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Air pollutants and tear film stability--a method for experimental evaluation

Zhao, Jiang and Wollmer, Per LU (2001) In Clinical Physiology 21(3). p.282-286
Abstract
Instability of the pre-ocular tear film causes symptoms of dry eyes. Tear film instability may be caused by exposure to air pollutants, but identification of causative agents is often difficult. We describe an in vitro technique for assessment of putative agents on the surface activity of Meibomian lipids. The lipids were obtained from bovine eyelids and dissolved in chloroform. Surface activity of the solution was assessed on a Wilhelmy balance. After addition of benzalkonium chloride, minimum surface tension of the lipids increased and maximum surface tension fell. After addition of quartz particles, both maximum and minimum surface tension increased. The method can be used to screen substances suspected to cause dry eyes, providing a... (More)
Instability of the pre-ocular tear film causes symptoms of dry eyes. Tear film instability may be caused by exposure to air pollutants, but identification of causative agents is often difficult. We describe an in vitro technique for assessment of putative agents on the surface activity of Meibomian lipids. The lipids were obtained from bovine eyelids and dissolved in chloroform. Surface activity of the solution was assessed on a Wilhelmy balance. After addition of benzalkonium chloride, minimum surface tension of the lipids increased and maximum surface tension fell. After addition of quartz particles, both maximum and minimum surface tension increased. The method can be used to screen substances suspected to cause dry eyes, providing a basis for selection of substances for in vivo studies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Physiology
volume
21
issue
3
pages
282 - 286
publisher
Wiley Online Library
external identifiers
  • pmid:11380526
  • scopus:0035018778
ISSN
1365-2281
DOI
10.1046/j.1365-2281.2001.00329.x
language
English
LU publication?
yes
id
55dbba6c-bdf7-47ec-916c-49dff50dae21 (old id 1122886)
date added to LUP
2008-07-18 16:33:40
date last changed
2018-05-29 10:32:07
@article{55dbba6c-bdf7-47ec-916c-49dff50dae21,
  abstract     = {Instability of the pre-ocular tear film causes symptoms of dry eyes. Tear film instability may be caused by exposure to air pollutants, but identification of causative agents is often difficult. We describe an in vitro technique for assessment of putative agents on the surface activity of Meibomian lipids. The lipids were obtained from bovine eyelids and dissolved in chloroform. Surface activity of the solution was assessed on a Wilhelmy balance. After addition of benzalkonium chloride, minimum surface tension of the lipids increased and maximum surface tension fell. After addition of quartz particles, both maximum and minimum surface tension increased. The method can be used to screen substances suspected to cause dry eyes, providing a basis for selection of substances for in vivo studies.},
  author       = {Zhao, Jiang and Wollmer, Per},
  issn         = {1365-2281},
  language     = {eng},
  number       = {3},
  pages        = {282--286},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology},
  title        = {Air pollutants and tear film stability--a method for experimental evaluation},
  url          = {http://dx.doi.org/10.1046/j.1365-2281.2001.00329.x},
  volume       = {21},
  year         = {2001},
}