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Flare-up reactions after oral challenge with nickel in relation to challenge dose and intensity and time of previous patch test reactions

Hindsén, Monica LU ; Bruze, Magnus LU and Christensen, O B (2001) In Journal of American Academy of Dermatology 44(4). p.616-623
Abstract
BACKGROUND: In this study we have taken an interest in systemic exposure to nickel in patients with delayed hypersensitivity to nickel. OBJECTIVE: The aim of the study was to more closely investigate the importance of factors such as ingested nickel dose, time interval between nickel patch testing and oral nickel challenge as well as degree of nickel hypersensitivity in relation to flare-up reactions. METHODS: Thirty nickel-sensitive female subjects were patch tested with a serial dilution of nickel sulfate in water on 4 different test occasions during a period of 7 months. One month after the last patch test the patients were randomly divided into 3 different groups. The patients in the groups were challenged orally with a placebo... (More)
BACKGROUND: In this study we have taken an interest in systemic exposure to nickel in patients with delayed hypersensitivity to nickel. OBJECTIVE: The aim of the study was to more closely investigate the importance of factors such as ingested nickel dose, time interval between nickel patch testing and oral nickel challenge as well as degree of nickel hypersensitivity in relation to flare-up reactions. METHODS: Thirty nickel-sensitive female subjects were patch tested with a serial dilution of nickel sulfate in water on 4 different test occasions during a period of 7 months. One month after the last patch test the patients were randomly divided into 3 different groups. The patients in the groups were challenged orally with a placebo capsule, 1.0 mg nickel, or 3.0 mg nickel. RESULTS: None of the patients challenged with placebo had flare-up reactions of earlier patch test sites, but 2 of the patients challenged with 1.0 mg nickel and all of the patients challenged with 3.0 mg nickel had flare-up reactions. There were significantly more flare-up reactions of the most recent patch test sites (1 month) compared with the most distant (8 months) test sites. There was also a statistically significant positive correlation between the intensity of previous positive patch tests and the flare-up reactions. CONCLUSION: In the assessment of the possibility of systemic allergic contact dermatitis from nickel, the dose as well as the intensity and time since previous nickel eczema have to be considered. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of American Academy of Dermatology
volume
44
issue
4
pages
616 - 623
publisher
Elsevier
external identifiers
  • pmid:11260535
  • scopus:0035088826
ISSN
0190-9622
DOI
10.1067/mjd.2001.110873
language
English
LU publication?
yes
id
acb8c1ab-b1d1-4a7a-906b-9af8672de89b (old id 1121690)
date added to LUP
2008-06-30 14:13:36
date last changed
2018-10-07 03:37:30
@article{acb8c1ab-b1d1-4a7a-906b-9af8672de89b,
  abstract     = {BACKGROUND: In this study we have taken an interest in systemic exposure to nickel in patients with delayed hypersensitivity to nickel. OBJECTIVE: The aim of the study was to more closely investigate the importance of factors such as ingested nickel dose, time interval between nickel patch testing and oral nickel challenge as well as degree of nickel hypersensitivity in relation to flare-up reactions. METHODS: Thirty nickel-sensitive female subjects were patch tested with a serial dilution of nickel sulfate in water on 4 different test occasions during a period of 7 months. One month after the last patch test the patients were randomly divided into 3 different groups. The patients in the groups were challenged orally with a placebo capsule, 1.0 mg nickel, or 3.0 mg nickel. RESULTS: None of the patients challenged with placebo had flare-up reactions of earlier patch test sites, but 2 of the patients challenged with 1.0 mg nickel and all of the patients challenged with 3.0 mg nickel had flare-up reactions. There were significantly more flare-up reactions of the most recent patch test sites (1 month) compared with the most distant (8 months) test sites. There was also a statistically significant positive correlation between the intensity of previous positive patch tests and the flare-up reactions. CONCLUSION: In the assessment of the possibility of systemic allergic contact dermatitis from nickel, the dose as well as the intensity and time since previous nickel eczema have to be considered.},
  author       = {Hindsén, Monica and Bruze, Magnus and Christensen, O B},
  issn         = {0190-9622},
  language     = {eng},
  number       = {4},
  pages        = {616--623},
  publisher    = {Elsevier},
  series       = {Journal of American Academy of Dermatology},
  title        = {Flare-up reactions after oral challenge with nickel in relation to challenge dose and intensity and time of previous patch test reactions},
  url          = {http://dx.doi.org/10.1067/mjd.2001.110873},
  volume       = {44},
  year         = {2001},
}