Advanced

Breast cancer incidence in ex-smokers in relation to body mass index, weight gain and blood lipid levels

Manjer, Jonas LU ; Malina, J; Berglund, Göran LU ; Bondeson, Lennart LU ; Garne, J P and Janzon, Lars LU (2001) In European Journal of Cancer Prevention 10(3). p.281-287
Abstract
According to several studies breast cancer is more common among former smokers. This study explores whether this association has any relationship with anthropometric measurements or blood lipid levels. The 2082 ex-smokers (mean age 49.9 years) in the Malmo Preventive Cohort were followed for an average of 13.3 years using official cancer registries. This yielded 93 incident breast cancer cases. Oestrogen receptor (ER) status was assessed by an immunological method. Incidence of breast cancer covaried with height, body mass index, weight gain and cholesterol levels. None of these associations reached statistical significance. Incidence of breast cancer increased over quartiles of serum triglycerides, Ptrend: 0.02, relative risk (RR) for... (More)
According to several studies breast cancer is more common among former smokers. This study explores whether this association has any relationship with anthropometric measurements or blood lipid levels. The 2082 ex-smokers (mean age 49.9 years) in the Malmo Preventive Cohort were followed for an average of 13.3 years using official cancer registries. This yielded 93 incident breast cancer cases. Oestrogen receptor (ER) status was assessed by an immunological method. Incidence of breast cancer covaried with height, body mass index, weight gain and cholesterol levels. None of these associations reached statistical significance. Incidence of breast cancer increased over quartiles of serum triglycerides, Ptrend: 0.02, relative risk (RR) for triglycerides as a continuous variable: 1.46 (1.21-1.77). Nineteen tumours were ER negative; this subgroup was similarly related to high triglycerides, 1.76 (1.40-2.21). All results were similar when BMI and cholesterol levels were entered into the model. It is concluded that breast cancer incidence covaries with triglyceride levels in ex-smokers. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breast cancer, hormone receptor status, smoking cessation, triglycerides
in
European Journal of Cancer Prevention
volume
10
issue
3
pages
281 - 287
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:11432717
  • scopus:0034982425
ISSN
1473-5709
language
English
LU publication?
yes
id
221f17a2-e34d-41f5-a3e4-2533abeed493 (old id 1120190)
date added to LUP
2008-07-04 14:00:12
date last changed
2018-01-07 05:43:01
@article{221f17a2-e34d-41f5-a3e4-2533abeed493,
  abstract     = {According to several studies breast cancer is more common among former smokers. This study explores whether this association has any relationship with anthropometric measurements or blood lipid levels. The 2082 ex-smokers (mean age 49.9 years) in the Malmo Preventive Cohort were followed for an average of 13.3 years using official cancer registries. This yielded 93 incident breast cancer cases. Oestrogen receptor (ER) status was assessed by an immunological method. Incidence of breast cancer covaried with height, body mass index, weight gain and cholesterol levels. None of these associations reached statistical significance. Incidence of breast cancer increased over quartiles of serum triglycerides, Ptrend: 0.02, relative risk (RR) for triglycerides as a continuous variable: 1.46 (1.21-1.77). Nineteen tumours were ER negative; this subgroup was similarly related to high triglycerides, 1.76 (1.40-2.21). All results were similar when BMI and cholesterol levels were entered into the model. It is concluded that breast cancer incidence covaries with triglyceride levels in ex-smokers.},
  author       = {Manjer, Jonas and Malina, J and Berglund, Göran and Bondeson, Lennart and Garne, J P and Janzon, Lars},
  issn         = {1473-5709},
  keyword      = {Breast cancer,hormone receptor status,smoking cessation,triglycerides},
  language     = {eng},
  number       = {3},
  pages        = {281--287},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Cancer Prevention},
  title        = {Breast cancer incidence in ex-smokers in relation to body mass index, weight gain and blood lipid levels},
  volume       = {10},
  year         = {2001},
}