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Extensive cytogenetic heterogeneity in a benign retroperitoneal schwannoma

Gorunova, Ludmila LU ; Dawiskiba, Sigmund LU ; Andren-Sandberg, Åke; Höglund, Mattias LU and Johansson, Bertil LU (2001) In Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00 127(2). p.148-154
Abstract
A benign retroperitoneal schwannoma from a patient without prior exposure to radiotherapy or chemotherapy was analyzed by chromosome banding after short-term culture. An extensive intratumor heterogeneity in the form of 29 karyotypically related as well as unrelated clones was found. The aberrant clones were diploid or near-diploid and displayed both numerical and structural changes. All chromosomes, except 11, 16, and 20, were affected. Numerical changes included trisomies X, 7, 9, 17, and 18, and monosomies 13 and 18. No clonal loss of chromosome 22, the most characteristic abnormality in schwannomas of other locations, was, however, detected. The structural aberrations resulted in a total of 58 chromosomal breakpoints, with chromosomes... (More)
A benign retroperitoneal schwannoma from a patient without prior exposure to radiotherapy or chemotherapy was analyzed by chromosome banding after short-term culture. An extensive intratumor heterogeneity in the form of 29 karyotypically related as well as unrelated clones was found. The aberrant clones were diploid or near-diploid and displayed both numerical and structural changes. All chromosomes, except 11, 16, and 20, were affected. Numerical changes included trisomies X, 7, 9, 17, and 18, and monosomies 13 and 18. No clonal loss of chromosome 22, the most characteristic abnormality in schwannomas of other locations, was, however, detected. The structural aberrations resulted in a total of 58 chromosomal breakpoints, with chromosomes 18, 1, and 15 participating in rearrangements most frequently, followed by chromosomes 14, 2, and 22. A striking finding was the clonal involvement of 18p11 in eight rearrangements affecting different chromosomes, suggesting alteration of telomeric function. The molecular mechanisms underlying the observed massive polyclonality in the schwannoma, particularly the presence of cytogenetically unrelated clones, are unknown and probably heterogeneous. (Less)
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Contribution to journal
publication status
published
subject
in
Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00
volume
127
issue
2
pages
148 - 154
publisher
Elsevier
external identifiers
  • pmid:11425455
  • scopus:0034968408
ISSN
0165-4608
DOI
10.1016/S0165-4608(00)00440-4
language
English
LU publication?
yes
id
caadd2c7-701f-4e6b-8332-1add1be24604 (old id 1120429)
date added to LUP
2008-06-27 15:33:12
date last changed
2018-01-07 09:21:18
@article{caadd2c7-701f-4e6b-8332-1add1be24604,
  abstract     = {A benign retroperitoneal schwannoma from a patient without prior exposure to radiotherapy or chemotherapy was analyzed by chromosome banding after short-term culture. An extensive intratumor heterogeneity in the form of 29 karyotypically related as well as unrelated clones was found. The aberrant clones were diploid or near-diploid and displayed both numerical and structural changes. All chromosomes, except 11, 16, and 20, were affected. Numerical changes included trisomies X, 7, 9, 17, and 18, and monosomies 13 and 18. No clonal loss of chromosome 22, the most characteristic abnormality in schwannomas of other locations, was, however, detected. The structural aberrations resulted in a total of 58 chromosomal breakpoints, with chromosomes 18, 1, and 15 participating in rearrangements most frequently, followed by chromosomes 14, 2, and 22. A striking finding was the clonal involvement of 18p11 in eight rearrangements affecting different chromosomes, suggesting alteration of telomeric function. The molecular mechanisms underlying the observed massive polyclonality in the schwannoma, particularly the presence of cytogenetically unrelated clones, are unknown and probably heterogeneous.},
  author       = {Gorunova, Ludmila and Dawiskiba, Sigmund and Andren-Sandberg, Åke and Höglund, Mattias and Johansson, Bertil},
  issn         = {0165-4608},
  language     = {eng},
  number       = {2},
  pages        = {148--154},
  publisher    = {Elsevier},
  series       = {Cancer Genetics and Cytogenetics1979-01-01+01:002011-01-01+01:00},
  title        = {Extensive cytogenetic heterogeneity in a benign retroperitoneal schwannoma},
  url          = {http://dx.doi.org/10.1016/S0165-4608(00)00440-4},
  volume       = {127},
  year         = {2001},
}