A potential double role of anti-Lewis X antibodies in Helicobacter pylori-associated gastroduodenal diseases
(2001) In Pathogens and Disease 30(2). p.121-125- Abstract
- In this study, we found Lewis X (Le(X)) determinants on 68% of Helicobacter pylori isolates from patients with chronic gastroduodenal diseases. Anti-Le(X) IgG were detected more frequently in the sera from dyspeptic children and adults (45 and 46%), with or without proved (culture) H. pylori infection, than in the sera from healthy individuals (14%, and 25%). In contrast, the prevalence of anti-Le(X) IgM was higher in the groups of healthy individuals than in the groups of dyspeptic patients. Moreover. anti-Le(X) monoclonal antibody of IgM class enhanced the uptake of Le(X)(+) but not Le(X)(-) H. pylori isolates by phagocytes. In the sera from some dyspeptic patients, we detected Le(X)-anti-Le(X) IgG immune complexes (Le(X) ICs). There was... (More)
- In this study, we found Lewis X (Le(X)) determinants on 68% of Helicobacter pylori isolates from patients with chronic gastroduodenal diseases. Anti-Le(X) IgG were detected more frequently in the sera from dyspeptic children and adults (45 and 46%), with or without proved (culture) H. pylori infection, than in the sera from healthy individuals (14%, and 25%). In contrast, the prevalence of anti-Le(X) IgM was higher in the groups of healthy individuals than in the groups of dyspeptic patients. Moreover. anti-Le(X) monoclonal antibody of IgM class enhanced the uptake of Le(X)(+) but not Le(X)(-) H. pylori isolates by phagocytes. In the sera from some dyspeptic patients, we detected Le(X)-anti-Le(X) IgG immune complexes (Le(X) ICs). There was a great difference between children and adults as regards the presence of Le(X) ICs. The immune complexes were found in the sera from nine out of 29 (27%) H. pylori-infected and three out of eight (37%) uninfected adult dyspeptic patients. In comparison, Le(X)-anti-Le(X) IgG ICs were detected only for two out of 18 (11%) H. pylori-infected children. Le(X) ICs were not found in the sera from healthy individuals. Our results suggest that anti-Le(X) IgM may play a protective role in H. pylori infections. In contrast, anti-Le(X) IgG and particularly Le(X)-anti-Le(X) IgG ICs might contribute to the pathogenesis of chronic H. pylori infections. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1119380
- author
- Rudnicka, W. ; Czkwianianc, E. ; Planeta-Malecka, I. ; Jurkiewicz, M. ; Wisniewska, M. ; Cieslikowski, T. ; Rozalska, B. ; Wadström, Torkel LU and Chmiela, M.
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Helicobacter pylori, Lewis X–anti-Lewis X immune complex, Lewis X
- in
- Pathogens and Disease
- volume
- 30
- issue
- 2
- pages
- 121 - 125
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000167748900007
- scopus:0035068315
- ISSN
- 2049-632X
- DOI
- 10.1111/j.1574-695X.2001.tb01559.x
- language
- English
- LU publication?
- yes
- id
- 3ce8a283-2926-4d11-99ec-71ac69ae60db (old id 1119380)
- date added to LUP
- 2016-04-01 11:55:57
- date last changed
- 2022-01-26 20:21:43
@article{3ce8a283-2926-4d11-99ec-71ac69ae60db, abstract = {{In this study, we found Lewis X (Le(X)) determinants on 68% of Helicobacter pylori isolates from patients with chronic gastroduodenal diseases. Anti-Le(X) IgG were detected more frequently in the sera from dyspeptic children and adults (45 and 46%), with or without proved (culture) H. pylori infection, than in the sera from healthy individuals (14%, and 25%). In contrast, the prevalence of anti-Le(X) IgM was higher in the groups of healthy individuals than in the groups of dyspeptic patients. Moreover. anti-Le(X) monoclonal antibody of IgM class enhanced the uptake of Le(X)(+) but not Le(X)(-) H. pylori isolates by phagocytes. In the sera from some dyspeptic patients, we detected Le(X)-anti-Le(X) IgG immune complexes (Le(X) ICs). There was a great difference between children and adults as regards the presence of Le(X) ICs. The immune complexes were found in the sera from nine out of 29 (27%) H. pylori-infected and three out of eight (37%) uninfected adult dyspeptic patients. In comparison, Le(X)-anti-Le(X) IgG ICs were detected only for two out of 18 (11%) H. pylori-infected children. Le(X) ICs were not found in the sera from healthy individuals. Our results suggest that anti-Le(X) IgM may play a protective role in H. pylori infections. In contrast, anti-Le(X) IgG and particularly Le(X)-anti-Le(X) IgG ICs might contribute to the pathogenesis of chronic H. pylori infections.}}, author = {{Rudnicka, W. and Czkwianianc, E. and Planeta-Malecka, I. and Jurkiewicz, M. and Wisniewska, M. and Cieslikowski, T. and Rozalska, B. and Wadström, Torkel and Chmiela, M.}}, issn = {{2049-632X}}, keywords = {{Helicobacter pylori; Lewis X–anti-Lewis X immune complex; Lewis X}}, language = {{eng}}, number = {{2}}, pages = {{121--125}}, publisher = {{Wiley-Blackwell}}, series = {{Pathogens and Disease}}, title = {{A potential double role of anti-Lewis X antibodies in Helicobacter pylori-associated gastroduodenal diseases}}, url = {{http://dx.doi.org/10.1111/j.1574-695X.2001.tb01559.x}}, doi = {{10.1111/j.1574-695X.2001.tb01559.x}}, volume = {{30}}, year = {{2001}}, }