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CYP gene polymorphisms and early menarche

Lai, Joe; Vesprini, Danny; Chu, William; Jernström, Helena LU and Narod, Steven A. (2001) In Molecular Genetics and Metabolism 74(4). p.449-457
Abstract
Early age at menarche is a risk factor for breast cancer. A previous study reported a significant positive association between the CYP3A4*1B variant allele and early puberty. We investigated whether polymorphisms of the CYP3A4, CYP17, CYP1B1, and CYP1A2 genes predict the age at onset of menarche. Five hundred eighty-three nulliparous women between ages 17 and 35, of various ethnic backgrounds, completed a questionnaire that included information about menstrual history. Samples of DNA were provided and used to genotype these women for polymorphic variants in the four genes. There was no significant difference in mean age at menarche between women who carried two variant CYP17 A2 alleles (12.5 years) and women who carried one or no variant... (More)
Early age at menarche is a risk factor for breast cancer. A previous study reported a significant positive association between the CYP3A4*1B variant allele and early puberty. We investigated whether polymorphisms of the CYP3A4, CYP17, CYP1B1, and CYP1A2 genes predict the age at onset of menarche. Five hundred eighty-three nulliparous women between ages 17 and 35, of various ethnic backgrounds, completed a questionnaire that included information about menstrual history. Samples of DNA were provided and used to genotype these women for polymorphic variants in the four genes. There was no significant difference in mean age at menarche between women who carried two variant CYP17 A2 alleles (12.5 years) and women who carried one or no variant allele (12.5 years) (P = 0.8, adjusted for ethnic group and year of birth). Similar results were found for the CYP1B1*3 variant allele and for the CYP1A2*1F variant allele. Women who carried two variant CYP3A4*1B alleles had an earlier mean age at menarche (12.0 years) than women who carried one or no variant allele (12.6 years) (P = 0.02). However, after adjusting for ethnic group and year of birth, no significant differences in mean age at menarche were found. The polymorphic variants of the CYP3A4, CYP17, CYP1B1, and CYP1A2 genes are unlikely to influence age of menarche. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
early menarche, genotype, CYP3A4, CYP17, CYP1B1, CYP1A2
in
Molecular Genetics and Metabolism
volume
74
issue
4
pages
449 - 457
publisher
Elsevier
external identifiers
  • pmid:11749050
  • wos:000173169200006
  • scopus:0035691747
ISSN
1096-7192
DOI
10.1006/mgme.2001.3260
language
English
LU publication?
yes
id
edd64075-ed56-428f-bc81-eb2b691a7d4c (old id 1120980)
date added to LUP
2008-07-03 08:31:04
date last changed
2018-01-07 05:40:37
@article{edd64075-ed56-428f-bc81-eb2b691a7d4c,
  abstract     = {Early age at menarche is a risk factor for breast cancer. A previous study reported a significant positive association between the CYP3A4*1B variant allele and early puberty. We investigated whether polymorphisms of the CYP3A4, CYP17, CYP1B1, and CYP1A2 genes predict the age at onset of menarche. Five hundred eighty-three nulliparous women between ages 17 and 35, of various ethnic backgrounds, completed a questionnaire that included information about menstrual history. Samples of DNA were provided and used to genotype these women for polymorphic variants in the four genes. There was no significant difference in mean age at menarche between women who carried two variant CYP17 A2 alleles (12.5 years) and women who carried one or no variant allele (12.5 years) (P = 0.8, adjusted for ethnic group and year of birth). Similar results were found for the CYP1B1*3 variant allele and for the CYP1A2*1F variant allele. Women who carried two variant CYP3A4*1B alleles had an earlier mean age at menarche (12.0 years) than women who carried one or no variant allele (12.6 years) (P = 0.02). However, after adjusting for ethnic group and year of birth, no significant differences in mean age at menarche were found. The polymorphic variants of the CYP3A4, CYP17, CYP1B1, and CYP1A2 genes are unlikely to influence age of menarche.},
  author       = {Lai, Joe and Vesprini, Danny and Chu, William and Jernström, Helena and Narod, Steven A.},
  issn         = {1096-7192},
  keyword      = {early menarche,genotype,CYP3A4,CYP17,CYP1B1,CYP1A2},
  language     = {eng},
  number       = {4},
  pages        = {449--457},
  publisher    = {Elsevier},
  series       = {Molecular Genetics and Metabolism},
  title        = {CYP gene polymorphisms and early menarche},
  url          = {http://dx.doi.org/10.1006/mgme.2001.3260},
  volume       = {74},
  year         = {2001},
}