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Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless

Baeg, Gyeong-Hun ; Lin, Xinhua ; Khare, Narmada ; Baumgartner, Stefan LU and Perrimon, Norbert (2001) In Development: For advances in developmental biology and stem cells 128(1). p.87-94
Abstract
Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene daily in this process. Here, we report the identification of another Drosophila glypican gene, daily-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activity implicates a function for DLY in Wg reception and we show that overexpression of DLY leads to an accumulation of extracellular Wg. We propose that DLY plays; a role in the extracellular distribution of Wg. Consistent with this model, a dramatic decrease of extracellular Wg was detected in clones of cells that are deficient in proper... (More)
Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene daily in this process. Here, we report the identification of another Drosophila glypican gene, daily-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activity implicates a function for DLY in Wg reception and we show that overexpression of DLY leads to an accumulation of extracellular Wg. We propose that DLY plays; a role in the extracellular distribution of Wg. Consistent with this model, a dramatic decrease of extracellular Wg was detected in clones of cells that are deficient in proper glycosaminoglycan biosynthesis. We conclude that HSPGs play an important role in organizing the extracellular distribution of Wg. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Drosophila melanogaster, Morphogen, HSPG, Wg signaling
in
Development: For advances in developmental biology and stem cells
volume
128
issue
1
pages
87 - 94
publisher
The Company of Biologists Ltd
external identifiers
  • wos:000166452100009
  • scopus:0035152025
ISSN
1477-9129
language
English
LU publication?
yes
id
162251f7-7d21-4b4a-b152-ecb2cb311963 (old id 1119707)
alternative location
http://dev.biologists.org/content/128/1/87.abstract
date added to LUP
2016-04-01 12:12:56
date last changed
2020-12-15 01:40:27
@article{162251f7-7d21-4b4a-b152-ecb2cb311963,
  abstract     = {Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene daily in this process. Here, we report the identification of another Drosophila glypican gene, daily-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activity implicates a function for DLY in Wg reception and we show that overexpression of DLY leads to an accumulation of extracellular Wg. We propose that DLY plays; a role in the extracellular distribution of Wg. Consistent with this model, a dramatic decrease of extracellular Wg was detected in clones of cells that are deficient in proper glycosaminoglycan biosynthesis. We conclude that HSPGs play an important role in organizing the extracellular distribution of Wg.},
  author       = {Baeg, Gyeong-Hun and Lin, Xinhua and Khare, Narmada and Baumgartner, Stefan and Perrimon, Norbert},
  issn         = {1477-9129},
  language     = {eng},
  number       = {1},
  pages        = {87--94},
  publisher    = {The Company of Biologists Ltd},
  series       = {Development: For advances in developmental biology and stem cells},
  title        = {Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless},
  url          = {http://dev.biologists.org/content/128/1/87.abstract},
  volume       = {128},
  year         = {2001},
}