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Elastic properties of the lung and the chest wall in young and adult healthy pigs

De Robertis, E; Liu, J M; Blomquist, Sten LU ; Dahm, Peter LU ; Thörne, Johan LU and Jonson, Björn LU (2001) In European Respiratory Journal1988-01-01+01:00 17(4). p.703-711
Abstract
Understanding of the elastic pressure/volume (Pel/V) curve is still limited in health and disease. The aim of the present study was to elucidate the Pel/V curve and elastance of the respiratory system (ERS) lung (EL) and chest wall (ECW) in healthy pigs. Six young (20.8 kg) and seven adult (58.9 kg), anaesthetized, paralysed and ventilated pigs were studied. Pel/V curves were recorded at zero end-expiratory pressure (ZEEP) and at positive end-expiratory pressure (PEEP) up to 40 cmH2O with a computer controlled ventilator during an insufflation at a low, constant flow. Pel/V curves of the respiratory system showed a complex pattern in both young and adult pigs. During the insufflation, ERS decreased, increased, fell, and increased again. A... (More)
Understanding of the elastic pressure/volume (Pel/V) curve is still limited in health and disease. The aim of the present study was to elucidate the Pel/V curve and elastance of the respiratory system (ERS) lung (EL) and chest wall (ECW) in healthy pigs. Six young (20.8 kg) and seven adult (58.9 kg), anaesthetized, paralysed and ventilated pigs were studied. Pel/V curves were recorded at zero end-expiratory pressure (ZEEP) and at positive end-expiratory pressure (PEEP) up to 40 cmH2O with a computer controlled ventilator during an insufflation at a low, constant flow. Pel/V curves of the respiratory system showed a complex pattern in both young and adult pigs. During the insufflation, ERS decreased, increased, fell, and increased again. A second Pel/V curve recorded immediately after the first one showed lower elastance and only one early fall in ERS. ECW fell over the initial segment and was then nearly stable. Difference between 1st and 2nd curves reflected changes in EL caused by recruitment during the 1st insufflation. At PEEP, such signs of collapse and recruitment were reduced. A strong tendency to lung collapse contributes to a complex pattern of elastic pressure/volume curves. At low volumes and distending pressures the chest wall contributes significantly to changes in respiratory system elastance. (Less)
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author
organization
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type
Contribution to journal
publication status
published
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in
European Respiratory Journal1988-01-01+01:00
volume
17
issue
4
pages
703 - 711
publisher
Eur Respiratory Soc
external identifiers
  • pmid:11401067
  • scopus:0035000686
ISSN
1399-3003
language
English
LU publication?
yes
id
bd1d5d91-3024-4246-96e3-e86c2a1a398b (old id 1122785)
alternative location
http://erj.ersjournals.com/content/17/4/703.full
date added to LUP
2008-06-26 11:58:59
date last changed
2018-01-07 06:20:10
@article{bd1d5d91-3024-4246-96e3-e86c2a1a398b,
  abstract     = {Understanding of the elastic pressure/volume (Pel/V) curve is still limited in health and disease. The aim of the present study was to elucidate the Pel/V curve and elastance of the respiratory system (ERS) lung (EL) and chest wall (ECW) in healthy pigs. Six young (20.8 kg) and seven adult (58.9 kg), anaesthetized, paralysed and ventilated pigs were studied. Pel/V curves were recorded at zero end-expiratory pressure (ZEEP) and at positive end-expiratory pressure (PEEP) up to 40 cmH2O with a computer controlled ventilator during an insufflation at a low, constant flow. Pel/V curves of the respiratory system showed a complex pattern in both young and adult pigs. During the insufflation, ERS decreased, increased, fell, and increased again. A second Pel/V curve recorded immediately after the first one showed lower elastance and only one early fall in ERS. ECW fell over the initial segment and was then nearly stable. Difference between 1st and 2nd curves reflected changes in EL caused by recruitment during the 1st insufflation. At PEEP, such signs of collapse and recruitment were reduced. A strong tendency to lung collapse contributes to a complex pattern of elastic pressure/volume curves. At low volumes and distending pressures the chest wall contributes significantly to changes in respiratory system elastance.},
  author       = {De Robertis, E and Liu, J M and Blomquist, Sten and Dahm, Peter and Thörne, Johan and Jonson, Björn},
  issn         = {1399-3003},
  language     = {eng},
  number       = {4},
  pages        = {703--711},
  publisher    = {Eur Respiratory Soc},
  series       = {European Respiratory Journal1988-01-01+01:00},
  title        = {Elastic properties of the lung and the chest wall in young and adult healthy pigs},
  volume       = {17},
  year         = {2001},
}