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BRCA2 mutation in a family with hereditary prostate cancer

Grönberg, Henrik; Åhman, Anna-Karin; Emanuelsson, Monica; Bergh, Anders; Damber, Jan-Erik and Borg, Åke LU (2001) In Genes, Chromosomes and Cancer 30(3). p.299-301
Abstract
Hereditary prostate cancer is a genetically heterogeneous disease, and so far four different susceptibility loci have been identified. Reports of associated cancers are few, and it is generally considered a sire-specific disease. However, some reports have shown an elevated risk for prostate cancer among BRCA2 mutation carriers. In this report, we present a family in which the father and four of his sons were diagnosed with prostate cancer at exceptionally early ages (51, 52, 56, 58, and 63 years, respectively). In addition, three daughters were diagnosed with breast cancer between the ages of 47 and 61. In this family, a truncating mutation in exon 11, 6051delA of the BRCA2 gene, leading to an early termination of the protein (codon... (More)
Hereditary prostate cancer is a genetically heterogeneous disease, and so far four different susceptibility loci have been identified. Reports of associated cancers are few, and it is generally considered a sire-specific disease. However, some reports have shown an elevated risk for prostate cancer among BRCA2 mutation carriers. In this report, we present a family in which the father and four of his sons were diagnosed with prostate cancer at exceptionally early ages (51, 52, 56, 58, and 63 years, respectively). In addition, three daughters were diagnosed with breast cancer between the ages of 47 and 61. In this family, a truncating mutation in exon 11, 6051delA of the BRCA2 gene, leading to an early termination of the protein (codon 1962), was identified. Although BRCA2 is probably responsible only for a very small fraction of hereditary prostate cancers, this finding supports previous reports of an increased risk of prostate cancer in BRCA2 mutation carriers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genes, Chromosomes and Cancer
volume
30
issue
3
pages
299 - 301
publisher
John Wiley & Sons
external identifiers
  • wos:000166849300011
  • scopus:0035150431
ISSN
1045-2257
DOI
10.1002/1098-2264(2000)9999:9999<::AID-GCC1090>3.0.CO;2-U
language
English
LU publication?
yes
id
d47bb5f4-f433-4d5e-a949-eb6337e9d51a (old id 1119678)
date added to LUP
2008-07-01 16:26:32
date last changed
2018-01-07 06:07:48
@article{d47bb5f4-f433-4d5e-a949-eb6337e9d51a,
  abstract     = {Hereditary prostate cancer is a genetically heterogeneous disease, and so far four different susceptibility loci have been identified. Reports of associated cancers are few, and it is generally considered a sire-specific disease. However, some reports have shown an elevated risk for prostate cancer among BRCA2 mutation carriers. In this report, we present a family in which the father and four of his sons were diagnosed with prostate cancer at exceptionally early ages (51, 52, 56, 58, and 63 years, respectively). In addition, three daughters were diagnosed with breast cancer between the ages of 47 and 61. In this family, a truncating mutation in exon 11, 6051delA of the BRCA2 gene, leading to an early termination of the protein (codon 1962), was identified. Although BRCA2 is probably responsible only for a very small fraction of hereditary prostate cancers, this finding supports previous reports of an increased risk of prostate cancer in BRCA2 mutation carriers.},
  author       = {Grönberg, Henrik and Åhman, Anna-Karin and Emanuelsson, Monica and Bergh, Anders and Damber, Jan-Erik and Borg, Åke},
  issn         = {1045-2257},
  language     = {eng},
  number       = {3},
  pages        = {299--301},
  publisher    = {John Wiley & Sons},
  series       = {Genes, Chromosomes and Cancer},
  title        = {BRCA2 mutation in a family with hereditary prostate cancer},
  url          = {http://dx.doi.org/10.1002/1098-2264(2000)9999:9999<::AID-GCC1090>3.0.CO;2-U},
  volume       = {30},
  year         = {2001},
}