Extensive cytogenetic heterogeneity in a benign retroperitoneal schwannoma
(2001) In Cancer Genetics and Cytogenetics 127(2). p.148-154- Abstract
- A benign retroperitoneal schwannoma from a patient without prior exposure to radiotherapy or chemotherapy was analyzed by chromosome banding after short-term culture. An extensive intratumor heterogeneity in the form of 29 karyotypically related as well as unrelated clones was found. The aberrant clones were diploid or near-diploid and displayed both numerical and structural changes. All chromosomes, except 11, 16, and 20, were affected. Numerical changes included trisomies X, 7, 9, 17, and 18, and monosomies 13 and 18. No clonal loss of chromosome 22, the most characteristic abnormality in schwannomas of other locations, was, however, detected. The structural aberrations resulted in a total of 58 chromosomal breakpoints, with chromosomes... (More)
- A benign retroperitoneal schwannoma from a patient without prior exposure to radiotherapy or chemotherapy was analyzed by chromosome banding after short-term culture. An extensive intratumor heterogeneity in the form of 29 karyotypically related as well as unrelated clones was found. The aberrant clones were diploid or near-diploid and displayed both numerical and structural changes. All chromosomes, except 11, 16, and 20, were affected. Numerical changes included trisomies X, 7, 9, 17, and 18, and monosomies 13 and 18. No clonal loss of chromosome 22, the most characteristic abnormality in schwannomas of other locations, was, however, detected. The structural aberrations resulted in a total of 58 chromosomal breakpoints, with chromosomes 18, 1, and 15 participating in rearrangements most frequently, followed by chromosomes 14, 2, and 22. A striking finding was the clonal involvement of 18p11 in eight rearrangements affecting different chromosomes, suggesting alteration of telomeric function. The molecular mechanisms underlying the observed massive polyclonality in the schwannoma, particularly the presence of cytogenetically unrelated clones, are unknown and probably heterogeneous. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1120429
- author
- Gorunova, Ludmila LU ; Dawiskiba, Sigmund LU ; Andren-Sandberg, Åke ; Höglund, Mattias LU and Johansson, Bertil LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Genetics and Cytogenetics
- volume
- 127
- issue
- 2
- pages
- 148 - 154
- publisher
- Elsevier
- external identifiers
-
- pmid:11425455
- scopus:0034968408
- ISSN
- 0165-4608
- DOI
- 10.1016/S0165-4608(00)00440-4
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Clinical Genetics (013022003), Pathology, (Lund) (013030000)
- id
- caadd2c7-701f-4e6b-8332-1add1be24604 (old id 1120429)
- date added to LUP
- 2016-04-01 16:32:23
- date last changed
- 2022-01-28 20:23:14
@article{caadd2c7-701f-4e6b-8332-1add1be24604,
abstract = {{A benign retroperitoneal schwannoma from a patient without prior exposure to radiotherapy or chemotherapy was analyzed by chromosome banding after short-term culture. An extensive intratumor heterogeneity in the form of 29 karyotypically related as well as unrelated clones was found. The aberrant clones were diploid or near-diploid and displayed both numerical and structural changes. All chromosomes, except 11, 16, and 20, were affected. Numerical changes included trisomies X, 7, 9, 17, and 18, and monosomies 13 and 18. No clonal loss of chromosome 22, the most characteristic abnormality in schwannomas of other locations, was, however, detected. The structural aberrations resulted in a total of 58 chromosomal breakpoints, with chromosomes 18, 1, and 15 participating in rearrangements most frequently, followed by chromosomes 14, 2, and 22. A striking finding was the clonal involvement of 18p11 in eight rearrangements affecting different chromosomes, suggesting alteration of telomeric function. The molecular mechanisms underlying the observed massive polyclonality in the schwannoma, particularly the presence of cytogenetically unrelated clones, are unknown and probably heterogeneous.}},
author = {{Gorunova, Ludmila and Dawiskiba, Sigmund and Andren-Sandberg, Åke and Höglund, Mattias and Johansson, Bertil}},
issn = {{0165-4608}},
language = {{eng}},
number = {{2}},
pages = {{148--154}},
publisher = {{Elsevier}},
series = {{Cancer Genetics and Cytogenetics}},
title = {{Extensive cytogenetic heterogeneity in a benign retroperitoneal schwannoma}},
url = {{http://dx.doi.org/10.1016/S0165-4608(00)00440-4}},
doi = {{10.1016/S0165-4608(00)00440-4}},
volume = {{127}},
year = {{2001}},
}