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Increased level of soluble HLA class I antigens in systemic lupus erythematosus: correlation with anti-DNA antibodies and leukopenia

Kippner, Linda ; Klint, Cecilia LU ; Sturfelt, Gunnar LU ; Bengtsson, Anders LU ; Eriksson, Håkan and Truedsson, Lennart LU (2001) In Journal of Autoimmunity 16(4). p.471-478
Abstract
The concentration of soluble HLA class I (sHLA-I) was measured by ELISA in serum samples from 30 well-characterised SLE patients at high and low disease activity states and from 100 healthy controls. HLA-A allotypes in the patients were analysed by a PCR-based typing technique. A higher level of sHLA-I was found in SLE patient sera both at high and low disease activity than in controls (P< 0.001). The sHLA-I level was further increased during active disease (P< 0.01). Concentrations of sHLA-I correlated with anti-dsDNA antibodies at high disease activity, but not with disease activity as analysed by a modified SLEDAI. Numbers of leukocytes and lymphocytes, as well as levels of C1q and C3 correlated inversely with sHLA-I... (More)
The concentration of soluble HLA class I (sHLA-I) was measured by ELISA in serum samples from 30 well-characterised SLE patients at high and low disease activity states and from 100 healthy controls. HLA-A allotypes in the patients were analysed by a PCR-based typing technique. A higher level of sHLA-I was found in SLE patient sera both at high and low disease activity than in controls (P< 0.001). The sHLA-I level was further increased during active disease (P< 0.01). Concentrations of sHLA-I correlated with anti-dsDNA antibodies at high disease activity, but not with disease activity as analysed by a modified SLEDAI. Numbers of leukocytes and lymphocytes, as well as levels of C1q and C3 correlated inversely with sHLA-I concentration. In five serial samples from ten patients the sHLA-I level co-varied with disease activity. Presence of HLA allotype A9 was associated with higher sHLA-I levels in both patients (P< 0.001) and controls (P< 0.001). We conclude that the increased sHLA-I concentration in SLE patients was related to several laboratory parameters reflecting disease activity suggesting that sHLA-I molecules are connected with the disease process. Increased sHLA-I level due to HLA-A allotype was not a disease susceptibility factor for SLE. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
soluble HLA class I, systemic lupus erythematosus, complement, autoantibodies, HLA allotype
in
Journal of Autoimmunity
volume
16
issue
4
pages
471 - 478
publisher
Elsevier
external identifiers
  • scopus:0034955037
  • pmid:11437496
  • pmid:11437496
ISSN
0896-8411
DOI
10.1006/jaut.2001.0509
language
English
LU publication?
yes
id
d17e1044-d48a-4dce-b36e-af98873b79db (old id 1121752)
date added to LUP
2016-04-01 11:41:45
date last changed
2022-03-28 01:47:47
@article{d17e1044-d48a-4dce-b36e-af98873b79db,
  abstract     = {{The concentration of soluble HLA class I (sHLA-I) was measured by ELISA in serum samples from 30 well-characterised SLE patients at high and low disease activity states and from 100 healthy controls. HLA-A allotypes in the patients were analysed by a PCR-based typing technique. A higher level of sHLA-I was found in SLE patient sera both at high and low disease activity than in controls (P&lt; 0.001). The sHLA-I level was further increased during active disease (P&lt; 0.01). Concentrations of sHLA-I correlated with anti-dsDNA antibodies at high disease activity, but not with disease activity as analysed by a modified SLEDAI. Numbers of leukocytes and lymphocytes, as well as levels of C1q and C3 correlated inversely with sHLA-I concentration. In five serial samples from ten patients the sHLA-I level co-varied with disease activity. Presence of HLA allotype A9 was associated with higher sHLA-I levels in both patients (P&lt; 0.001) and controls (P&lt; 0.001). We conclude that the increased sHLA-I concentration in SLE patients was related to several laboratory parameters reflecting disease activity suggesting that sHLA-I molecules are connected with the disease process. Increased sHLA-I level due to HLA-A allotype was not a disease susceptibility factor for SLE.}},
  author       = {{Kippner, Linda and Klint, Cecilia and Sturfelt, Gunnar and Bengtsson, Anders and Eriksson, Håkan and Truedsson, Lennart}},
  issn         = {{0896-8411}},
  keywords     = {{soluble HLA class I; systemic lupus erythematosus; complement; autoantibodies; HLA allotype}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{471--478}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Autoimmunity}},
  title        = {{Increased level of soluble HLA class I antigens in systemic lupus erythematosus: correlation with anti-DNA antibodies and leukopenia}},
  url          = {{http://dx.doi.org/10.1006/jaut.2001.0509}},
  doi          = {{10.1006/jaut.2001.0509}},
  volume       = {{16}},
  year         = {{2001}},
}