Protection against cold air and exercise-induced bronchoconstriction while on regular treatment with Oxis
Vilsvik, J ; Ankerst, Jaro LU
; Palmqvist, M
; Persson, G
; Schaanning, J
; Schwabe, G
and Johansson, A
(2001)
In Respiratory Medicine
95(6).
p.484-490
- Abstract
- This study aimed to compare the duration of protection against exercise-induced bronchoconstriction (EIB) after inhalation of formoterol (Oxis) Turbuhaler with that of terbutaline Turbuhaler and placebo Turbuhaler in asthmatic patients treated regularly with formoterol Turbuhaler 9 microg b.i.d. and inhaled steroids. The study. performed at three centres (Goteborg and Lund, Sweden, and Trondheim, Norway), consisted of an open-label part with formoterol Turbuhaler 9 microg b.i.d. and a randomized, double-blind, cross-over part with a single dose (on top of the regular treatment) of either formoterol Turbuhaler 9 microg, terbutaline Turbuhaler 0.5 mg or placebo Turbuhaler. The patients attended the clinic six times: twice for screening... (More)
- This study aimed to compare the duration of protection against exercise-induced bronchoconstriction (EIB) after inhalation of formoterol (Oxis) Turbuhaler with that of terbutaline Turbuhaler and placebo Turbuhaler in asthmatic patients treated regularly with formoterol Turbuhaler 9 microg b.i.d. and inhaled steroids. The study. performed at three centres (Goteborg and Lund, Sweden, and Trondheim, Norway), consisted of an open-label part with formoterol Turbuhaler 9 microg b.i.d. and a randomized, double-blind, cross-over part with a single dose (on top of the regular treatment) of either formoterol Turbuhaler 9 microg, terbutaline Turbuhaler 0.5 mg or placebo Turbuhaler. The patients attended the clinic six times: twice for screening visits, three times for randomized treatment and once for a follow-up visit. Patients received regular b.i.d. treatment with formoterol 9 microg for a mean period of 16 days. Formoterol gave a post-exercise fall of 12, 10, 15 and 17% in forced expiratory volume in 1 sec (FEV1) 15 min, 4, 8 and 12 h after inhalation. The differences compared with placebo (falls of 26, 22, 23 and 22%) and terbutaline (falls of 17, 18, 22 and 22%) were all statistically significant (P<0.05 for all comparisons). Patients on regular treatment with formoterol Turbuhaler 9 microg b.i.d. have a significant protection against EIB up to 12 h after inhalation of formoterol 9 microg. The protection was also significantly better than that of terbutaline Turbuhaler 0.5 mg. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121922
- author
- Vilsvik, J
; Ankerst, Jaro
LU
; Palmqvist, M
; Persson, G
; Schaanning, J
; Schwabe, G
and Johansson, A
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- formoterol turbuhaler®, asthma, exercise, cold air.
- in
- Respiratory Medicine
- volume
- 95
- issue
- 6
- pages
- 484 - 490
- publisher
- Elsevier
- external identifiers
-
- pmid:11421506
- scopus:0034938767
- ISSN
- 1532-3064
- DOI
- 10.1053/rmed.2001.1074
- language
- English
- LU publication?
- yes
- id
- 87a9c16c-8ed1-4b4f-8223-d4c766876809 (old id 1121922)
- date added to LUP
- 2016-04-01 16:20:00
- date last changed
- 2022-01-28 18:55:56
@article{87a9c16c-8ed1-4b4f-8223-d4c766876809,
abstract = {{This study aimed to compare the duration of protection against exercise-induced bronchoconstriction (EIB) after inhalation of formoterol (Oxis) Turbuhaler with that of terbutaline Turbuhaler and placebo Turbuhaler in asthmatic patients treated regularly with formoterol Turbuhaler 9 microg b.i.d. and inhaled steroids. The study. performed at three centres (Goteborg and Lund, Sweden, and Trondheim, Norway), consisted of an open-label part with formoterol Turbuhaler 9 microg b.i.d. and a randomized, double-blind, cross-over part with a single dose (on top of the regular treatment) of either formoterol Turbuhaler 9 microg, terbutaline Turbuhaler 0.5 mg or placebo Turbuhaler. The patients attended the clinic six times: twice for screening visits, three times for randomized treatment and once for a follow-up visit. Patients received regular b.i.d. treatment with formoterol 9 microg for a mean period of 16 days. Formoterol gave a post-exercise fall of 12, 10, 15 and 17% in forced expiratory volume in 1 sec (FEV1) 15 min, 4, 8 and 12 h after inhalation. The differences compared with placebo (falls of 26, 22, 23 and 22%) and terbutaline (falls of 17, 18, 22 and 22%) were all statistically significant (P<0.05 for all comparisons). Patients on regular treatment with formoterol Turbuhaler 9 microg b.i.d. have a significant protection against EIB up to 12 h after inhalation of formoterol 9 microg. The protection was also significantly better than that of terbutaline Turbuhaler 0.5 mg.}},
author = {{Vilsvik, J and Ankerst, Jaro and Palmqvist, M and Persson, G and Schaanning, J and Schwabe, G and Johansson, A}},
issn = {{1532-3064}},
keywords = {{formoterol turbuhaler®; asthma; exercise; cold air.}},
language = {{eng}},
number = {{6}},
pages = {{484--490}},
publisher = {{Elsevier}},
series = {{Respiratory Medicine}},
title = {{Protection against cold air and exercise-induced bronchoconstriction while on regular treatment with Oxis}},
url = {{http://dx.doi.org/10.1053/rmed.2001.1074}},
doi = {{10.1053/rmed.2001.1074}},
volume = {{95}},
year = {{2001}},
}