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Sympathetic dysfunction in patients with primary Sjogren's syndrome

Mandl, Thomas LU ; Bornmyr, S V; Castenfors, J; Jacobsson, L T; Manthorpe, Rolf LU and Wollmer, Per LU (2001) In Journal of Rheumatology 28(2). p.296-301
Abstract
OBJECTIVE: To investigate autonomic nervous system function in patients with primary Sjogren's syndrome (SS) and relate the findings to clinical variables. METHODS: Autonomic nervous system function was determined in 30 patients with primary SS using the finger skin blood flow test [vasoconstrictory (VAC) index], deep-breathing test [expiration/inspiration (E/I) ratio], and the tilt table (orthostatic) test [acceleration index (AI), brake index (BI), and orthostatic blood pressure]. The results were compared with age matched control materials (finger skin blood flow test, n = 80, and deep-breathing and tilt table tests, n = 56). RESULTS: The VAC index was found to be significantly increased and the E/I ratio significantly decreased in... (More)
OBJECTIVE: To investigate autonomic nervous system function in patients with primary Sjogren's syndrome (SS) and relate the findings to clinical variables. METHODS: Autonomic nervous system function was determined in 30 patients with primary SS using the finger skin blood flow test [vasoconstrictory (VAC) index], deep-breathing test [expiration/inspiration (E/I) ratio], and the tilt table (orthostatic) test [acceleration index (AI), brake index (BI), and orthostatic blood pressure]. The results were compared with age matched control materials (finger skin blood flow test, n = 80, and deep-breathing and tilt table tests, n = 56). RESULTS: The VAC index was found to be significantly increased and the E/I ratio significantly decreased in patients compared to controls, indicating both a sympathetic and a parasympathetic dysfunction. Further, the patients, especially the anti-SSA and anti-SSB antibody seropositives, were found to have an abnormal blood pressure reaction to tilt compared to controls. No correlations were found between autonomic nerve function variables measured and the clinical ophthalmologic or the oral tests, performed at the time of diagnosis. CONCLUSION: Patients with primary SS show signs of both sympathetic and parasympathetic dysfunction. Further, immunological mechanisms seem to influence blood pressure in patients with primary SS. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Rheumatology
volume
28
issue
2
pages
296 - 301
publisher
J Rheumatol Publ Co
external identifiers
  • pmid:11246665
ISSN
0315-162X
language
English
LU publication?
yes
id
5c155d3e-07cd-48ec-b838-ba20c9363e8d (old id 1122876)
date added to LUP
2008-07-04 13:55:12
date last changed
2018-05-29 12:09:32
@article{5c155d3e-07cd-48ec-b838-ba20c9363e8d,
  abstract     = {OBJECTIVE: To investigate autonomic nervous system function in patients with primary Sjogren's syndrome (SS) and relate the findings to clinical variables. METHODS: Autonomic nervous system function was determined in 30 patients with primary SS using the finger skin blood flow test [vasoconstrictory (VAC) index], deep-breathing test [expiration/inspiration (E/I) ratio], and the tilt table (orthostatic) test [acceleration index (AI), brake index (BI), and orthostatic blood pressure]. The results were compared with age matched control materials (finger skin blood flow test, n = 80, and deep-breathing and tilt table tests, n = 56). RESULTS: The VAC index was found to be significantly increased and the E/I ratio significantly decreased in patients compared to controls, indicating both a sympathetic and a parasympathetic dysfunction. Further, the patients, especially the anti-SSA and anti-SSB antibody seropositives, were found to have an abnormal blood pressure reaction to tilt compared to controls. No correlations were found between autonomic nerve function variables measured and the clinical ophthalmologic or the oral tests, performed at the time of diagnosis. CONCLUSION: Patients with primary SS show signs of both sympathetic and parasympathetic dysfunction. Further, immunological mechanisms seem to influence blood pressure in patients with primary SS.},
  author       = {Mandl, Thomas and Bornmyr, S V and Castenfors, J and Jacobsson, L T and Manthorpe, Rolf and Wollmer, Per},
  issn         = {0315-162X},
  language     = {eng},
  number       = {2},
  pages        = {296--301},
  publisher    = {J Rheumatol Publ Co},
  series       = {Journal of Rheumatology},
  title        = {Sympathetic dysfunction in patients with primary Sjogren's syndrome},
  volume       = {28},
  year         = {2001},
}