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The BRCA1 syndrome and other inherited breast or breast-ovarian cancers in a Norwegian prospective series

Möller, P; Borg, Åke LU ; Heimdal, K; Apold, J; Vallon-Christersson, Johan LU ; Hovig, E and Maehle, L (2001) In European Journal of Cancer 37(8). p.1027-1032
Abstract
Inherited breast cancer is a heterogenous group of diseases. We examined this heterogeneity in a prospective series of inherited breast and ovarian cancers, previously demonstrated to include 84% of inherited cancers. Ninety-two tumours (65 breast and 27 ovarian) in 82 patients from 70 kindreds were prospectively diagnosed. Fifteen of the breast cancers were in situ, 50 were infiltrating. 40 (49%) of the 82 women carried a BRCA1 mutation, whereas no mutation in BRCA2 was found. Approximately, two-thirds of the BRCA1 mutation carriers had one of the four most frequent Norwegian founder mutations. Ninety-five per cent of the epithelial ovarian cancers occurred in BRCA1 mutation carrying women versus 38% of infiltrating breast cancers and 7%... (More)
Inherited breast cancer is a heterogenous group of diseases. We examined this heterogeneity in a prospective series of inherited breast and ovarian cancers, previously demonstrated to include 84% of inherited cancers. Ninety-two tumours (65 breast and 27 ovarian) in 82 patients from 70 kindreds were prospectively diagnosed. Fifteen of the breast cancers were in situ, 50 were infiltrating. 40 (49%) of the 82 women carried a BRCA1 mutation, whereas no mutation in BRCA2 was found. Approximately, two-thirds of the BRCA1 mutation carriers had one of the four most frequent Norwegian founder mutations. Ninety-five per cent of the epithelial ovarian cancers occurred in BRCA1 mutation carrying women versus 38% of infiltrating breast cancers and 7% of carcinoma in situ of the breast. The BRCA1 syndrome was phenotypically distinct with invasive, high grade, oestrogen receptor-negative breast cancers and epithelial ovarian cancers. Non-BRCA1/2 inherited breast cancers included carcinoma in situ and lobular carcinoma and were frequently bilateral. Non-BRCA1/2 inherited breast cancer is not associated with epithelial ovarian cancer and in breast cancers has distinct biological characteristics, indicating that the different subgroups of inherited breast cancer may need different healthcare services. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
BRCA1, BRCA2, Inherited, Breast cancer, Ovarian cancer, Oestrogen receptor, Epidemiology
in
European Journal of Cancer
volume
37
issue
8
pages
1027 - 1032
publisher
IFAC & Elsevier Ltd.
external identifiers
  • pmid:11334729
  • wos:000168798900021
  • scopus:0035040839
ISSN
1879-0852
DOI
10.1016/S0959-8049(01)00075-2
language
English
LU publication?
yes
id
f0be9661-a0c3-42b7-a3b3-1e04e495620b (old id 1120797)
date added to LUP
2008-07-08 08:56:08
date last changed
2018-05-29 11:33:29
@article{f0be9661-a0c3-42b7-a3b3-1e04e495620b,
  abstract     = {Inherited breast cancer is a heterogenous group of diseases. We examined this heterogeneity in a prospective series of inherited breast and ovarian cancers, previously demonstrated to include 84% of inherited cancers. Ninety-two tumours (65 breast and 27 ovarian) in 82 patients from 70 kindreds were prospectively diagnosed. Fifteen of the breast cancers were in situ, 50 were infiltrating. 40 (49%) of the 82 women carried a BRCA1 mutation, whereas no mutation in BRCA2 was found. Approximately, two-thirds of the BRCA1 mutation carriers had one of the four most frequent Norwegian founder mutations. Ninety-five per cent of the epithelial ovarian cancers occurred in BRCA1 mutation carrying women versus 38% of infiltrating breast cancers and 7% of carcinoma in situ of the breast. The BRCA1 syndrome was phenotypically distinct with invasive, high grade, oestrogen receptor-negative breast cancers and epithelial ovarian cancers. Non-BRCA1/2 inherited breast cancers included carcinoma in situ and lobular carcinoma and were frequently bilateral. Non-BRCA1/2 inherited breast cancer is not associated with epithelial ovarian cancer and in breast cancers has distinct biological characteristics, indicating that the different subgroups of inherited breast cancer may need different healthcare services.},
  author       = {Möller, P and Borg, Åke and Heimdal, K and Apold, J and Vallon-Christersson, Johan and Hovig, E and Maehle, L},
  issn         = {1879-0852},
  keyword      = {BRCA1,BRCA2,Inherited,Breast cancer,Ovarian cancer,Oestrogen receptor,Epidemiology},
  language     = {eng},
  number       = {8},
  pages        = {1027--1032},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {The BRCA1 syndrome and other inherited breast or breast-ovarian cancers in a Norwegian prospective series},
  url          = {http://dx.doi.org/10.1016/S0959-8049(01)00075-2},
  volume       = {37},
  year         = {2001},
}