Repetitive usage testing with budesonide in experimental nickel--allergic contact dermatitis in individuals hypersensitive to budesonide
(2001) In British Journal of Dermatology 145(1). p.38-44- Abstract
- BACKGROUND: Contact allergy to topical corticosteroids on patch testing is well recognized, but the clinical significance is uncertain. OBJECTIVES: To determine the clinical relevance of contact allergy to topical corticosteroids. METHODS: Seven patients hypersensitive to both budesonide and nickel repeatedly applied budesonide, betamethasone valerate or the common base for both corticosteroids to areas of experimentally induced nickel dermatitis. Nineteen controls allergic to nickel, but not budesonide went through the same procedure. RESULTS: Seventy-one per cent of the budesonide-allergic individuals experienced distant ipsilateral flares of toxicoderma-like eruptions, in addition to a severe deterioration of the experimental dermatitis... (More)
- BACKGROUND: Contact allergy to topical corticosteroids on patch testing is well recognized, but the clinical significance is uncertain. OBJECTIVES: To determine the clinical relevance of contact allergy to topical corticosteroids. METHODS: Seven patients hypersensitive to both budesonide and nickel repeatedly applied budesonide, betamethasone valerate or the common base for both corticosteroids to areas of experimentally induced nickel dermatitis. Nineteen controls allergic to nickel, but not budesonide went through the same procedure. RESULTS: Seventy-one per cent of the budesonide-allergic individuals experienced distant ipsilateral flares of toxicoderma-like eruptions, in addition to a severe deterioration of the experimental dermatitis treated with budesonide, i.e. increased erythema, and abundant papules and vesicles. The areas of dermatitis in all of the 19 controls healed uneventfully. CONCLUSIONS: The clinical relevance of a contact allergy to budesonide was thus substantiated. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121510
- author
- Isaksson, M and Bruze, Magnus LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Dermatology
- volume
- 145
- issue
- 1
- pages
- 38 - 44
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:11453905
- scopus:0034818545
- ISSN
- 1365-2133
- DOI
- 10.1046/j.1365-2133.2001.04279.x
- language
- English
- LU publication?
- yes
- id
- 69f733b1-8d07-454e-98c9-acb48498f73d (old id 1121510)
- date added to LUP
- 2016-04-01 11:50:52
- date last changed
- 2022-03-28 03:53:49
@article{69f733b1-8d07-454e-98c9-acb48498f73d, abstract = {{BACKGROUND: Contact allergy to topical corticosteroids on patch testing is well recognized, but the clinical significance is uncertain. OBJECTIVES: To determine the clinical relevance of contact allergy to topical corticosteroids. METHODS: Seven patients hypersensitive to both budesonide and nickel repeatedly applied budesonide, betamethasone valerate or the common base for both corticosteroids to areas of experimentally induced nickel dermatitis. Nineteen controls allergic to nickel, but not budesonide went through the same procedure. RESULTS: Seventy-one per cent of the budesonide-allergic individuals experienced distant ipsilateral flares of toxicoderma-like eruptions, in addition to a severe deterioration of the experimental dermatitis treated with budesonide, i.e. increased erythema, and abundant papules and vesicles. The areas of dermatitis in all of the 19 controls healed uneventfully. CONCLUSIONS: The clinical relevance of a contact allergy to budesonide was thus substantiated.}}, author = {{Isaksson, M and Bruze, Magnus}}, issn = {{1365-2133}}, language = {{eng}}, number = {{1}}, pages = {{38--44}}, publisher = {{Wiley-Blackwell}}, series = {{British Journal of Dermatology}}, title = {{Repetitive usage testing with budesonide in experimental nickel--allergic contact dermatitis in individuals hypersensitive to budesonide}}, url = {{http://dx.doi.org/10.1046/j.1365-2133.2001.04279.x}}, doi = {{10.1046/j.1365-2133.2001.04279.x}}, volume = {{145}}, year = {{2001}}, }