Advanced

Der Einfluss von P-Fimbrien auf eine Leukozyturie und den Schwellenwert einer persistierenden Bakteriurie [Effect of P fimbriae on pyuria and bacterial colonization of the human urinary tract]

Wullt, Björn LU ; Bergsten, Göran LU ; Samuelsson, Martin LU and Svanborg, Catharina LU (2003) In Urologe: Ausgabe A 42(2). p.233-237
Abstract
This study investigated the role of P fimbriae in colonization of Escherichia coli, host response, and bacterial persistence in humans. Human volunteers were inoculated intravesically with the nonadherent ABU isolate E. coli 83972 and with P fimbriated transformants of the same strain. During the following 24 h all urine samples, and thereafter daily samples, were collected for urine culture, analysis of neutrophil numbers, and cytokine concentrations (IL-6 and IL-8). The P fimbriated transformants showed enhanced bacterial colonization in comparison to E. coli 83972 and lowered the bacterial numbers needed for persistent bacteriuria. The P fimbriated transformants also lowered the bacterial numbers needed for a significant neutrophil and... (More)
This study investigated the role of P fimbriae in colonization of Escherichia coli, host response, and bacterial persistence in humans. Human volunteers were inoculated intravesically with the nonadherent ABU isolate E. coli 83972 and with P fimbriated transformants of the same strain. During the following 24 h all urine samples, and thereafter daily samples, were collected for urine culture, analysis of neutrophil numbers, and cytokine concentrations (IL-6 and IL-8). The P fimbriated transformants showed enhanced bacterial colonization in comparison to E. coli 83972 and lowered the bacterial numbers needed for persistent bacteriuria. The P fimbriated transformants also lowered the bacterial numbers needed for a significant neutrophil and cytokine host response. We conclude that P fimbriae enhance bacterial colonization and trigger the host response in the human urinary tract. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
symptomatische Bakteriurie, E. coli 83972, P-Fimbrien, Harnwegsinfektionen, Wirtsreaktion
in
Urologe: Ausgabe A
volume
42
issue
2
pages
233 - 237
publisher
Springer
external identifiers
  • wos:000181640500008
  • pmid:12607092
  • scopus:0043199445
ISSN
0340-2592
DOI
language
German
LU publication?
yes
id
631b6053-666e-4059-9835-479430fcd08d (old id 112138)
date added to LUP
2007-07-18 13:16:10
date last changed
2018-05-29 09:40:57
@article{631b6053-666e-4059-9835-479430fcd08d,
  abstract     = {This study investigated the role of P fimbriae in colonization of Escherichia coli, host response, and bacterial persistence in humans. Human volunteers were inoculated intravesically with the nonadherent ABU isolate E. coli 83972 and with P fimbriated transformants of the same strain. During the following 24 h all urine samples, and thereafter daily samples, were collected for urine culture, analysis of neutrophil numbers, and cytokine concentrations (IL-6 and IL-8). The P fimbriated transformants showed enhanced bacterial colonization in comparison to E. coli 83972 and lowered the bacterial numbers needed for persistent bacteriuria. The P fimbriated transformants also lowered the bacterial numbers needed for a significant neutrophil and cytokine host response. We conclude that P fimbriae enhance bacterial colonization and trigger the host response in the human urinary tract.},
  author       = {Wullt, Björn and Bergsten, Göran and Samuelsson, Martin and Svanborg, Catharina},
  issn         = {0340-2592},
  keyword      = {symptomatische Bakteriurie,E. coli 83972,P-Fimbrien,Harnwegsinfektionen,Wirtsreaktion},
  language     = {ger},
  number       = {2},
  pages        = {233--237},
  publisher    = {Springer},
  series       = {Urologe: Ausgabe A},
  title        = {Der Einfluss von P-Fimbrien auf eine Leukozyturie und den Schwellenwert einer persistierenden Bakteriurie [Effect of P fimbriae on pyuria and bacterial colonization of the human urinary tract]},
  url          = {http://dx.doi.org/},
  volume       = {42},
  year         = {2003},
}