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Alzheimer's disease and the cerebellum: a morphologic study on neuronal and glial changes

Sjöbeck, Martin LU and Englund, Elisabet LU (2001) In Dementia and Geriatric Cognitive Disorders 12(3). p.211-218
Abstract
Structural manifestations of Alzheimer's disease (AD) including neuronal loss were investigated in 12 cases of AD and in 10 healthy age-matched controls, with focus on the cerebellum. Linear Purkinje cell (PC) density was measured in the vermis and cerebellar hemispheres. Neurons were also counted in the inferior olivary nucleus. In vermis of the AD cases, the mean PC number was significantly lower (p = 0.019) than in the controls. The neurons in the inferior olive were similarly fewer, though not significantly (p = 0.13). Molecular layer gliosis and atrophy in the vermis was clearly severer in AD than in the controls. Features typical of cerebral Alzheimer encephalopathy (plaques, tangles and microvacuolization) were inconspicious. The... (More)
Structural manifestations of Alzheimer's disease (AD) including neuronal loss were investigated in 12 cases of AD and in 10 healthy age-matched controls, with focus on the cerebellum. Linear Purkinje cell (PC) density was measured in the vermis and cerebellar hemispheres. Neurons were also counted in the inferior olivary nucleus. In vermis of the AD cases, the mean PC number was significantly lower (p = 0.019) than in the controls. The neurons in the inferior olive were similarly fewer, though not significantly (p = 0.13). Molecular layer gliosis and atrophy in the vermis was clearly severer in AD than in the controls. Features typical of cerebral Alzheimer encephalopathy (plaques, tangles and microvacuolization) were inconspicious. The structural cerebellar changes in the AD cases were thus neuronal loss, atrophy and gliosis, judged to represent the disease process, and with a main involvement in the vermis. This may be reflected in some of the symptoms and signs seen in AD, signs that are generally overlooked or judged to be of noncerebellar origin. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cerebellum, Alzheimer's disease, Purkinje cells, Neuronal counting, Inferior olivary nucleus, Gliosis, Atrophy
in
Dementia and Geriatric Cognitive Disorders
volume
12
issue
3
pages
211 - 218
publisher
Karger
external identifiers
  • pmid:11244215
  • scopus:0035106551
ISSN
1420-8008
DOI
10.1159/000051260
language
English
LU publication?
yes
id
b9e67269-b1c7-46de-92b5-df1ab9aafa6d (old id 1121936)
date added to LUP
2008-07-15 08:23:52
date last changed
2018-06-24 03:43:24
@article{b9e67269-b1c7-46de-92b5-df1ab9aafa6d,
  abstract     = {Structural manifestations of Alzheimer's disease (AD) including neuronal loss were investigated in 12 cases of AD and in 10 healthy age-matched controls, with focus on the cerebellum. Linear Purkinje cell (PC) density was measured in the vermis and cerebellar hemispheres. Neurons were also counted in the inferior olivary nucleus. In vermis of the AD cases, the mean PC number was significantly lower (p = 0.019) than in the controls. The neurons in the inferior olive were similarly fewer, though not significantly (p = 0.13). Molecular layer gliosis and atrophy in the vermis was clearly severer in AD than in the controls. Features typical of cerebral Alzheimer encephalopathy (plaques, tangles and microvacuolization) were inconspicious. The structural cerebellar changes in the AD cases were thus neuronal loss, atrophy and gliosis, judged to represent the disease process, and with a main involvement in the vermis. This may be reflected in some of the symptoms and signs seen in AD, signs that are generally overlooked or judged to be of noncerebellar origin.},
  author       = {Sjöbeck, Martin and Englund, Elisabet},
  issn         = {1420-8008},
  keyword      = {Cerebellum,Alzheimer's disease,Purkinje cells,Neuronal counting,Inferior olivary nucleus,Gliosis,Atrophy},
  language     = {eng},
  number       = {3},
  pages        = {211--218},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Alzheimer's disease and the cerebellum: a morphologic study on neuronal and glial changes},
  url          = {http://dx.doi.org/10.1159/000051260},
  volume       = {12},
  year         = {2001},
}