Der Einfluss von P-Fimbrien auf eine Leukozyturie und den Schwellenwert einer persistierenden Bakteriurie [Effect of P fimbriae on pyuria and bacterial colonization of the human urinary tract]
(2003) In Der Urologe 42(2). p.233-237- Abstract
- This study investigated the role of P fimbriae in colonization of Escherichia coli, host response, and bacterial persistence in humans. Human volunteers were inoculated intravesically with the nonadherent ABU isolate E. coli 83972 and with P fimbriated transformants of the same strain. During the following 24 h all urine samples, and thereafter daily samples, were collected for urine culture, analysis of neutrophil numbers, and cytokine concentrations (IL-6 and IL-8). The P fimbriated transformants showed enhanced bacterial colonization in comparison to E. coli 83972 and lowered the bacterial numbers needed for persistent bacteriuria. The P fimbriated transformants also lowered the bacterial numbers needed for a significant neutrophil and... (More)
- This study investigated the role of P fimbriae in colonization of Escherichia coli, host response, and bacterial persistence in humans. Human volunteers were inoculated intravesically with the nonadherent ABU isolate E. coli 83972 and with P fimbriated transformants of the same strain. During the following 24 h all urine samples, and thereafter daily samples, were collected for urine culture, analysis of neutrophil numbers, and cytokine concentrations (IL-6 and IL-8). The P fimbriated transformants showed enhanced bacterial colonization in comparison to E. coli 83972 and lowered the bacterial numbers needed for persistent bacteriuria. The P fimbriated transformants also lowered the bacterial numbers needed for a significant neutrophil and cytokine host response. We conclude that P fimbriae enhance bacterial colonization and trigger the host response in the human urinary tract. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/112138
- author
- Wullt, Björn LU ; Bergsten, Göran LU ; Samuelsson, Martin LU and Svanborg, Catharina LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- symptomatische Bakteriurie, E. coli 83972, P-Fimbrien, Harnwegsinfektionen, Wirtsreaktion
- in
- Der Urologe
- volume
- 42
- issue
- 2
- pages
- 233 - 237
- publisher
- Springer
- external identifiers
-
- wos:000181640500008
- pmid:12607092
- scopus:0043199445
- pmid:12607092
- ISSN
- 0340-2592
- DOI
- 10.1007/s00120-002-0287-y
- language
- German
- LU publication?
- yes
- id
- 631b6053-666e-4059-9835-479430fcd08d (old id 112138)
- date added to LUP
- 2016-04-01 12:05:53
- date last changed
- 2022-04-21 02:25:45
@article{631b6053-666e-4059-9835-479430fcd08d,
abstract = {{This study investigated the role of P fimbriae in colonization of Escherichia coli, host response, and bacterial persistence in humans. Human volunteers were inoculated intravesically with the nonadherent ABU isolate E. coli 83972 and with P fimbriated transformants of the same strain. During the following 24 h all urine samples, and thereafter daily samples, were collected for urine culture, analysis of neutrophil numbers, and cytokine concentrations (IL-6 and IL-8). The P fimbriated transformants showed enhanced bacterial colonization in comparison to E. coli 83972 and lowered the bacterial numbers needed for persistent bacteriuria. The P fimbriated transformants also lowered the bacterial numbers needed for a significant neutrophil and cytokine host response. We conclude that P fimbriae enhance bacterial colonization and trigger the host response in the human urinary tract.}},
author = {{Wullt, Björn and Bergsten, Göran and Samuelsson, Martin and Svanborg, Catharina}},
issn = {{0340-2592}},
keywords = {{symptomatische Bakteriurie; E. coli 83972; P-Fimbrien; Harnwegsinfektionen; Wirtsreaktion}},
language = {{ger}},
number = {{2}},
pages = {{233--237}},
publisher = {{Springer}},
series = {{Der Urologe}},
title = {{Der Einfluss von P-Fimbrien auf eine Leukozyturie und den Schwellenwert einer persistierenden Bakteriurie [Effect of P fimbriae on pyuria and bacterial colonization of the human urinary tract]}},
url = {{http://dx.doi.org/10.1007/s00120-002-0287-y}},
doi = {{10.1007/s00120-002-0287-y}},
volume = {{42}},
year = {{2003}},
}