Patch testing with serial dilutions of budesonide, its R and S diastereomers, and potentially cross-reacting substances
(2001) In American Journal of Contact Dermatitis 12(3). p.170-176- Abstract
- BACKGROUND: Budesonide, a marker for corticosteroid allergy, is a 1:1 mixture of 2 diastereomers, the R and S, present in all commercial formulations. Budesonide is said to cross-react with group B substances through the R and S diastereomer and some group D substances only through the S diastereomer. OBJECTIVE: To investigate the cross-reactivity pattern between the R and S diastereomers and 4 potentially cross-reacting substances, 2 from group B and 2 from group D. METHODS: By patch testing 10 patients hypersensitive to budesonide with a serial dilution of budesonide, the R and S diastereomer, triamcinolone acetonide, amcinonide, prednicarbate, and hydrocortisone-17-butyrate. RESULTS: Nine of 10 patients reacted to budesonide and the S... (More)
- BACKGROUND: Budesonide, a marker for corticosteroid allergy, is a 1:1 mixture of 2 diastereomers, the R and S, present in all commercial formulations. Budesonide is said to cross-react with group B substances through the R and S diastereomer and some group D substances only through the S diastereomer. OBJECTIVE: To investigate the cross-reactivity pattern between the R and S diastereomers and 4 potentially cross-reacting substances, 2 from group B and 2 from group D. METHODS: By patch testing 10 patients hypersensitive to budesonide with a serial dilution of budesonide, the R and S diastereomer, triamcinolone acetonide, amcinonide, prednicarbate, and hydrocortisone-17-butyrate. RESULTS: Nine of 10 patients reacted to budesonide and the S diastereomer. Seven of 9 to the R diastereomer. Each of the 9 patients with S diastereomer allergy reacted to the group B and/or group D substances. Five patients reacted to triamcinolone acetonide, not to 1.0% but only to 0.0010% and 0.00010%. CONCLUSION: The R and S diastereomers can induce positive patch test reactions in budesonide-hypersensitive individuals. The potential of budesonide to cross-react with substances from group B and D might be explained by the presence of the 2 diastereomers. When patch testing with triamcinolone acetonide, much lower concentrations than recommended should be used. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121506
- author
- Isaksson, M ; Bruze, Magnus LU ; Lepoittevin, Jean-Pierre and Goossens, An
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Contact Dermatitis
- volume
- 12
- issue
- 3
- pages
- 170 - 176
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:11526524
- scopus:0034827351
- ISSN
- 1046-199X
- DOI
- 10.1053/ajcd.2001.20553
- language
- English
- LU publication?
- yes
- id
- b5edbcb0-2328-4276-92ab-d00aea40bf4d (old id 1121506)
- date added to LUP
- 2016-04-01 16:21:04
- date last changed
- 2022-01-28 19:06:47
@article{b5edbcb0-2328-4276-92ab-d00aea40bf4d, abstract = {{BACKGROUND: Budesonide, a marker for corticosteroid allergy, is a 1:1 mixture of 2 diastereomers, the R and S, present in all commercial formulations. Budesonide is said to cross-react with group B substances through the R and S diastereomer and some group D substances only through the S diastereomer. OBJECTIVE: To investigate the cross-reactivity pattern between the R and S diastereomers and 4 potentially cross-reacting substances, 2 from group B and 2 from group D. METHODS: By patch testing 10 patients hypersensitive to budesonide with a serial dilution of budesonide, the R and S diastereomer, triamcinolone acetonide, amcinonide, prednicarbate, and hydrocortisone-17-butyrate. RESULTS: Nine of 10 patients reacted to budesonide and the S diastereomer. Seven of 9 to the R diastereomer. Each of the 9 patients with S diastereomer allergy reacted to the group B and/or group D substances. Five patients reacted to triamcinolone acetonide, not to 1.0% but only to 0.0010% and 0.00010%. CONCLUSION: The R and S diastereomers can induce positive patch test reactions in budesonide-hypersensitive individuals. The potential of budesonide to cross-react with substances from group B and D might be explained by the presence of the 2 diastereomers. When patch testing with triamcinolone acetonide, much lower concentrations than recommended should be used.}}, author = {{Isaksson, M and Bruze, Magnus and Lepoittevin, Jean-Pierre and Goossens, An}}, issn = {{1046-199X}}, language = {{eng}}, number = {{3}}, pages = {{170--176}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{American Journal of Contact Dermatitis}}, title = {{Patch testing with serial dilutions of budesonide, its R and S diastereomers, and potentially cross-reacting substances}}, url = {{http://dx.doi.org/10.1053/ajcd.2001.20553}}, doi = {{10.1053/ajcd.2001.20553}}, volume = {{12}}, year = {{2001}}, }