Breathing patterns and aerosol delivery: impact of regular human patterns, and sine and square waveforms on rate of delivery
(2001) In Journal of Aerosol Medicine 14(3). p.327-333- Abstract
- In vitro tests are commonly employed to assess nebulizer performance. Whether the square or sine waveforms employed during in vitro tests could alter the nebulizer performance compared to that observed when a patient breathes through the nebulizer is debatable. Accordingly, the aim of this in vitro study was to compare the rates of delivery from nebulizers with simulated human breathing patterns to those obtained with matching sine and square waveforms. Regular human breathing patterns with tidal volumes (VT) of approximately 40, approximately 200, approximately 500, and approximately 800 mL were selected. Sine and square waveforms that matched the VT, peak inspiratory flow rate (PIF), breathing frequency (f), and inspiratory duty cycle... (More)
- In vitro tests are commonly employed to assess nebulizer performance. Whether the square or sine waveforms employed during in vitro tests could alter the nebulizer performance compared to that observed when a patient breathes through the nebulizer is debatable. Accordingly, the aim of this in vitro study was to compare the rates of delivery from nebulizers with simulated human breathing patterns to those obtained with matching sine and square waveforms. Regular human breathing patterns with tidal volumes (VT) of approximately 40, approximately 200, approximately 500, and approximately 800 mL were selected. Sine and square waveforms that matched the VT, peak inspiratory flow rate (PIF), breathing frequency (f), and inspiratory duty cycle (t(i)/t(tot)) of the human breathing patterns were created with a breathing simulator. The rate of delivery of nebulized technetium-99m-labeled diethylenetriamine pentaacetic acid (99mTC-DTPA) from two different jet nebulizer brands was determined. The rate of delivery was defined as the amount of the 99mTC-DTPA deposited during 30 sec of nebulization on a filter placed between the nebulizer and the breathing simulator. The rate of delivery of 99mTC-DTPA with the human breathing pattern was similar to that measured with the matching sine or square waveforms for either nebulizer. The configuration of the breath (PIF, VT, f, t(i)/t(tot)) did, however, influence the rate of delivery. In conclusion, the shape of the waveform, in other words, one resulting from a human breathing pattern, or a matching sine or square waveform, did not influence the rate of 99mTC-DTPA delivery from a nebulizer in vitro. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1122881
- author
- Nikander, Kurt ; Denyer, John ; Smith, Nick and Wollmer, Per LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Aerosol Medicine
- volume
- 14
- issue
- 3
- pages
- 327 - 333
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- pmid:11693844
- scopus:0034864140
- ISSN
- 0894-2684
- DOI
- 10.1089/089426801316970286
- language
- English
- LU publication?
- yes
- id
- ea7535c6-8f56-45d9-8d20-b019022ecf77 (old id 1122881)
- date added to LUP
- 2016-04-01 16:15:48
- date last changed
- 2022-01-28 18:28:34
@article{ea7535c6-8f56-45d9-8d20-b019022ecf77,
abstract = {{In vitro tests are commonly employed to assess nebulizer performance. Whether the square or sine waveforms employed during in vitro tests could alter the nebulizer performance compared to that observed when a patient breathes through the nebulizer is debatable. Accordingly, the aim of this in vitro study was to compare the rates of delivery from nebulizers with simulated human breathing patterns to those obtained with matching sine and square waveforms. Regular human breathing patterns with tidal volumes (VT) of approximately 40, approximately 200, approximately 500, and approximately 800 mL were selected. Sine and square waveforms that matched the VT, peak inspiratory flow rate (PIF), breathing frequency (f), and inspiratory duty cycle (t(i)/t(tot)) of the human breathing patterns were created with a breathing simulator. The rate of delivery of nebulized technetium-99m-labeled diethylenetriamine pentaacetic acid (99mTC-DTPA) from two different jet nebulizer brands was determined. The rate of delivery was defined as the amount of the 99mTC-DTPA deposited during 30 sec of nebulization on a filter placed between the nebulizer and the breathing simulator. The rate of delivery of 99mTC-DTPA with the human breathing pattern was similar to that measured with the matching sine or square waveforms for either nebulizer. The configuration of the breath (PIF, VT, f, t(i)/t(tot)) did, however, influence the rate of delivery. In conclusion, the shape of the waveform, in other words, one resulting from a human breathing pattern, or a matching sine or square waveform, did not influence the rate of 99mTC-DTPA delivery from a nebulizer in vitro.}},
author = {{Nikander, Kurt and Denyer, John and Smith, Nick and Wollmer, Per}},
issn = {{0894-2684}},
language = {{eng}},
number = {{3}},
pages = {{327--333}},
publisher = {{Mary Ann Liebert, Inc.}},
series = {{Journal of Aerosol Medicine}},
title = {{Breathing patterns and aerosol delivery: impact of regular human patterns, and sine and square waveforms on rate of delivery}},
url = {{http://dx.doi.org/10.1089/089426801316970286}},
doi = {{10.1089/089426801316970286}},
volume = {{14}},
year = {{2001}},
}