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Dispersion of atrial repolarization in patients with paroxysmal atrial fibrillation

Li, Z ; Hertervig, Eva LU ; Yuan, Shiwen LU ; Yang, Y ; Lin, Z and Olsson, Bertil LU (2001) In Europace 3(4). p.285-291
Abstract
To study the role of the dispersion of atrial repolarization (DAR) in the genesis of atrial fibrillation (AF), monophasic action potentials (MAP) were recorded simultaneously from a catheter at the high lateral right atrium (HLRA) and a catheter moving around the high, middle and low lateral right atrium (RA) the high, anterior and posterior septal RA and the RA appendage in 15 patients with paroxysmal AF and 15 patients with atrioventricular nodal re-entry tachycardia (AVNRT) or concealed Wolff-Parkinson-White syndrome (WPW) without history of AF. After recordings during sinus rhythm (SR), MAPs were recorded during programmed stimulation (PS) via the HLRA catheter at a drive cycle length (CL) of 500 ms. Thus, MAPs were recorded... (More)
To study the role of the dispersion of atrial repolarization (DAR) in the genesis of atrial fibrillation (AF), monophasic action potentials (MAP) were recorded simultaneously from a catheter at the high lateral right atrium (HLRA) and a catheter moving around the high, middle and low lateral right atrium (RA) the high, anterior and posterior septal RA and the RA appendage in 15 patients with paroxysmal AF and 15 patients with atrioventricular nodal re-entry tachycardia (AVNRT) or concealed Wolff-Parkinson-White syndrome (WPW) without history of AF. After recordings during sinus rhythm (SR), MAPs were recorded during programmed stimulation (PS) via the HLRA catheter at a drive cycle length (CL) of 500 ms. Thus, MAPs were recorded simultaneously from 2 sites at a time and sequentially from 4 to 12 sites during SR, drive pacing and PS. Taking the MAP at the HLRA as reference, the dispersion of repolarization time (dispersion of RT) and its two components, the dispersions of activation time (dispersion of AT) and MAP duration (dispersion of MAP duration) among the 4 to 12 sites were calculated and taken as parameters of DAR. RESULTS: During SR and PS, the maximal dispersion of RT was significantly greater in AF than in control patients, 113+/-49 ms vs 50+/-28 ms (P<0.001) and 114+/-56 vs 70+/-43 ms (P<0.05) respectively. The increased dispersion of RT in the AF group was caused by increases in both dispersion of MAP duration and dispersion of AT. CONCLUSION: During SR and PS, DAR increased in patients with paroxysmal AF due to increases in dispersion of MAP duration and dispersion of AT, which suggests the involvement of both repolarization and conduction disturbances in the development of paroxysmal AF. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Monophasic action potential, atrial fibrillation, repolarization, dispersion
in
Europace
volume
3
issue
4
pages
285 - 291
publisher
Oxford University Press
external identifiers
  • pmid:11678386
  • scopus:0034779255
ISSN
1532-2092
DOI
10.1053/eupc.2001.0183
language
English
LU publication?
yes
id
2cfc2b75-9b7a-4b26-8adc-77da7e3071d4 (old id 1122369)
date added to LUP
2016-04-01 12:35:25
date last changed
2022-01-27 07:11:47
@article{2cfc2b75-9b7a-4b26-8adc-77da7e3071d4,
  abstract     = {{To study the role of the dispersion of atrial repolarization (DAR) in the genesis of atrial fibrillation (AF), monophasic action potentials (MAP) were recorded simultaneously from a catheter at the high lateral right atrium (HLRA) and a catheter moving around the high, middle and low lateral right atrium (RA) the high, anterior and posterior septal RA and the RA appendage in 15 patients with paroxysmal AF and 15 patients with atrioventricular nodal re-entry tachycardia (AVNRT) or concealed Wolff-Parkinson-White syndrome (WPW) without history of AF. After recordings during sinus rhythm (SR), MAPs were recorded during programmed stimulation (PS) via the HLRA catheter at a drive cycle length (CL) of 500 ms. Thus, MAPs were recorded simultaneously from 2 sites at a time and sequentially from 4 to 12 sites during SR, drive pacing and PS. Taking the MAP at the HLRA as reference, the dispersion of repolarization time (dispersion of RT) and its two components, the dispersions of activation time (dispersion of AT) and MAP duration (dispersion of MAP duration) among the 4 to 12 sites were calculated and taken as parameters of DAR. RESULTS: During SR and PS, the maximal dispersion of RT was significantly greater in AF than in control patients, 113+/-49 ms vs 50+/-28 ms (P&lt;0.001) and 114+/-56 vs 70+/-43 ms (P&lt;0.05) respectively. The increased dispersion of RT in the AF group was caused by increases in both dispersion of MAP duration and dispersion of AT. CONCLUSION: During SR and PS, DAR increased in patients with paroxysmal AF due to increases in dispersion of MAP duration and dispersion of AT, which suggests the involvement of both repolarization and conduction disturbances in the development of paroxysmal AF.}},
  author       = {{Li, Z and Hertervig, Eva and Yuan, Shiwen and Yang, Y and Lin, Z and Olsson, Bertil}},
  issn         = {{1532-2092}},
  keywords     = {{Monophasic action potential; atrial fibrillation; repolarization; dispersion}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{285--291}},
  publisher    = {{Oxford University Press}},
  series       = {{Europace}},
  title        = {{Dispersion of atrial repolarization in patients with paroxysmal atrial fibrillation}},
  url          = {{http://dx.doi.org/10.1053/eupc.2001.0183}},
  doi          = {{10.1053/eupc.2001.0183}},
  volume       = {{3}},
  year         = {{2001}},
}