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Ventriculo-vascular interaction in the normal development of the fetal circulation

Gardiner, Helena; Brodszki, Jana LU ; Eriksson, Anders; Stale, Håkan LU and Marsal, Karel LU (2001) In Early Human Development 65(2). p.97-106
Abstract
OBJECTIVES: To examine cardiovascular physiology in the healthy fetus during normal development. DESIGN: Twenty normal fetuses were studied longitudinally from 20 weeks to term. Serial echocardiography was performed, and arterial and venous diameter pulse wave characteristics and aortic pulse wave propagation velocity (PWV) were examined in the thoracic descending aorta (AoD) and inferior caval vein (IVC) using an ultrasonic phase-locked echo-tracking system. Statistical analyses included ANOVA, paired t-test and logistic regression where appropriate. RESULTS: Aortic PWV, maximum incremental and late decremental velocities increased with gestation while the relative pulse amplitude decreased, reflecting falling distal impedance. There was... (More)
OBJECTIVES: To examine cardiovascular physiology in the healthy fetus during normal development. DESIGN: Twenty normal fetuses were studied longitudinally from 20 weeks to term. Serial echocardiography was performed, and arterial and venous diameter pulse wave characteristics and aortic pulse wave propagation velocity (PWV) were examined in the thoracic descending aorta (AoD) and inferior caval vein (IVC) using an ultrasonic phase-locked echo-tracking system. Statistical analyses included ANOVA, paired t-test and logistic regression where appropriate. RESULTS: Aortic PWV, maximum incremental and late decremental velocities increased with gestation while the relative pulse amplitude decreased, reflecting falling distal impedance. There was a linear increase in cardiac preload and relative pulse amplitude in the IVC with gestation that correlated significantly with the presence of end-diastolic flow in the pulmonary artery and improvement in right ventricular diastolic function. CONCLUSIONS: Non-invasive concurrent assessment of preload, ventricular function and impedance are possible in the fetus and may prove useful in the longitudinal study of fetal adaptation to pathophysiological changes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fetus, Ultrasound, Vascular physiology, Echo-tracking, Pulse wave velocity
in
Early Human Development
volume
65
issue
2
pages
97 - 106
publisher
Elsevier
external identifiers
  • pmid:11641031
  • scopus:0034788841
ISSN
1872-6232
DOI
10.1016/S0378-3782(01)00199-2
language
English
LU publication?
yes
id
4f2145fd-42b0-4100-bf4f-db8d616bdce1 (old id 1122866)
date added to LUP
2008-06-27 14:07:40
date last changed
2018-01-07 09:36:29
@article{4f2145fd-42b0-4100-bf4f-db8d616bdce1,
  abstract     = {OBJECTIVES: To examine cardiovascular physiology in the healthy fetus during normal development. DESIGN: Twenty normal fetuses were studied longitudinally from 20 weeks to term. Serial echocardiography was performed, and arterial and venous diameter pulse wave characteristics and aortic pulse wave propagation velocity (PWV) were examined in the thoracic descending aorta (AoD) and inferior caval vein (IVC) using an ultrasonic phase-locked echo-tracking system. Statistical analyses included ANOVA, paired t-test and logistic regression where appropriate. RESULTS: Aortic PWV, maximum incremental and late decremental velocities increased with gestation while the relative pulse amplitude decreased, reflecting falling distal impedance. There was a linear increase in cardiac preload and relative pulse amplitude in the IVC with gestation that correlated significantly with the presence of end-diastolic flow in the pulmonary artery and improvement in right ventricular diastolic function. CONCLUSIONS: Non-invasive concurrent assessment of preload, ventricular function and impedance are possible in the fetus and may prove useful in the longitudinal study of fetal adaptation to pathophysiological changes.},
  author       = {Gardiner, Helena and Brodszki, Jana and Eriksson, Anders and Stale, Håkan and Marsal, Karel},
  issn         = {1872-6232},
  keyword      = {Fetus,Ultrasound,Vascular physiology,Echo-tracking,Pulse wave velocity},
  language     = {eng},
  number       = {2},
  pages        = {97--106},
  publisher    = {Elsevier},
  series       = {Early Human Development},
  title        = {Ventriculo-vascular interaction in the normal development of the fetal circulation},
  url          = {http://dx.doi.org/10.1016/S0378-3782(01)00199-2},
  volume       = {65},
  year         = {2001},
}