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Islet autoantibodies in the prediction of diabetes in school children

Samuelsson, U.; Sundkvist, Göran LU ; Borg, Henrik LU ; Fernlund, Per LU and Ludvigsson, J. (2001) In Diabetes Research and Clinical Practice 51(1). p.51-57
Abstract
In 1987 serum was collected from 1031 non-diabetic schoolchildren in the Southeast area of Sweden with the aim of evaluating islet autoantibody status (ICA, GADA and IA2-ab) in the prediction of diabetes in schoolchildren. The clinical development of Type 1 diabetes in the children was assessed in 1994 and 1997. The combination of ICA, GADA and IA2-ab were found in four subjects whereas six had two and 35 children one of these antibodies. After 10 years, six of the 1031 children had developed clinical diabetes and five of these six children were positive for islet antibodies. Two were positive for all three antibodies, two were positive for ICA and GADA, and one was positive for GADA. Among the individual autoantibodies, ICA showed the... (More)
In 1987 serum was collected from 1031 non-diabetic schoolchildren in the Southeast area of Sweden with the aim of evaluating islet autoantibody status (ICA, GADA and IA2-ab) in the prediction of diabetes in schoolchildren. The clinical development of Type 1 diabetes in the children was assessed in 1994 and 1997. The combination of ICA, GADA and IA2-ab were found in four subjects whereas six had two and 35 children one of these antibodies. After 10 years, six of the 1031 children had developed clinical diabetes and five of these six children were positive for islet antibodies. Two were positive for all three antibodies, two were positive for ICA and GADA, and one was positive for GADA. Among the individual autoantibodies, ICA showed the highest positive predictive value (29%) whereas the predictive value for the combination of two autoantibodies was highest for GADA and ICA (40%). Thus, GADA and ICA measurements may be a rational approach to detect schoolchildren at risk for developing diabetes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Schoolchildren, Autoantibodies, Type 1 diabetes, Prediction
in
Diabetes Research and Clinical Practice
volume
51
issue
1
pages
51 - 57
publisher
Elsevier
external identifiers
  • wos:000166204700007
  • scopus:0035196395
ISSN
1872-8227
DOI
10.1016/S0168-8227(00)00199-6
language
English
LU publication?
yes
id
fdaf6827-bf30-4810-affa-48b71a24a047 (old id 1119721)
date added to LUP
2008-07-14 09:39:50
date last changed
2018-01-14 03:24:16
@article{fdaf6827-bf30-4810-affa-48b71a24a047,
  abstract     = {In 1987 serum was collected from 1031 non-diabetic schoolchildren in the Southeast area of Sweden with the aim of evaluating islet autoantibody status (ICA, GADA and IA2-ab) in the prediction of diabetes in schoolchildren. The clinical development of Type 1 diabetes in the children was assessed in 1994 and 1997. The combination of ICA, GADA and IA2-ab were found in four subjects whereas six had two and 35 children one of these antibodies. After 10 years, six of the 1031 children had developed clinical diabetes and five of these six children were positive for islet antibodies. Two were positive for all three antibodies, two were positive for ICA and GADA, and one was positive for GADA. Among the individual autoantibodies, ICA showed the highest positive predictive value (29%) whereas the predictive value for the combination of two autoantibodies was highest for GADA and ICA (40%). Thus, GADA and ICA measurements may be a rational approach to detect schoolchildren at risk for developing diabetes.},
  author       = {Samuelsson, U. and Sundkvist, Göran and Borg, Henrik and Fernlund, Per and Ludvigsson, J.},
  issn         = {1872-8227},
  keyword      = {Schoolchildren,Autoantibodies,Type 1 diabetes,Prediction},
  language     = {eng},
  number       = {1},
  pages        = {51--57},
  publisher    = {Elsevier},
  series       = {Diabetes Research and Clinical Practice},
  title        = {Islet autoantibodies in the prediction of diabetes in school children},
  url          = {http://dx.doi.org/10.1016/S0168-8227(00)00199-6},
  volume       = {51},
  year         = {2001},
}