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The impact of factor V mutation on the risk for occlusion in patients undergoing peripheral vascular reconstructions

Sampram, E S and Lindblad, Bengt LU (2001) In European Journal of Vascular and Endovascular Surgery 22(2). p.134-138
Abstract
OBJECTIVE: to determine the impact of Factor V-Leiden on the patency of peripheral vascular reconstructions. DESIGN: prospective, open and consecutive study. METHODS: a total of 775 patients, who were electively admitted between 1995 and 1997 to the vascular ward unit, were prospectively analysed for frequency of Factor V-Leiden mutation and patency of reconstruction (one month and one year). The patients were grouped into carotid, abdominal aortic aneurysm (AAA), renal artery, aortoiliac, infrainguinal, and venous categories according to procedures and anatomical sites. Post-reconstruction complications and associated risk factors were also analysed. RESULT: in infrainguinal patients Factor V-Leiden was seen in 16% of the patients... (More)
OBJECTIVE: to determine the impact of Factor V-Leiden on the patency of peripheral vascular reconstructions. DESIGN: prospective, open and consecutive study. METHODS: a total of 775 patients, who were electively admitted between 1995 and 1997 to the vascular ward unit, were prospectively analysed for frequency of Factor V-Leiden mutation and patency of reconstruction (one month and one year). The patients were grouped into carotid, abdominal aortic aneurysm (AAA), renal artery, aortoiliac, infrainguinal, and venous categories according to procedures and anatomical sites. Post-reconstruction complications and associated risk factors were also analysed. RESULT: in infrainguinal patients Factor V-Leiden was seen in 16% of the patients compared with 10% in the controls. (Odds ratio 1.60, CI 0.91-2.81). Hypertension, pulmonary disease and smoking were more frequent in individuals without Factor V-Leiden. Analysing all 775 reconstructions, occlusions were more frequent at one month (14% vs 12%) (p=0.02) in patients with Factor V-Leiden compared with patients without the mutation. Though this trend was also noted few patients having infrainguinal reconstructions, the difference was not significant (37% vs 22% (p=0.15) and 46% vs 27% (p=0.09) after 1 and 12 months, respectively). CONCLUSION: factor V mutation (Factor V-Leiden) was more frequent in patients having occluded vascular reconstructions. Further evaluation is needed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Factor V-Leiden, Occlusion, Peripheral vascular reconstruction
in
European Journal of Vascular and Endovascular Surgery
volume
22
issue
2
pages
134 - 138
publisher
Elsevier
external identifiers
  • pmid:11472046
  • scopus:0034909305
ISSN
1532-2165
DOI
10.1053/ejvs.2001.1420
language
English
LU publication?
yes
id
b0996b53-4e93-4c38-ab6d-3b466cc70933 (old id 1122572)
alternative location
http://www.sciencedirect.com/science/article/pii/S1078588401914200
http://www.ncbi.nlm.nih.gov/pubmed/11472046
date added to LUP
2008-07-14 09:29:54
date last changed
2018-01-07 09:19:05
@article{b0996b53-4e93-4c38-ab6d-3b466cc70933,
  abstract     = {OBJECTIVE: to determine the impact of Factor V-Leiden on the patency of peripheral vascular reconstructions. DESIGN: prospective, open and consecutive study. METHODS: a total of 775 patients, who were electively admitted between 1995 and 1997 to the vascular ward unit, were prospectively analysed for frequency of Factor V-Leiden mutation and patency of reconstruction (one month and one year). The patients were grouped into carotid, abdominal aortic aneurysm (AAA), renal artery, aortoiliac, infrainguinal, and venous categories according to procedures and anatomical sites. Post-reconstruction complications and associated risk factors were also analysed. RESULT: in infrainguinal patients Factor V-Leiden was seen in 16% of the patients compared with 10% in the controls. (Odds ratio 1.60, CI 0.91-2.81). Hypertension, pulmonary disease and smoking were more frequent in individuals without Factor V-Leiden. Analysing all 775 reconstructions, occlusions were more frequent at one month (14% vs 12%) (p=0.02) in patients with Factor V-Leiden compared with patients without the mutation. Though this trend was also noted few patients having infrainguinal reconstructions, the difference was not significant (37% vs 22% (p=0.15) and 46% vs 27% (p=0.09) after 1 and 12 months, respectively). CONCLUSION: factor V mutation (Factor V-Leiden) was more frequent in patients having occluded vascular reconstructions. Further evaluation is needed.},
  author       = {Sampram, E S and Lindblad, Bengt},
  issn         = {1532-2165},
  keyword      = {Factor V-Leiden,Occlusion,Peripheral vascular reconstruction},
  language     = {eng},
  number       = {2},
  pages        = {134--138},
  publisher    = {Elsevier},
  series       = {European Journal of Vascular and Endovascular Surgery},
  title        = {The impact of factor V mutation on the risk for occlusion in patients undergoing peripheral vascular reconstructions},
  url          = {http://dx.doi.org/10.1053/ejvs.2001.1420},
  volume       = {22},
  year         = {2001},
}