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Helicobacter pylori, Lewis X–anti-Lewis X immune complex, Lewis X
in
Pathogens and Disease
volume
30
issue
2
pages
121 - 125
publisher
Wiley-Blackwell
external identifiers
  • wos:000167748900007
  • scopus:0035068315
ISSN
2049-632X
DOI
10.1111/j.1574-695X.2001.tb01559.x
language
English
LU publication?
yes
id
3ce8a283-2926-4d11-99ec-71ac69ae60db (old id 1119380)
date added to LUP
2008-07-14 08:39:47
date last changed
2018-05-29 09:58:36
@article{3ce8a283-2926-4d11-99ec-71ac69ae60db,
  abstract     = {In this study, we found Lewis X (Le(X)) determinants on 68% of Helicobacter pylori isolates from patients with chronic gastroduodenal diseases. Anti-Le(X) IgG were detected more frequently in the sera from dyspeptic children and adults (45 and 46%), with or without proved (culture) H. pylori infection, than in the sera from healthy individuals (14%, and 25%). In contrast, the prevalence of anti-Le(X) IgM was higher in the groups of healthy individuals than in the groups of dyspeptic patients. Moreover. anti-Le(X) monoclonal antibody of IgM class enhanced the uptake of Le(X)(+) but not Le(X)(-) H. pylori isolates by phagocytes. In the sera from some dyspeptic patients, we detected Le(X)-anti-Le(X) IgG immune complexes (Le(X) ICs). There was a great difference between children and adults as regards the presence of Le(X) ICs. The immune complexes were found in the sera from nine out of 29 (27%) H. pylori-infected and three out of eight (37%) uninfected adult dyspeptic patients. In comparison, Le(X)-anti-Le(X) IgG ICs were detected only for two out of 18 (11%) H. pylori-infected children. Le(X) ICs were not found in the sera from healthy individuals. Our results suggest that anti-Le(X) IgM may play a protective role in H. pylori infections. In contrast, anti-Le(X) IgG and particularly Le(X)-anti-Le(X) IgG ICs might contribute to the pathogenesis of chronic H. pylori infections.},
  author       = {Rudnicka, W. and Czkwianianc, E. and Planeta-Malecka, I. and Jurkiewicz, M. and Wisniewska, M. and Cieslikowski, T. and Rozalska, B. and Wadström, Torkel and Chmiela, M.},
  issn         = {2049-632X},
  keyword      = {Helicobacter pylori,Lewis X–anti-Lewis X immune complex,Lewis X},
  language     = {eng},
  number       = {2},
  pages        = {121--125},
  publisher    = {Wiley-Blackwell},
  series       = {Pathogens and Disease},
  title        = {A potential double role of anti-Lewis X antibodies in Helicobacter pylori-associated gastroduodenal diseases},
  url          = {http://dx.doi.org/10.1111/j.1574-695X.2001.tb01559.x},
  volume       = {30},
  year         = {2001},
}