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Regulation of human neutrophil granule protein expression

Borregaard, N; Theilgaard-Monch, K; Sørensen, Ole E LU and Cowland, J B (2001) In Current Opinion in Hematology 8(1). p.23-27
Abstract
The function of the mature polymorphonuclear neutrophil is dependent on its granules, each with its characteristic content of proteins. The granule proteins are formed at different stages during maturation of neutrophils from myeloblasts to segmented cells. The regulation of granule protein expression is controlled by a number of transcription factors, many of which are also essential for commitment of multipotent hematopoietic stem cells to lineage-committed myeloid progenitor cells and for differentiation of these progenitor cells; among these, PU.1 and C/EBPalpha stand out as critical for all granule proteins whereas AML-1 is critical for primary granule protein expression and C/EBPepsilon for secondary and tertiary granule protein... (More)
The function of the mature polymorphonuclear neutrophil is dependent on its granules, each with its characteristic content of proteins. The granule proteins are formed at different stages during maturation of neutrophils from myeloblasts to segmented cells. The regulation of granule protein expression is controlled by a number of transcription factors, many of which are also essential for commitment of multipotent hematopoietic stem cells to lineage-committed myeloid progenitor cells and for differentiation of these progenitor cells; among these, PU.1 and C/EBPalpha stand out as critical for all granule proteins whereas AML-1 is critical for primary granule protein expression and C/EBPepsilon for secondary and tertiary granule protein expression. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Hematology
volume
8
issue
1
pages
23 - 27
publisher
Lippincott Williams and Wilkins Ltd.
external identifiers
  • pmid:11138622
  • scopus:0035171827
ISSN
1531-7048
language
English
LU publication?
yes
id
4ac7864c-bcb8-486e-a345-8a2444bffd7a (old id 1119957)
date added to LUP
2008-06-25 13:07:02
date last changed
2018-05-29 09:27:23
@article{4ac7864c-bcb8-486e-a345-8a2444bffd7a,
  abstract     = {The function of the mature polymorphonuclear neutrophil is dependent on its granules, each with its characteristic content of proteins. The granule proteins are formed at different stages during maturation of neutrophils from myeloblasts to segmented cells. The regulation of granule protein expression is controlled by a number of transcription factors, many of which are also essential for commitment of multipotent hematopoietic stem cells to lineage-committed myeloid progenitor cells and for differentiation of these progenitor cells; among these, PU.1 and C/EBPalpha stand out as critical for all granule proteins whereas AML-1 is critical for primary granule protein expression and C/EBPepsilon for secondary and tertiary granule protein expression.},
  author       = {Borregaard, N and Theilgaard-Monch, K and Sørensen, Ole E and Cowland, J B},
  issn         = {1531-7048},
  language     = {eng},
  number       = {1},
  pages        = {23--27},
  publisher    = {Lippincott Williams and Wilkins Ltd.},
  series       = {Current Opinion in Hematology},
  title        = {Regulation of human neutrophil granule protein expression},
  volume       = {8},
  year         = {2001},
}