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Novel quantitative trait Loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations.

Karlsson, Jenny C LU ; Zhao, Xiangshan LU ; Lonskaya, Irina LU ; Neptin, Malin LU ; Holmdahl, Rikard LU and Andersson, Åsa LU (2003) In Journal of Immunology 170(2). p.1019-1026
Abstract
The B10.RIII mouse strain (H-2r) develops chronic experimental autoimmune encephalomyelitis (EAE) upon immunization with the myelin basic protein 89–101 peptide. EAE was induced and studied in a backcross between B10.RIII and the EAE-resistant RIIIS/J strain (H-2r), and a complete genome scan with microsatellite markers was performed. Five loci were significantly linked to different traits and clinical subtypes of EAE on chromosomes 1, 5, 11, 15, and 16, three of the loci having sex specificity. The quantitative trait locus on chromosome 15 partly overlapped with the Eae2 locus, previously identified in crosses between the B10.RIII and RIIIS/J mouse strains. The loci on chromosomes 11 and 16 overlapped with Eae loci identified in other... (More)
The B10.RIII mouse strain (H-2r) develops chronic experimental autoimmune encephalomyelitis (EAE) upon immunization with the myelin basic protein 89–101 peptide. EAE was induced and studied in a backcross between B10.RIII and the EAE-resistant RIIIS/J strain (H-2r), and a complete genome scan with microsatellite markers was performed. Five loci were significantly linked to different traits and clinical subtypes of EAE on chromosomes 1, 5, 11, 15, and 16, three of the loci having sex specificity. The quantitative trait locus on chromosome 15 partly overlapped with the Eae2 locus, previously identified in crosses between the B10.RIII and RIIIS/J mouse strains. The loci on chromosomes 11 and 16 overlapped with Eae loci identified in other mouse crosses. By analyzing the backcross animals for lymphocyte phenotypes, the proportion of B and T cells in addition to the levels of CD4+CD8- and CD4-CD8+ T cells and the CD4+/CD8+ ratio in spleen were linked to different loci on chromosomes 1, 2, 3, 5, 6, 11, and 15. On chromosome 16, we found significant linkage to spleen cell proliferation. Several linkages overlapped with the quantitative trait loci for disease phenotypes. The identification of subphenotypes that are linked to the same loci as disease traits could be most useful in the search for candidate genes and biological pathways involved in the pathological process. (Less)
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organization
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Contribution to journal
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published
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in
Journal of Immunology
volume
170
issue
2
pages
1019 - 1026
publisher
American Association of Immunologists
external identifiers
  • pmid:12517969
  • wos:000180294300044
  • scopus:0037438369
ISSN
1550-6606
language
English
LU publication?
yes
id
04e8f4d9-d250-4915-9954-12d9b53b6a90 (old id 112013)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12517969&dopt=Abstract
date added to LUP
2007-07-16 11:37:04
date last changed
2018-01-07 09:21:01
@article{04e8f4d9-d250-4915-9954-12d9b53b6a90,
  abstract     = {The B10.RIII mouse strain (H-2r) develops chronic experimental autoimmune encephalomyelitis (EAE) upon immunization with the myelin basic protein 89–101 peptide. EAE was induced and studied in a backcross between B10.RIII and the EAE-resistant RIIIS/J strain (H-2r), and a complete genome scan with microsatellite markers was performed. Five loci were significantly linked to different traits and clinical subtypes of EAE on chromosomes 1, 5, 11, 15, and 16, three of the loci having sex specificity. The quantitative trait locus on chromosome 15 partly overlapped with the Eae2 locus, previously identified in crosses between the B10.RIII and RIIIS/J mouse strains. The loci on chromosomes 11 and 16 overlapped with Eae loci identified in other mouse crosses. By analyzing the backcross animals for lymphocyte phenotypes, the proportion of B and T cells in addition to the levels of CD4+CD8- and CD4-CD8+ T cells and the CD4+/CD8+ ratio in spleen were linked to different loci on chromosomes 1, 2, 3, 5, 6, 11, and 15. On chromosome 16, we found significant linkage to spleen cell proliferation. Several linkages overlapped with the quantitative trait loci for disease phenotypes. The identification of subphenotypes that are linked to the same loci as disease traits could be most useful in the search for candidate genes and biological pathways involved in the pathological process.},
  author       = {Karlsson, Jenny C and Zhao, Xiangshan and Lonskaya, Irina and Neptin, Malin and Holmdahl, Rikard and Andersson, Åsa},
  issn         = {1550-6606},
  language     = {eng},
  number       = {2},
  pages        = {1019--1026},
  publisher    = {American Association of Immunologists},
  series       = {Journal of Immunology},
  title        = {Novel quantitative trait Loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations.},
  volume       = {170},
  year         = {2003},
}