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Preliminary study of D-dimer as a possible marker of acute bowel ischaemia

Acosta, Stefan LU ; Nilsson, T K and Bjorck, M (2001) In British Journal of Surgery 88(3). p.385-388
Abstract
BACKGROUND: Occlusion of the superior mesenteric artery (SMA) demands prompt recognition and diagnosis. No accurate diagnostic method is available. The aim of this study was to determine whether the fibrinolytic marker D-dimer is a useful early marker of acute bowel ischaemia. METHODS: Fourteen patients suspected of having acute bowel ischaemia were analysed for an increase in plasma D-dimer level. RESULTS: Six patients had embolic or thrombotic occlusion of the SMA and all had significantly higher D-dimer levels than those without thromboembolic occlusion (P < 0.05). Four patients with strangulation of the small bowel due to adhesions and one with a ruptured aortic aneurysm also had raised D-dimer values. CONCLUSION: In patients with... (More)
BACKGROUND: Occlusion of the superior mesenteric artery (SMA) demands prompt recognition and diagnosis. No accurate diagnostic method is available. The aim of this study was to determine whether the fibrinolytic marker D-dimer is a useful early marker of acute bowel ischaemia. METHODS: Fourteen patients suspected of having acute bowel ischaemia were analysed for an increase in plasma D-dimer level. RESULTS: Six patients had embolic or thrombotic occlusion of the SMA and all had significantly higher D-dimer levels than those without thromboembolic occlusion (P < 0.05). Four patients with strangulation of the small bowel due to adhesions and one with a ruptured aortic aneurysm also had raised D-dimer values. CONCLUSION: In patients with suspected thromboembolic occlusive disease of the SMA, a raised level of D-dimer indicated the presence of acute bowel ischaemia, whatever the cause. A more extensive prospective study is needed to evaluate a potential survival benefit using the test as a marker of the need for urgent laparotomy. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Surgery
volume
88
issue
3
pages
385 - 388
publisher
John Wiley & Sons
external identifiers
  • pmid:11260104
  • scopus:0035071918
ISSN
1365-2168
DOI
10.1046/j.1365-2168.2001.01711.x
language
English
LU publication?
no
id
38aa22a3-a352-4484-a34e-2d2f110db95f (old id 1119746)
date added to LUP
2008-06-23 12:57:02
date last changed
2018-01-07 05:49:54
@article{38aa22a3-a352-4484-a34e-2d2f110db95f,
  abstract     = {BACKGROUND: Occlusion of the superior mesenteric artery (SMA) demands prompt recognition and diagnosis. No accurate diagnostic method is available. The aim of this study was to determine whether the fibrinolytic marker D-dimer is a useful early marker of acute bowel ischaemia. METHODS: Fourteen patients suspected of having acute bowel ischaemia were analysed for an increase in plasma D-dimer level. RESULTS: Six patients had embolic or thrombotic occlusion of the SMA and all had significantly higher D-dimer levels than those without thromboembolic occlusion (P &lt; 0.05). Four patients with strangulation of the small bowel due to adhesions and one with a ruptured aortic aneurysm also had raised D-dimer values. CONCLUSION: In patients with suspected thromboembolic occlusive disease of the SMA, a raised level of D-dimer indicated the presence of acute bowel ischaemia, whatever the cause. A more extensive prospective study is needed to evaluate a potential survival benefit using the test as a marker of the need for urgent laparotomy.},
  author       = {Acosta, Stefan and Nilsson, T K and Bjorck, M},
  issn         = {1365-2168},
  language     = {eng},
  number       = {3},
  pages        = {385--388},
  publisher    = {John Wiley & Sons},
  series       = {British Journal of Surgery},
  title        = {Preliminary study of D-dimer as a possible marker of acute bowel ischaemia},
  url          = {http://dx.doi.org/10.1046/j.1365-2168.2001.01711.x},
  volume       = {88},
  year         = {2001},
}