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Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect

Aase, Karin; von Euler, Gabriel; Li, Xuri; Pontén, Annica LU ; Thoren, Peter; Cao, Renhai; Cao, Yihai; Olofsson, Birgitta; Gebre-Medhin, Samuel and Pekny, Milos, et al. (2001) In Circulation 104(3). p.358-358
Abstract
BACKGROUND: Vascular endothelial growth factors (VEGFs) and their receptors are essential regulators of vasculogenesis and angiogenesis in both embryos and adults. One of the factors with a still unknown physiological function is VEGF-B, which is expressed in many tissues, including the heart. METHODS AND RESULTS: Mice carrying a targeted deletion in the VEGF-B gene were developed. In VEGF-B(-/-) animals, no gross abnormalities were observed in organs that normally show high expression of VEGF-B, such as the heart, muscle, and kidney. Analysis of heart function by ECG showed that adult VEGF-B(-/-) mice have an atrial conduction abnormality characterized by a prolonged PQ interval. VEGF- or basic fibroblast growth factor-induced corneal... (More)
BACKGROUND: Vascular endothelial growth factors (VEGFs) and their receptors are essential regulators of vasculogenesis and angiogenesis in both embryos and adults. One of the factors with a still unknown physiological function is VEGF-B, which is expressed in many tissues, including the heart. METHODS AND RESULTS: Mice carrying a targeted deletion in the VEGF-B gene were developed. In VEGF-B(-/-) animals, no gross abnormalities were observed in organs that normally show high expression of VEGF-B, such as the heart, muscle, and kidney. Analysis of heart function by ECG showed that adult VEGF-B(-/-) mice have an atrial conduction abnormality characterized by a prolonged PQ interval. VEGF- or basic fibroblast growth factor-induced corneal angiogenesis was similar in normal and VEGF-B(-/-) mice. CONCLUSIONS: VEGF-B seems to be required for normal heart function in adult animals but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
electrocardiography, growth substances, angiogenesis, atrium, conduction
in
Circulation
volume
104
issue
3
pages
358 - 358
publisher
Lippincott Williams and Wilkins
external identifiers
  • pmid:11457758
  • scopus:0035902538
ISSN
1524-4539
language
English
LU publication?
no
id
6e9e3b42-b398-473f-bd92-9e16238dcce1 (old id 1122970)
alternative location
http://circ.ahajournals.org/cgi/content/full/104/3/358
date added to LUP
2008-06-23 11:51:53
date last changed
2018-01-21 03:52:24
@article{6e9e3b42-b398-473f-bd92-9e16238dcce1,
  abstract     = {BACKGROUND: Vascular endothelial growth factors (VEGFs) and their receptors are essential regulators of vasculogenesis and angiogenesis in both embryos and adults. One of the factors with a still unknown physiological function is VEGF-B, which is expressed in many tissues, including the heart. METHODS AND RESULTS: Mice carrying a targeted deletion in the VEGF-B gene were developed. In VEGF-B(-/-) animals, no gross abnormalities were observed in organs that normally show high expression of VEGF-B, such as the heart, muscle, and kidney. Analysis of heart function by ECG showed that adult VEGF-B(-/-) mice have an atrial conduction abnormality characterized by a prolonged PQ interval. VEGF- or basic fibroblast growth factor-induced corneal angiogenesis was similar in normal and VEGF-B(-/-) mice. CONCLUSIONS: VEGF-B seems to be required for normal heart function in adult animals but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults.},
  author       = {Aase, Karin and von Euler, Gabriel and Li, Xuri and Pontén, Annica and Thoren, Peter and Cao, Renhai and Cao, Yihai and Olofsson, Birgitta and Gebre-Medhin, Samuel and Pekny, Milos and Alitalo, Kari and Betsholtz, Christer and Eriksson, Ulf},
  issn         = {1524-4539},
  keyword      = {electrocardiography,growth substances,angiogenesis,atrium,conduction},
  language     = {eng},
  number       = {3},
  pages        = {358--358},
  publisher    = {Lippincott Williams and Wilkins},
  series       = {Circulation},
  title        = {Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect},
  volume       = {104},
  year         = {2001},
}