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Chlamydia trachomatis infections--a major concern for reproductive health. Where do we stand regarding epidemiology, pathogenesis, diagnosis and therapy?

Mårdh, Per-Anders LU and Novikova, N (2001) In European Journal of Contraception & Reproductive Health Care 6(2). p.115-126
Abstract
The current article deals with the problem of distinguishing between relapse and reinfection of genital chlamydial infections due to the chronic character of such infections. The problem of detecting and treating chlamydial pelvic inflammatory disease is considered. Factors that may affect the clinical presentation of such infections, such as hormonal therapy, are also highlighted. Observations on novel manifestations of Chlamydia trachomatis infections, such as spontaneous abortion, prematurity and intrauterine infections as well as a statistical correlation of a certain serovar to cervical cancer, are described. The representivity of the data on infections with C. trachomatis monitored in national surveillance programs is questioned. The... (More)
The current article deals with the problem of distinguishing between relapse and reinfection of genital chlamydial infections due to the chronic character of such infections. The problem of detecting and treating chlamydial pelvic inflammatory disease is considered. Factors that may affect the clinical presentation of such infections, such as hormonal therapy, are also highlighted. Observations on novel manifestations of Chlamydia trachomatis infections, such as spontaneous abortion, prematurity and intrauterine infections as well as a statistical correlation of a certain serovar to cervical cancer, are described. The representivity of the data on infections with C. trachomatis monitored in national surveillance programs is questioned. The paper also elaborates on which type of sample, sample site and detection method may be optimal for the diagnosis of such infections in women. Whether to screen at clinics and self-sampling at home of specimens from an index case and a sexual partner to be mailed to a laboratory for testing is discussed. Whether or not females are more susceptible to genital chlamydial infections and their sequelae than males is also discussed. The effectiveness of recommended antibiotic regimens is considered, e.g. in relation to the recent detection of the existence of strains of C. trachomatis that show heterotypic resistance to drugs commonly used for their treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CHLAMYDIA TRACHOMATIS, GENITAL INFECTIONS, PREGNANCY, DIAGNOSIS, THERAPY
in
European Journal of Contraception & Reproductive Health Care
volume
6
issue
2
pages
115 - 126
publisher
Parthenon Publishing
external identifiers
  • pmid:11518449
  • scopus:0034897052
ISSN
1362-5187
DOI
10.1080/713604211
language
English
LU publication?
yes
id
3801e340-2641-455c-af8a-9fa0d50c8751 (old id 1122833)
date added to LUP
2008-07-04 14:47:31
date last changed
2018-05-29 10:57:15
@article{3801e340-2641-455c-af8a-9fa0d50c8751,
  abstract     = {The current article deals with the problem of distinguishing between relapse and reinfection of genital chlamydial infections due to the chronic character of such infections. The problem of detecting and treating chlamydial pelvic inflammatory disease is considered. Factors that may affect the clinical presentation of such infections, such as hormonal therapy, are also highlighted. Observations on novel manifestations of Chlamydia trachomatis infections, such as spontaneous abortion, prematurity and intrauterine infections as well as a statistical correlation of a certain serovar to cervical cancer, are described. The representivity of the data on infections with C. trachomatis monitored in national surveillance programs is questioned. The paper also elaborates on which type of sample, sample site and detection method may be optimal for the diagnosis of such infections in women. Whether to screen at clinics and self-sampling at home of specimens from an index case and a sexual partner to be mailed to a laboratory for testing is discussed. Whether or not females are more susceptible to genital chlamydial infections and their sequelae than males is also discussed. The effectiveness of recommended antibiotic regimens is considered, e.g. in relation to the recent detection of the existence of strains of C. trachomatis that show heterotypic resistance to drugs commonly used for their treatment.},
  author       = {Mårdh, Per-Anders and Novikova, N},
  issn         = {1362-5187},
  keyword      = {CHLAMYDIA TRACHOMATIS,GENITAL INFECTIONS,PREGNANCY,DIAGNOSIS,THERAPY},
  language     = {eng},
  number       = {2},
  pages        = {115--126},
  publisher    = {Parthenon Publishing},
  series       = {European Journal of Contraception & Reproductive Health Care},
  title        = {Chlamydia trachomatis infections--a major concern for reproductive health. Where do we stand regarding epidemiology, pathogenesis, diagnosis and therapy?},
  url          = {http://dx.doi.org/10.1080/713604211},
  volume       = {6},
  year         = {2001},
}