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Molecular and pathological characterization of inherited breast cancer.

Borg, Åke LU (2001) In Seminars in Cancer Biology 11(5). p.375-385
Abstract
The two major breast cancer susceptibility genes, BRCA1 and BRCA2, account for the majority of familial breast–ovarian cancer, but only a modest proportion of breast cancer families without ovarian or male breast cancer. Search for additional breast cancer genes with traditional linkage analysis has so far been unsuccessful, probably due to genetic heterogeneity. Pooling of families of different ethnical, cultural, and geographical origin proved to be a useful approach when identifying BRCA1 and BRCA2, but for genes mutated only in specific populations it is important not to introduce locus heterogeneity by pooling. Genetic heterogeneity can possibly be circumvented by using objective means, such as tumour histopathology or gene expression... (More)
The two major breast cancer susceptibility genes, BRCA1 and BRCA2, account for the majority of familial breast–ovarian cancer, but only a modest proportion of breast cancer families without ovarian or male breast cancer. Search for additional breast cancer genes with traditional linkage analysis has so far been unsuccessful, probably due to genetic heterogeneity. Pooling of families of different ethnical, cultural, and geographical origin proved to be a useful approach when identifying BRCA1 and BRCA2, but for genes mutated only in specific populations it is important not to introduce locus heterogeneity by pooling. Genetic heterogeneity can possibly be circumvented by using objective means, such as tumour histopathology or gene expression profiling, for subclassification of families prior to linkage analysis. Also, additional breast cancer genes can be identified by further characterization of the function of BRCA1 and BRCA2 and their interacting proteins. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breast cancer, BRCA1, BRCA2, molecular characterization, pathological characterization
in
Seminars in Cancer Biology
volume
11
issue
5
pages
375 - 385
publisher
Academic Press
external identifiers
  • WOS:000171560700007
  • Scopus:0034751402
ISSN
1096-3650
DOI
10.1006/scbi.2001.0393
language
English
LU publication?
yes
id
c3b49d92-c523-4dc3-8a45-bc67e97b3284 (old id 1121626)
date added to LUP
2008-06-25 12:34:26
date last changed
2017-01-01 08:04:51
@article{c3b49d92-c523-4dc3-8a45-bc67e97b3284,
  abstract     = {The two major breast cancer susceptibility genes, BRCA1 and BRCA2, account for the majority of familial breast–ovarian cancer, but only a modest proportion of breast cancer families without ovarian or male breast cancer. Search for additional breast cancer genes with traditional linkage analysis has so far been unsuccessful, probably due to genetic heterogeneity. Pooling of families of different ethnical, cultural, and geographical origin proved to be a useful approach when identifying BRCA1 and BRCA2, but for genes mutated only in specific populations it is important not to introduce locus heterogeneity by pooling. Genetic heterogeneity can possibly be circumvented by using objective means, such as tumour histopathology or gene expression profiling, for subclassification of families prior to linkage analysis. Also, additional breast cancer genes can be identified by further characterization of the function of BRCA1 and BRCA2 and their interacting proteins.},
  author       = {Borg, Åke},
  issn         = {1096-3650},
  keyword      = {breast cancer,BRCA1,BRCA2,molecular characterization,pathological characterization},
  language     = {eng},
  number       = {5},
  pages        = {375--385},
  publisher    = {Academic Press},
  series       = {Seminars in Cancer Biology},
  title        = {Molecular and pathological characterization of inherited breast cancer.},
  url          = {http://dx.doi.org/10.1006/scbi.2001.0393},
  volume       = {11},
  year         = {2001},
}