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Alveolar albumin leakage during large tidal volume ventilation and surfactant dysfunction

Liu, Jin-Ming; Evander, Eva LU ; Zhao, Jiang; Wollmer, Per LU and Jonson, Björn LU (2001) In Clinical Physiology 21(4). p.421-427
Abstract
Detergent given as an aerosol and large tidal volume ventilation (LTVV) have been observed, by us, to promote lung injury by an additive effect on alveolocapillary barrier function. The surfactant system may be further damaged if protein leakage occurs into the alveoli. The aim was to study the effect of detergent and LTVV on the alveolar leakage of albumin and also the effect of detergent on surface activity of lung washings and lung tissue extracts. Technetium-99m-labelled human serum albumin was given intravenously. The alveolar leakage of albumin was measured after perturbing the surfactant system with the detergent dioctyl sodium sulfosuccinate either singly or in combination with LTVV. Four groups of rabbits were studied after 3 h of... (More)
Detergent given as an aerosol and large tidal volume ventilation (LTVV) have been observed, by us, to promote lung injury by an additive effect on alveolocapillary barrier function. The surfactant system may be further damaged if protein leakage occurs into the alveoli. The aim was to study the effect of detergent and LTVV on the alveolar leakage of albumin and also the effect of detergent on surface activity of lung washings and lung tissue extracts. Technetium-99m-labelled human serum albumin was given intravenously. The alveolar leakage of albumin was measured after perturbing the surfactant system with the detergent dioctyl sodium sulfosuccinate either singly or in combination with LTVV. Four groups of rabbits were studied after 3 h of experimental ventilation. Surface tension measurements of tissue extracts, lung mechanics and gas exchange did not show any differences between groups. Wet lung weight and albumin leakage were significantly increased in the two groups subjected to LTVV compared with groups given normal tidal volume ventilation. Low doses of detergent did not affect surface activity of lung tissue extracts or alveolar leakage of albumin. LTVV increased alveolar leakage of albumin and produced oedema. No additive effect was seen when detergent and LTVV were combined. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Physiology
volume
21
issue
4
pages
421 - 427
publisher
Wiley Online Library
external identifiers
  • pmid:11442575
  • scopus:0034962979
ISSN
1365-2281
DOI
10.1046/j.1365-2281.2001.00348.x
language
English
LU publication?
yes
id
0a7d0335-cd29-447b-88a0-99435431965b (old id 1122781)
date added to LUP
2008-07-03 14:13:30
date last changed
2018-05-29 11:01:21
@article{0a7d0335-cd29-447b-88a0-99435431965b,
  abstract     = {Detergent given as an aerosol and large tidal volume ventilation (LTVV) have been observed, by us, to promote lung injury by an additive effect on alveolocapillary barrier function. The surfactant system may be further damaged if protein leakage occurs into the alveoli. The aim was to study the effect of detergent and LTVV on the alveolar leakage of albumin and also the effect of detergent on surface activity of lung washings and lung tissue extracts. Technetium-99m-labelled human serum albumin was given intravenously. The alveolar leakage of albumin was measured after perturbing the surfactant system with the detergent dioctyl sodium sulfosuccinate either singly or in combination with LTVV. Four groups of rabbits were studied after 3 h of experimental ventilation. Surface tension measurements of tissue extracts, lung mechanics and gas exchange did not show any differences between groups. Wet lung weight and albumin leakage were significantly increased in the two groups subjected to LTVV compared with groups given normal tidal volume ventilation. Low doses of detergent did not affect surface activity of lung tissue extracts or alveolar leakage of albumin. LTVV increased alveolar leakage of albumin and produced oedema. No additive effect was seen when detergent and LTVV were combined.},
  author       = {Liu, Jin-Ming and Evander, Eva and Zhao, Jiang and Wollmer, Per and Jonson, Björn},
  issn         = {1365-2281},
  language     = {eng},
  number       = {4},
  pages        = {421--427},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology},
  title        = {Alveolar albumin leakage during large tidal volume ventilation and surfactant dysfunction},
  url          = {http://dx.doi.org/10.1046/j.1365-2281.2001.00348.x},
  volume       = {21},
  year         = {2001},
}