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A new method to measure plasma levels of activated protein C in complex with protein C inhibitor in patients with acute coronary syndromes

Strandberg, K; Bhiladvala, P; Holm, Johan LU and Stenflo, Johan LU (2001) In Blood Coagulation and Fibrinolysis 12(7). p.503-510
Abstract
Our newly devised immunofluorometric sandwich assay for measuring plasma concentrations of activated protein C (APC) in complex with protein C inhibitor (PCI) was compared with testing for conventional markers of myocardial damage CKMB (creatine kinase MB), TNI (troponin I) and hypercoagulability (D-dimer, TAT) in 76 patients with suspected myocardial infarction (MI). APC-PCI complex levels in samples drawn on admission did not correlate with CKMB in the simultaneously drawn sample but correlated closely with maximal CKMB, which reflects MI size (r = 0.52). The areas under the receiver operating characteristics (ROC) curves calculated for the APC-PCI complex results obtained upon admission did not differ significantly from the... (More)
Our newly devised immunofluorometric sandwich assay for measuring plasma concentrations of activated protein C (APC) in complex with protein C inhibitor (PCI) was compared with testing for conventional markers of myocardial damage CKMB (creatine kinase MB), TNI (troponin I) and hypercoagulability (D-dimer, TAT) in 76 patients with suspected myocardial infarction (MI). APC-PCI complex levels in samples drawn on admission did not correlate with CKMB in the simultaneously drawn sample but correlated closely with maximal CKMB, which reflects MI size (r = 0.52). The areas under the receiver operating characteristics (ROC) curves calculated for the APC-PCI complex results obtained upon admission did not differ significantly from the corresponding values for CKMB, TNI or TAT. Our results show that in patients at risk for MI, the APC-PCI concentration is a sensitive and independent marker that can identify a subgroup of MI patients with normal CKMB but an increased APC-PCI level upon admission. It remains to be determined whether these patients would benefit from early intensive anticoagulant treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood Coagulation and Fibrinolysis
volume
12
issue
7
pages
503 - 510
publisher
Lippincott Williams and Wilkins
external identifiers
  • pmid:11685037
  • scopus:0034750116
ISSN
1473-5733
language
English
LU publication?
yes
id
815b1903-01fc-4d73-ae2e-bf8a7edaeea5 (old id 1121488)
date added to LUP
2008-07-15 10:56:33
date last changed
2018-05-29 10:01:09
@article{815b1903-01fc-4d73-ae2e-bf8a7edaeea5,
  abstract     = {Our newly devised immunofluorometric sandwich assay for measuring plasma concentrations of activated protein C (APC) in complex with protein C inhibitor (PCI) was compared with testing for conventional markers of myocardial damage CKMB (creatine kinase MB), TNI (troponin I) and hypercoagulability (D-dimer, TAT) in 76 patients with suspected myocardial infarction (MI). APC-PCI complex levels in samples drawn on admission did not correlate with CKMB in the simultaneously drawn sample but correlated closely with maximal CKMB, which reflects MI size (r = 0.52). The areas under the receiver operating characteristics (ROC) curves calculated for the APC-PCI complex results obtained upon admission did not differ significantly from the corresponding values for CKMB, TNI or TAT. Our results show that in patients at risk for MI, the APC-PCI concentration is a sensitive and independent marker that can identify a subgroup of MI patients with normal CKMB but an increased APC-PCI level upon admission. It remains to be determined whether these patients would benefit from early intensive anticoagulant treatment.},
  author       = {Strandberg, K and Bhiladvala, P and Holm, Johan and Stenflo, Johan},
  issn         = {1473-5733},
  language     = {eng},
  number       = {7},
  pages        = {503--510},
  publisher    = {Lippincott Williams and Wilkins},
  series       = {Blood Coagulation and Fibrinolysis},
  title        = {A new method to measure plasma levels of activated protein C in complex with protein C inhibitor in patients with acute coronary syndromes},
  volume       = {12},
  year         = {2001},
}