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Urate and arteriosclerosis in primary hyperparathyroidism

Westerdahl, Johan LU ; Valdemarsson, Stig LU ; Lindblom, Pia LU and Bergenfelz, Anders LU (2001) In Clinical Endocrinology 54(6). p.805-811
Abstract
OBJECTIVE: An increased mortality due to cardiovascular disease has been reported in patients with primary hyperparathyroidism (pHPT). An association between urate and cardiovascular disease has been suggested. Metabolic abnormalities in pHPT may include urate. We therefore evaluated the metabolic arteriosclerotic risk profile in pHPT with special focus on the role of urate. DESIGN: Retrospective analysis of data before and 1 year after surgery for pHPT. PATIENTS: 130 consecutive patients, over the age of 44 years, who underwent surgery for pHPT. MEASUREMENTS: Biochemical variables known to reflect risk of arteriosclerotic disease (AD) and renal function tests including measurement of glomerular filtration rate (GFR) were investigated... (More)
OBJECTIVE: An increased mortality due to cardiovascular disease has been reported in patients with primary hyperparathyroidism (pHPT). An association between urate and cardiovascular disease has been suggested. Metabolic abnormalities in pHPT may include urate. We therefore evaluated the metabolic arteriosclerotic risk profile in pHPT with special focus on the role of urate. DESIGN: Retrospective analysis of data before and 1 year after surgery for pHPT. PATIENTS: 130 consecutive patients, over the age of 44 years, who underwent surgery for pHPT. MEASUREMENTS: Biochemical variables known to reflect risk of arteriosclerotic disease (AD) and renal function tests including measurement of glomerular filtration rate (GFR) were investigated before and 1 year after surgery. RESULTS: pHPT patients with AD (n = 40) were older and had higher serum levels of urate and triglyceride, and more impaired renal function in comparison with patients without AD. PTH and calcium values did not differ. Multiple logistic regression analysis indicated that urate was an independent risk factor for AD in pHPT (P < 0.01). Three variables were shown to be positively associated with urate; male gender (P < 0.01), fasting blood glucose (P < 0.05) and serum level of triglyceride (P < 0.05). CONCLUSIONS: Urate was found to be an independent risk factor for arteriosclerotic disease in primary hyperparathyroidism. Serum level of urate could (in addition to gender) be associated with a metabolic disorder comprising increased glucose and triglyceride levels. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Endocrinology
volume
54
issue
6
pages
805 - 811
publisher
Wiley-Blackwell
external identifiers
  • pmid:11422116
  • scopus:0035725547
ISSN
1365-2265
DOI
10.1046/j.1365-2265.2001.01265.x
language
English
LU publication?
yes
id
b805128d-32b7-4e7a-acdd-1346ea151d83 (old id 1122829)
date added to LUP
2016-04-01 11:52:48
date last changed
2022-01-26 19:37:10
@article{b805128d-32b7-4e7a-acdd-1346ea151d83,
  abstract     = {{OBJECTIVE: An increased mortality due to cardiovascular disease has been reported in patients with primary hyperparathyroidism (pHPT). An association between urate and cardiovascular disease has been suggested. Metabolic abnormalities in pHPT may include urate. We therefore evaluated the metabolic arteriosclerotic risk profile in pHPT with special focus on the role of urate. DESIGN: Retrospective analysis of data before and 1 year after surgery for pHPT. PATIENTS: 130 consecutive patients, over the age of 44 years, who underwent surgery for pHPT. MEASUREMENTS: Biochemical variables known to reflect risk of arteriosclerotic disease (AD) and renal function tests including measurement of glomerular filtration rate (GFR) were investigated before and 1 year after surgery. RESULTS: pHPT patients with AD (n = 40) were older and had higher serum levels of urate and triglyceride, and more impaired renal function in comparison with patients without AD. PTH and calcium values did not differ. Multiple logistic regression analysis indicated that urate was an independent risk factor for AD in pHPT (P &lt; 0.01). Three variables were shown to be positively associated with urate; male gender (P &lt; 0.01), fasting blood glucose (P &lt; 0.05) and serum level of triglyceride (P &lt; 0.05). CONCLUSIONS: Urate was found to be an independent risk factor for arteriosclerotic disease in primary hyperparathyroidism. Serum level of urate could (in addition to gender) be associated with a metabolic disorder comprising increased glucose and triglyceride levels.}},
  author       = {{Westerdahl, Johan and Valdemarsson, Stig and Lindblom, Pia and Bergenfelz, Anders}},
  issn         = {{1365-2265}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{805--811}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Clinical Endocrinology}},
  title        = {{Urate and arteriosclerosis in primary hyperparathyroidism}},
  url          = {{http://dx.doi.org/10.1046/j.1365-2265.2001.01265.x}},
  doi          = {{10.1046/j.1365-2265.2001.01265.x}},
  volume       = {{54}},
  year         = {{2001}},
}