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Rat tooth pulp cells elicit neurite growth from trigeminal neurones and express mRNAs for neurotrophic factors in vitro

Lillesaar, C; Eriksson Linsmeier, Cecilia LU and Fried, K (2001) In Neuroscience Letters 308(3). p.161-164
Abstract
Molecular factors control the developmental ingrowth of axons to the tooth pulp. Here we examine the ability of pulpal cells to induce neurite outgrowth from neonatal rat trigeminal neurones (TGNs) in vitro. We found that TGNs emitted neurites and formed networks of branches in relation to pulpal cells. Neurones co-cultured with a mixture of pulpal cells and 3T3 fibroblasts formed networks exclusively in relation to the pulpal cells. Cultivated pulpal cells and pulpal tissue produced mRNAs for all neurotrophins and members of the glial cell line-derived neurotrophic factor family. Hence, rat pulpal cells have neuritogenic effects on single TGNs in vitro, that may be associated with secretion of neurotrophic factors.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Trigeminal ganglion, Dental pulp, Rat, Cell culture, Neurotrophic factors, Neuritogenesis
in
Neuroscience Letters
volume
308
issue
3
pages
161 - 164
publisher
Elsevier
external identifiers
  • pmid:11479013
  • scopus:0035839260
ISSN
0304-3940
DOI
10.1016/S0304-3940(01)01997-8
language
English
LU publication?
yes
id
90c01b57-61e7-46b6-adbb-87b41535def1 (old id 1120793)
alternative location
http://www.sciencedirect.com/science/article/pii/S0304394001019978
http://www.ncbi.nlm.nih.gov/pubmed/11479013
date added to LUP
2008-08-27 13:32:47
date last changed
2018-05-29 10:20:20
@article{90c01b57-61e7-46b6-adbb-87b41535def1,
  abstract     = {Molecular factors control the developmental ingrowth of axons to the tooth pulp. Here we examine the ability of pulpal cells to induce neurite outgrowth from neonatal rat trigeminal neurones (TGNs) in vitro. We found that TGNs emitted neurites and formed networks of branches in relation to pulpal cells. Neurones co-cultured with a mixture of pulpal cells and 3T3 fibroblasts formed networks exclusively in relation to the pulpal cells. Cultivated pulpal cells and pulpal tissue produced mRNAs for all neurotrophins and members of the glial cell line-derived neurotrophic factor family. Hence, rat pulpal cells have neuritogenic effects on single TGNs in vitro, that may be associated with secretion of neurotrophic factors.},
  author       = {Lillesaar, C and Eriksson Linsmeier, Cecilia and Fried, K},
  issn         = {0304-3940},
  keyword      = {Trigeminal ganglion,Dental pulp,Rat,Cell culture,Neurotrophic factors,Neuritogenesis},
  language     = {eng},
  number       = {3},
  pages        = {161--164},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Rat tooth pulp cells elicit neurite growth from trigeminal neurones and express mRNAs for neurotrophic factors in vitro},
  url          = {http://dx.doi.org/10.1016/S0304-3940(01)01997-8},
  volume       = {308},
  year         = {2001},
}