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Steady-state pleural fluid flow and pressure and the effects of lung buoyancy

Haber, Richard; Grotberg, James B.; Glucksberg, Matthew R.; Miserocchi, Giuseppe; Venturoli, Daniele LU ; Del Fabbro, Massimo and Waters, Christopher M. (2001) In Journal of Biomechanical Engineering 123(5). p.485-492
Abstract
Both theoretical and experimental studies of pleural fluid dynamics and lung buoyancy during steady-state, apneic conditions are presented. The theory shows that steady-state, top-to-bottom pleural-liquid flow creates a pressure distribution that opposes lung buoyancy. These two forces may balance, permitting dynamic lung floating, but when they do not, pleural-pleural contact is required. The animal experiments examine pleural-liquid pressure distributions in response to simulated reduced gravity, achieved by lung inflation with perfluorocarbon liquid as compared to air. The resulting decrease in lung buoyancy modifies the force balance in the pleural fluid, which is reflected in its vertical pressure gradient. The data and model show... (More)
Both theoretical and experimental studies of pleural fluid dynamics and lung buoyancy during steady-state, apneic conditions are presented. The theory shows that steady-state, top-to-bottom pleural-liquid flow creates a pressure distribution that opposes lung buoyancy. These two forces may balance, permitting dynamic lung floating, but when they do not, pleural-pleural contact is required. The animal experiments examine pleural-liquid pressure distributions in response to simulated reduced gravity, achieved by lung inflation with perfluorocarbon liquid as compared to air. The resulting decrease in lung buoyancy modifies the force balance in the pleural fluid, which is reflected in its vertical pressure gradient. The data and model show that the decrease in buoyancy with perfluorocarbon inflation causes the vertical pressure gradient to approach hydrostatic. In the microgravity analogue, the pleural pressures would be toward a more uniform distribution, consistent with ventilation studies during space flight. The pleural liquid turnover predicted by the model is computed and found to be comparable to experimental values from the literature. The model provides the flow field, which can be used to develop a full transport theory for molecular and cellular constituents that are found in pleural fluid. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Biomechanical Engineering
volume
123
issue
5
pages
485 - 492
publisher
American Society Of Mechanical Engineers (ASME)
external identifiers
  • pmid:11601734
  • scopus:0034790954
ISSN
0148-0731
language
English
LU publication?
no
id
1f8ceaec-9cb9-4903-8107-9e16c2f87c1d (old id 1121316)
date added to LUP
2008-06-30 10:49:27
date last changed
2018-01-07 09:49:18
@article{1f8ceaec-9cb9-4903-8107-9e16c2f87c1d,
  abstract     = {Both theoretical and experimental studies of pleural fluid dynamics and lung buoyancy during steady-state, apneic conditions are presented. The theory shows that steady-state, top-to-bottom pleural-liquid flow creates a pressure distribution that opposes lung buoyancy. These two forces may balance, permitting dynamic lung floating, but when they do not, pleural-pleural contact is required. The animal experiments examine pleural-liquid pressure distributions in response to simulated reduced gravity, achieved by lung inflation with perfluorocarbon liquid as compared to air. The resulting decrease in lung buoyancy modifies the force balance in the pleural fluid, which is reflected in its vertical pressure gradient. The data and model show that the decrease in buoyancy with perfluorocarbon inflation causes the vertical pressure gradient to approach hydrostatic. In the microgravity analogue, the pleural pressures would be toward a more uniform distribution, consistent with ventilation studies during space flight. The pleural liquid turnover predicted by the model is computed and found to be comparable to experimental values from the literature. The model provides the flow field, which can be used to develop a full transport theory for molecular and cellular constituents that are found in pleural fluid.},
  author       = {Haber, Richard and Grotberg, James B. and Glucksberg, Matthew R. and Miserocchi, Giuseppe and Venturoli, Daniele and Del Fabbro, Massimo and Waters, Christopher M.},
  issn         = {0148-0731},
  language     = {eng},
  number       = {5},
  pages        = {485--492},
  publisher    = {American Society Of Mechanical Engineers (ASME)},
  series       = {Journal of Biomechanical Engineering},
  title        = {Steady-state pleural fluid flow and pressure and the effects of lung buoyancy},
  volume       = {123},
  year         = {2001},
}