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A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11

Parker, Alex; Meyer, Joanne; Lewitzky, Steve; Rennich, Jean S.; Chan, Gayun; Thomas, Jeffrey D.; Orho-Melander, Marju LU ; Lehtovirta, Mikko; Forsblom, Carol and Hyrkko, Auli, et al. (2001) In Diabetes 50(3). p.675-680
Abstract
Genome-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2 diabetes revealed linkage to a previously unreported susceptibility locus on chromosome 18p11. This result improved with stringent subphenotyping using age- and sex-adjusted BMI, ultimately reaching a logarithm of odds of 3.82 (allele sharing 0.6654) at a point between markers D18S976 and D18S391 when the most obese 20% of the sample was analyzed. Several genes on chromosome 18 have been suggested as metabolic disease candidates, but none of these colocalize with our linkage result. We conclude that our results provide support for the presence of a currently uncharacterized gene on chromosome 18p, certain alleles of which confer increased susceptibility to... (More)
Genome-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2 diabetes revealed linkage to a previously unreported susceptibility locus on chromosome 18p11. This result improved with stringent subphenotyping using age- and sex-adjusted BMI, ultimately reaching a logarithm of odds of 3.82 (allele sharing 0.6654) at a point between markers D18S976 and D18S391 when the most obese 20% of the sample was analyzed. Several genes on chromosome 18 have been suggested as metabolic disease candidates, but none of these colocalize with our linkage result. We conclude that our results provide support for the presence of a currently uncharacterized gene on chromosome 18p, certain alleles of which confer increased susceptibility to type 2 diabetes in conjunction with obesity. We additionally observed moderate evidence for linkage to chromosome 1, near marker D1S3462; chromosome 4, near marker D4S2361; chromosome 5, near marker D5S1505; and chromosome 17, near marker D17S1301. (Less)
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type
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publication status
published
subject
in
Diabetes
volume
50
issue
3
pages
675 - 680
publisher
American Diabetes Association Inc.
external identifiers
  • pmid:11246890
  • scopus:0035120347
ISSN
1939-327X
DOI
10.2337/diabetes.50.3.675
language
English
LU publication?
yes
id
33da6598-8036-4f0d-aefa-54a93db3e4de (old id 1122560)
date added to LUP
2008-07-09 10:40:34
date last changed
2018-03-18 04:36:13
@article{33da6598-8036-4f0d-aefa-54a93db3e4de,
  abstract     = {Genome-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2 diabetes revealed linkage to a previously unreported susceptibility locus on chromosome 18p11. This result improved with stringent subphenotyping using age- and sex-adjusted BMI, ultimately reaching a logarithm of odds of 3.82 (allele sharing 0.6654) at a point between markers D18S976 and D18S391 when the most obese 20% of the sample was analyzed. Several genes on chromosome 18 have been suggested as metabolic disease candidates, but none of these colocalize with our linkage result. We conclude that our results provide support for the presence of a currently uncharacterized gene on chromosome 18p, certain alleles of which confer increased susceptibility to type 2 diabetes in conjunction with obesity. We additionally observed moderate evidence for linkage to chromosome 1, near marker D1S3462; chromosome 4, near marker D4S2361; chromosome 5, near marker D5S1505; and chromosome 17, near marker D17S1301.},
  author       = {Parker, Alex and Meyer, Joanne and Lewitzky, Steve and Rennich, Jean S. and Chan, Gayun and Thomas, Jeffrey D. and Orho-Melander, Marju and Lehtovirta, Mikko and Forsblom, Carol and Hyrkko, Auli and Carlsson, Martin and Lindgren, Cecilia and Groop, Leif},
  issn         = {1939-327X},
  language     = {eng},
  number       = {3},
  pages        = {675--680},
  publisher    = {American Diabetes Association Inc.},
  series       = {Diabetes},
  title        = {A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11},
  url          = {http://dx.doi.org/10.2337/diabetes.50.3.675},
  volume       = {50},
  year         = {2001},
}