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Histopathological and cell biological factors of ductal carcinoma in situ before and after the introduction of mammographic screening

Idvall, Ingrid LU ; Andersson, Christina; Fallenius, Ghita; Ingvar, Christian LU ; Ringberg, Anita LU ; Forsare, Carina LU ; Åkerman, Måns LU and Fernö, Mårten LU (2001) In Acta Oncologica 40(5). p.653-659
Abstract
With the introduction of mammographic screening the incidence of ductal carcinoma in situ (DCIS) has increased to 10-15% of all breast cancers. The aim of this study was to investigate whether there were any morphological and cell biological differences between DCIS detected during the pre-screening (n = 39) as opposed to the screening period (n = 120). We could not demonstrate any statistically significant differences between the pre-screening and the screening period with regard to nuclear grade, presence of necrosis, the Van Nuys classification system, growth pattern, or cell biological factors (estrogen and progesterone receptors, c-erbB-2, p53, DNA ploidy status, Ki67, and Auer classes). These findings suggest that DCIS tumors... (More)
With the introduction of mammographic screening the incidence of ductal carcinoma in situ (DCIS) has increased to 10-15% of all breast cancers. The aim of this study was to investigate whether there were any morphological and cell biological differences between DCIS detected during the pre-screening (n = 39) as opposed to the screening period (n = 120). We could not demonstrate any statistically significant differences between the pre-screening and the screening period with regard to nuclear grade, presence of necrosis, the Van Nuys classification system, growth pattern, or cell biological factors (estrogen and progesterone receptors, c-erbB-2, p53, DNA ploidy status, Ki67, and Auer classes). These findings suggest that DCIS tumors detected during the two time periods have a similar malignant potential. DCIS detected during the screening period was further divided into the prevalence period versus the period thereafter, and symptomatic versus screening-detected asymptomatic cases. More cases with diffuse growth patterns were seen during the prevalence period than after the prevalence period, and screening-detected asymptomatic DCISs were more often 15 mm or smaller in diameter than DCISs detected symptomatically. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
40
issue
5
pages
653 - 659
publisher
Taylor & Francis
external identifiers
  • pmid:11669340
  • scopus:0034794724
ISSN
1651-226X
DOI
10.1080/028418601750444222
language
English
LU publication?
yes
id
0b85da27-673d-44d4-8f97-1f36d4a34dc7 (old id 1120741)
date added to LUP
2008-06-30 15:54:46
date last changed
2018-01-07 09:11:45
@article{0b85da27-673d-44d4-8f97-1f36d4a34dc7,
  abstract     = {With the introduction of mammographic screening the incidence of ductal carcinoma in situ (DCIS) has increased to 10-15% of all breast cancers. The aim of this study was to investigate whether there were any morphological and cell biological differences between DCIS detected during the pre-screening (n = 39) as opposed to the screening period (n = 120). We could not demonstrate any statistically significant differences between the pre-screening and the screening period with regard to nuclear grade, presence of necrosis, the Van Nuys classification system, growth pattern, or cell biological factors (estrogen and progesterone receptors, c-erbB-2, p53, DNA ploidy status, Ki67, and Auer classes). These findings suggest that DCIS tumors detected during the two time periods have a similar malignant potential. DCIS detected during the screening period was further divided into the prevalence period versus the period thereafter, and symptomatic versus screening-detected asymptomatic cases. More cases with diffuse growth patterns were seen during the prevalence period than after the prevalence period, and screening-detected asymptomatic DCISs were more often 15 mm or smaller in diameter than DCISs detected symptomatically.},
  author       = {Idvall, Ingrid and Andersson, Christina and Fallenius, Ghita and Ingvar, Christian and Ringberg, Anita and Forsare, Carina and Åkerman, Måns and Fernö, Mårten},
  issn         = {1651-226X},
  language     = {eng},
  number       = {5},
  pages        = {653--659},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Histopathological and cell biological factors of ductal carcinoma in situ before and after the introduction of mammographic screening},
  url          = {http://dx.doi.org/10.1080/028418601750444222},
  volume       = {40},
  year         = {2001},
}