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Low-flow anaesthesia with desflurane: kinetics during clinical procedures

Johansson, Anders LU ; Lundberg, Dag LU and Luttropp, Hans-Henrik LU (2001) In European Journal of Anaesthesiology 18(8). p.499-504
Abstract
BACKGROUND AND OBJECTIVE: Low-flow anaesthesia is economical and less polluting. The purpose of this study was to determine the inspired and end-tidal desflurane concentrations during anaesthesia with a vaporizer setting maintained at 5%, during low-flow anaesthesia after 120 min with fresh gas inflows of 1.0 and 2.0 L min-1. METHODS: The study was both prospective and randomized, including 56 patients (28 patients in each group) scheduled for elective surgery of an expected anaesthesia time of at least 120 min. Inspired and end-tidal concentrations of desflurane were measured during low-flow anaesthesia with fresh gas inflows of 1.0 and 2.0 L min-1. The vaporizer setting was fixed at 5% desflurane. RESULTS: The inspired and end-tidal... (More)
BACKGROUND AND OBJECTIVE: Low-flow anaesthesia is economical and less polluting. The purpose of this study was to determine the inspired and end-tidal desflurane concentrations during anaesthesia with a vaporizer setting maintained at 5%, during low-flow anaesthesia after 120 min with fresh gas inflows of 1.0 and 2.0 L min-1. METHODS: The study was both prospective and randomized, including 56 patients (28 patients in each group) scheduled for elective surgery of an expected anaesthesia time of at least 120 min. Inspired and end-tidal concentrations of desflurane were measured during low-flow anaesthesia with fresh gas inflows of 1.0 and 2.0 L min-1. The vaporizer setting was fixed at 5% desflurane. RESULTS: The inspired and end-tidal concentrations of desflurane in the 1.0 L min-1 group after 120 min were 4.54% vs. 4.37% (P < 0.001). In the 2.0 L min-1 group, the inspired and end-tidal concentrations of desflurane were 4.76% vs. 4.58% (P < 0.001). The estimated end-tidal/inspired ratios at 120 min of anaesthesia were 0.96 in both groups. At a fresh gas flow of 1.0 L min-1, the end-tidal concentration was 0.87 of the vaporizer setting. Increasing the fresh gas flow to 2.0 L min-1 increased the end-tidal value by 0.05. CONCLUSION: There is a significant difference between the inspired and end-tidal concentrations of desflurane when fresh gas inflows were 1.0 and 2.0 L min-1, but not for the ratio of inspired/end-tidal. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Anaesthesiology
volume
18
issue
8
pages
499 - 504
publisher
European Society of Anaesthesiology
external identifiers
  • pmid:11473555
  • scopus:0034834198
ISSN
1365-2346
DOI
10.1046/j.1365-2346.2001.00872.x
language
English
LU publication?
yes
id
dfd6250d-8b64-4de4-affe-7ba9d90b76a9 (old id 1120223)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/11473555
date added to LUP
2008-06-23 11:43:38
date last changed
2018-05-29 12:20:26
@article{dfd6250d-8b64-4de4-affe-7ba9d90b76a9,
  abstract     = {BACKGROUND AND OBJECTIVE: Low-flow anaesthesia is economical and less polluting. The purpose of this study was to determine the inspired and end-tidal desflurane concentrations during anaesthesia with a vaporizer setting maintained at 5%, during low-flow anaesthesia after 120 min with fresh gas inflows of 1.0 and 2.0 L min-1. METHODS: The study was both prospective and randomized, including 56 patients (28 patients in each group) scheduled for elective surgery of an expected anaesthesia time of at least 120 min. Inspired and end-tidal concentrations of desflurane were measured during low-flow anaesthesia with fresh gas inflows of 1.0 and 2.0 L min-1. The vaporizer setting was fixed at 5% desflurane. RESULTS: The inspired and end-tidal concentrations of desflurane in the 1.0 L min-1 group after 120 min were 4.54% vs. 4.37% (P &lt; 0.001). In the 2.0 L min-1 group, the inspired and end-tidal concentrations of desflurane were 4.76% vs. 4.58% (P &lt; 0.001). The estimated end-tidal/inspired ratios at 120 min of anaesthesia were 0.96 in both groups. At a fresh gas flow of 1.0 L min-1, the end-tidal concentration was 0.87 of the vaporizer setting. Increasing the fresh gas flow to 2.0 L min-1 increased the end-tidal value by 0.05. CONCLUSION: There is a significant difference between the inspired and end-tidal concentrations of desflurane when fresh gas inflows were 1.0 and 2.0 L min-1, but not for the ratio of inspired/end-tidal.},
  author       = {Johansson, Anders and Lundberg, Dag and Luttropp, Hans-Henrik},
  issn         = {1365-2346},
  language     = {eng},
  number       = {8},
  pages        = {499--504},
  publisher    = {European Society of Anaesthesiology},
  series       = {European Journal of Anaesthesiology},
  title        = {Low-flow anaesthesia with desflurane: kinetics during clinical procedures},
  url          = {http://dx.doi.org/10.1046/j.1365-2346.2001.00872.x},
  volume       = {18},
  year         = {2001},
}