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Semenogelin II gene is replaced by a truncated line 1 repeat in the cotton-top tamarin

Lundwall, Åke LU and Ceder, Yvonne LU (2001) In Biology of Reproduction 65(2). p.420-425
Abstract
The human seminal vesicles secrete two proteins, semenogelin I and semenogelin II, at very high concentrations. It has previously been shown that the cotton-top tamarin (Sanguinus oedipus), a New World monkey, is lacking the semenogelin II gene. We have now determined the nucleotide sequence of DNA located 5--13 kilobases (kb) downstream of the tamarin semenogelin I gene---a region that in man is occupied by the semenogelin II gene. Two regions with homology to the human semenogelin II gene were identified in the tamarin DNA. The first region, of 3.5 kb, is homologous to DNA upstream of the human gene, and the second region, of 0.6 kb, is mainly derived from the second intron. Between these regions, equivalent to 594 base pairs (bp)... (More)
The human seminal vesicles secrete two proteins, semenogelin I and semenogelin II, at very high concentrations. It has previously been shown that the cotton-top tamarin (Sanguinus oedipus), a New World monkey, is lacking the semenogelin II gene. We have now determined the nucleotide sequence of DNA located 5--13 kilobases (kb) downstream of the tamarin semenogelin I gene---a region that in man is occupied by the semenogelin II gene. Two regions with homology to the human semenogelin II gene were identified in the tamarin DNA. The first region, of 3.5 kb, is homologous to DNA upstream of the human gene, and the second region, of 0.6 kb, is mainly derived from the second intron. Between these regions, equivalent to 594 base pairs (bp) upstream of the transcription initiation site to 12 bp downstream of the stop codon in the human semenogelin II gene, the cotton-top tamarin DNA carries a truncated LINE1 repeat. In another set of experiments, the tamarin DNA hybridizing to the mouse semenoclotin gene was investigated. It was concluded that hybridization is with the second intron of the semenoclotin gene, but very likely, the material does not represent a cotton-top tamarin semenoclotin gene. Thus, a mammalian ancestor probably carried a single gene that in the rodent lineage developed into the semenoclotin gene and in the primate lineage into a progenitor of the semenogelin genes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gene regulation, male reproductive tract, seminal vesicles, sperm motility and transport
in
Biology of Reproduction
volume
65
issue
2
pages
420 - 425
publisher
Soc Study Reproduction
external identifiers
  • pmid:11466209
ISSN
1529-7268
language
English
LU publication?
yes
id
d47943dd-2e71-4488-af26-13ca836e3e26 (old id 1119868)
alternative location
http://www.biolreprod.org/cgi/content/full/65/2/420
date added to LUP
2008-07-04 12:24:42
date last changed
2016-04-15 18:39:39
@article{d47943dd-2e71-4488-af26-13ca836e3e26,
  abstract     = {The human seminal vesicles secrete two proteins, semenogelin I and semenogelin II, at very high concentrations. It has previously been shown that the cotton-top tamarin (Sanguinus oedipus), a New World monkey, is lacking the semenogelin II gene. We have now determined the nucleotide sequence of DNA located 5--13 kilobases (kb) downstream of the tamarin semenogelin I gene---a region that in man is occupied by the semenogelin II gene. Two regions with homology to the human semenogelin II gene were identified in the tamarin DNA. The first region, of 3.5 kb, is homologous to DNA upstream of the human gene, and the second region, of 0.6 kb, is mainly derived from the second intron. Between these regions, equivalent to 594 base pairs (bp) upstream of the transcription initiation site to 12 bp downstream of the stop codon in the human semenogelin II gene, the cotton-top tamarin DNA carries a truncated LINE1 repeat. In another set of experiments, the tamarin DNA hybridizing to the mouse semenoclotin gene was investigated. It was concluded that hybridization is with the second intron of the semenoclotin gene, but very likely, the material does not represent a cotton-top tamarin semenoclotin gene. Thus, a mammalian ancestor probably carried a single gene that in the rodent lineage developed into the semenoclotin gene and in the primate lineage into a progenitor of the semenogelin genes.},
  author       = {Lundwall, Åke and Ceder, Yvonne},
  issn         = {1529-7268},
  keyword      = {gene regulation,male reproductive tract,seminal vesicles,sperm motility and transport},
  language     = {eng},
  number       = {2},
  pages        = {420--425},
  publisher    = {Soc Study Reproduction},
  series       = {Biology of Reproduction},
  title        = {Semenogelin II gene is replaced by a truncated line 1 repeat in the cotton-top tamarin},
  volume       = {65},
  year         = {2001},
}