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Increased blood-brain barrier permeability of morphine in a patient with severe brain lesions as determined by microdialysis

Bouw, R.; Ederoth, Per LU ; Lundberg, Johan LU ; Ungerstedt, U.; Nordström, Carl-Henrik LU and Hammarlund-Udenaes, M. (2001) In Acta Anaesthesiologica Scandinavica 45(3). p.390-392
Abstract
Intracerebral microdialysis was utilised to obtain information regarding how morphine is transported across the blood-brain barrier (BBB). In a patient with a severe brain injury, we measured simultaneously unbound extracellular fluid (ECF) concentrations of morphine in human brain and in subcutaneous fat tissue, which were compared to morphine levels in arterial blood. This report shows an increase in morphine levels near the trauma site in the brain compared to uninjured brain tissue. The half-life of morphine in uninjured and injured brain tissue of 178 min and 169 min, respectively, were comparable but were longer than in blood (64 min) and adipose tissue (63 min). This indicates that morphine is retained in brain tissue for a longer... (More)
Intracerebral microdialysis was utilised to obtain information regarding how morphine is transported across the blood-brain barrier (BBB). In a patient with a severe brain injury, we measured simultaneously unbound extracellular fluid (ECF) concentrations of morphine in human brain and in subcutaneous fat tissue, which were compared to morphine levels in arterial blood. This report shows an increase in morphine levels near the trauma site in the brain compared to uninjured brain tissue. The half-life of morphine in uninjured and injured brain tissue of 178 min and 169 min, respectively, were comparable but were longer than in blood (64 min) and adipose tissue (63 min). This indicates that morphine is retained in brain tissue for a longer time than what could be expected from the blood concentration-time profile. These results show the potential of the microdialysis technique in providing new information regarding the pharmacokinetics of drug in the human brain close to the trauma site and in macroscopically intact tissue. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Anaesthesiologica Scandinavica
volume
45
issue
3
pages
390 - 392
publisher
Wiley-Blackwell
external identifiers
  • wos:000167243900019
  • scopus:0035129778
ISSN
0001-5172
DOI
10.1034/j.1399-6576.2001.045003390.x
language
English
LU publication?
yes
id
10c974cc-07bb-4369-87d0-da99761b97f4 (old id 1119539)
date added to LUP
2008-06-25 13:25:24
date last changed
2018-03-11 03:33:58
@article{10c974cc-07bb-4369-87d0-da99761b97f4,
  abstract     = {Intracerebral microdialysis was utilised to obtain information regarding how morphine is transported across the blood-brain barrier (BBB). In a patient with a severe brain injury, we measured simultaneously unbound extracellular fluid (ECF) concentrations of morphine in human brain and in subcutaneous fat tissue, which were compared to morphine levels in arterial blood. This report shows an increase in morphine levels near the trauma site in the brain compared to uninjured brain tissue. The half-life of morphine in uninjured and injured brain tissue of 178 min and 169 min, respectively, were comparable but were longer than in blood (64 min) and adipose tissue (63 min). This indicates that morphine is retained in brain tissue for a longer time than what could be expected from the blood concentration-time profile. These results show the potential of the microdialysis technique in providing new information regarding the pharmacokinetics of drug in the human brain close to the trauma site and in macroscopically intact tissue.},
  author       = {Bouw, R. and Ederoth, Per and Lundberg, Johan and Ungerstedt, U. and Nordström, Carl-Henrik and Hammarlund-Udenaes, M.},
  issn         = {0001-5172},
  language     = {eng},
  number       = {3},
  pages        = {390--392},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Increased blood-brain barrier permeability of morphine in a patient with severe brain lesions as determined by microdialysis},
  url          = {http://dx.doi.org/10.1034/j.1399-6576.2001.045003390.x},
  volume       = {45},
  year         = {2001},
}