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Novel distribution of the secretory leucocyte proteinase inhibitor in kidney

Ohlsson, Sophie LU orcid ; Ljungkrantz, Irena ; Ohlsson, Kjell ; Segelmark, Mårten LU and Wieslander, Jörgen LU (2001) In Mediators of Inflammation 10(6). p.347-350
Abstract
The secretory leucocyte proteinase inhibitor (SLPI) is a low molecular weight, tissue-specific inhibitor of, for example, elastase and cathepsin G, which also have antimicrobial capacity. SLPI has been localised to the respiratory, gastrointestinal and genital tracts, but so far not to the kidney. The presence of SLPI in renal tubuli cells was demonstrated using immunohistochemistry and, by means of in situ hybridisation on human renal biopsies, we were able to demonstrate SLPI production. In various inflammatory conditions in the kidneys, the protease-antiprotease balance is disturbed. For this reason, as well as the possible role in the defence against ascending urinary tract infections, it is interesting to establish a source of SLPI in... (More)
The secretory leucocyte proteinase inhibitor (SLPI) is a low molecular weight, tissue-specific inhibitor of, for example, elastase and cathepsin G, which also have antimicrobial capacity. SLPI has been localised to the respiratory, gastrointestinal and genital tracts, but so far not to the kidney. The presence of SLPI in renal tubuli cells was demonstrated using immunohistochemistry and, by means of in situ hybridisation on human renal biopsies, we were able to demonstrate SLPI production. In various inflammatory conditions in the kidneys, the protease-antiprotease balance is disturbed. For this reason, as well as the possible role in the defence against ascending urinary tract infections, it is interesting to establish a source of SLPI in renal tubuli cells. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Glomerulonephritis, Kidney, Protease inhibitor, SLPI, Anti-leukoprotease
in
Mediators of Inflammation
volume
10
issue
6
pages
347 - 350
publisher
Hindawi Limited
external identifiers
  • pmid:11817677
  • scopus:0035696748
ISSN
0962-9351
DOI
10.1080/09629350120102389
language
English
LU publication?
yes
id
1789d928-d5d9-4bcc-b1c1-2ded8f2791a3 (old id 1121629)
date added to LUP
2016-04-01 11:46:46
date last changed
2022-02-25 21:13:31
@article{1789d928-d5d9-4bcc-b1c1-2ded8f2791a3,
  abstract     = {{The secretory leucocyte proteinase inhibitor (SLPI) is a low molecular weight, tissue-specific inhibitor of, for example, elastase and cathepsin G, which also have antimicrobial capacity. SLPI has been localised to the respiratory, gastrointestinal and genital tracts, but so far not to the kidney. The presence of SLPI in renal tubuli cells was demonstrated using immunohistochemistry and, by means of in situ hybridisation on human renal biopsies, we were able to demonstrate SLPI production. In various inflammatory conditions in the kidneys, the protease-antiprotease balance is disturbed. For this reason, as well as the possible role in the defence against ascending urinary tract infections, it is interesting to establish a source of SLPI in renal tubuli cells.}},
  author       = {{Ohlsson, Sophie and Ljungkrantz, Irena and Ohlsson, Kjell and Segelmark, Mårten and Wieslander, Jörgen}},
  issn         = {{0962-9351}},
  keywords     = {{Glomerulonephritis; Kidney; Protease inhibitor; SLPI; Anti-leukoprotease}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{347--350}},
  publisher    = {{Hindawi Limited}},
  series       = {{Mediators of Inflammation}},
  title        = {{Novel distribution of the secretory leucocyte proteinase inhibitor in kidney}},
  url          = {{http://dx.doi.org/10.1080/09629350120102389}},
  doi          = {{10.1080/09629350120102389}},
  volume       = {{10}},
  year         = {{2001}},
}