Increased level of soluble HLA class I antigens in systemic lupus erythematosus: correlation with anti-DNA antibodies and leukopenia
(2001) In Journal of Autoimmunity 16(4). p.471-478- Abstract
- The concentration of soluble HLA class I (sHLA-I) was measured by ELISA in serum samples from 30 well-characterised SLE patients at high and low disease activity states and from 100 healthy controls. HLA-A allotypes in the patients were analysed by a PCR-based typing technique. A higher level of sHLA-I was found in SLE patient sera both at high and low disease activity than in controls (P< 0.001). The sHLA-I level was further increased during active disease (P< 0.01). Concentrations of sHLA-I correlated with anti-dsDNA antibodies at high disease activity, but not with disease activity as analysed by a modified SLEDAI. Numbers of leukocytes and lymphocytes, as well as levels of C1q and C3 correlated inversely with sHLA-I... (More)
- The concentration of soluble HLA class I (sHLA-I) was measured by ELISA in serum samples from 30 well-characterised SLE patients at high and low disease activity states and from 100 healthy controls. HLA-A allotypes in the patients were analysed by a PCR-based typing technique. A higher level of sHLA-I was found in SLE patient sera both at high and low disease activity than in controls (P< 0.001). The sHLA-I level was further increased during active disease (P< 0.01). Concentrations of sHLA-I correlated with anti-dsDNA antibodies at high disease activity, but not with disease activity as analysed by a modified SLEDAI. Numbers of leukocytes and lymphocytes, as well as levels of C1q and C3 correlated inversely with sHLA-I concentration. In five serial samples from ten patients the sHLA-I level co-varied with disease activity. Presence of HLA allotype A9 was associated with higher sHLA-I levels in both patients (P< 0.001) and controls (P< 0.001). We conclude that the increased sHLA-I concentration in SLE patients was related to several laboratory parameters reflecting disease activity suggesting that sHLA-I molecules are connected with the disease process. Increased sHLA-I level due to HLA-A allotype was not a disease susceptibility factor for SLE. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121752
- author
- Kippner, Linda ; Klint, Cecilia LU ; Sturfelt, Gunnar LU ; Bengtsson, Anders LU ; Eriksson, Håkan and Truedsson, Lennart LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- soluble HLA class I, systemic lupus erythematosus, complement, autoantibodies, HLA allotype
- in
- Journal of Autoimmunity
- volume
- 16
- issue
- 4
- pages
- 471 - 478
- publisher
- Academic Press
- external identifiers
-
- scopus:0034955037
- pmid:11437496
- pmid:11437496
- ISSN
- 0896-8411
- DOI
- 10.1006/jaut.2001.0509
- language
- English
- LU publication?
- yes
- id
- d17e1044-d48a-4dce-b36e-af98873b79db (old id 1121752)
- date added to LUP
- 2016-04-01 11:41:45
- date last changed
- 2025-04-04 14:41:31
@article{d17e1044-d48a-4dce-b36e-af98873b79db, abstract = {{The concentration of soluble HLA class I (sHLA-I) was measured by ELISA in serum samples from 30 well-characterised SLE patients at high and low disease activity states and from 100 healthy controls. HLA-A allotypes in the patients were analysed by a PCR-based typing technique. A higher level of sHLA-I was found in SLE patient sera both at high and low disease activity than in controls (P< 0.001). The sHLA-I level was further increased during active disease (P< 0.01). Concentrations of sHLA-I correlated with anti-dsDNA antibodies at high disease activity, but not with disease activity as analysed by a modified SLEDAI. Numbers of leukocytes and lymphocytes, as well as levels of C1q and C3 correlated inversely with sHLA-I concentration. In five serial samples from ten patients the sHLA-I level co-varied with disease activity. Presence of HLA allotype A9 was associated with higher sHLA-I levels in both patients (P< 0.001) and controls (P< 0.001). We conclude that the increased sHLA-I concentration in SLE patients was related to several laboratory parameters reflecting disease activity suggesting that sHLA-I molecules are connected with the disease process. Increased sHLA-I level due to HLA-A allotype was not a disease susceptibility factor for SLE.}}, author = {{Kippner, Linda and Klint, Cecilia and Sturfelt, Gunnar and Bengtsson, Anders and Eriksson, Håkan and Truedsson, Lennart}}, issn = {{0896-8411}}, keywords = {{soluble HLA class I; systemic lupus erythematosus; complement; autoantibodies; HLA allotype}}, language = {{eng}}, number = {{4}}, pages = {{471--478}}, publisher = {{Academic Press}}, series = {{Journal of Autoimmunity}}, title = {{Increased level of soluble HLA class I antigens in systemic lupus erythematosus: correlation with anti-DNA antibodies and leukopenia}}, url = {{http://dx.doi.org/10.1006/jaut.2001.0509}}, doi = {{10.1006/jaut.2001.0509}}, volume = {{16}}, year = {{2001}}, }