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Molar pregnancy with a coexistent fetus after intracytoplasmic sperm injection. A case report

Petignat, Patrick ; Senn, Alfred ; Hohlfeld, Patrick ; Blant, Snezana Andrejevic ; Laurini, Ricardo LU and Germond, Marc (2001) In Journal of Reproductive Medicine 46(3). p.270-274
Abstract
BACKGROUND: Normal fertilization is usually considered to have occurred when two pronculei (2PN) and two polar bodies are observed. Exceptions are the single pronucleated zygote resulting from asynchronous pronuclei. CASE: A 29-year-old woman entered a program of intracytoplasmic sperm injection and embryo transfer because of her husband's oligoasthenoteratozoospermia. Two cleavage-stage embryos (four blastomeres, grade 1 and 2) were obtained from one fertilized oocyte containing distinct 2PN and the other a single pronucleus (1PN). At 15 weeks' gestation the patient developed severe preeclampsia requiring termination of the pregnancy. Histopathologic examination and DNA ploidy by image analysis were consistent with a twin pregnancy... (More)
BACKGROUND: Normal fertilization is usually considered to have occurred when two pronculei (2PN) and two polar bodies are observed. Exceptions are the single pronucleated zygote resulting from asynchronous pronuclei. CASE: A 29-year-old woman entered a program of intracytoplasmic sperm injection and embryo transfer because of her husband's oligoasthenoteratozoospermia. Two cleavage-stage embryos (four blastomeres, grade 1 and 2) were obtained from one fertilized oocyte containing distinct 2PN and the other a single pronucleus (1PN). At 15 weeks' gestation the patient developed severe preeclampsia requiring termination of the pregnancy. Histopathologic examination and DNA ploidy by image analysis were consistent with a twin pregnancy combining a complete hydatidiform mole and normal pregnancy. CONCLUSION: We hypothesize that this 1PN was at the origin of the hydatidiform mole. This case highlights the danger of transferring an embryo having 1PN. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pregnancy complications, molar pregnancy, intracytoplasmic sperm injections
in
Journal of Reproductive Medicine
volume
46
issue
3
pages
270 - 274
publisher
Journal of Reproductive Medicine, Inc.
external identifiers
  • pmid:11304873
  • scopus:0035044246
ISSN
0024-7758
language
English
LU publication?
yes
id
7fd9edab-0416-498a-bdb7-2f2f3233844b (old id 1123001)
date added to LUP
2016-04-01 16:49:03
date last changed
2025-04-04 15:08:45
@article{7fd9edab-0416-498a-bdb7-2f2f3233844b,
  abstract     = {{BACKGROUND: Normal fertilization is usually considered to have occurred when two pronculei (2PN) and two polar bodies are observed. Exceptions are the single pronucleated zygote resulting from asynchronous pronuclei. CASE: A 29-year-old woman entered a program of intracytoplasmic sperm injection and embryo transfer because of her husband's oligoasthenoteratozoospermia. Two cleavage-stage embryos (four blastomeres, grade 1 and 2) were obtained from one fertilized oocyte containing distinct 2PN and the other a single pronucleus (1PN). At 15 weeks' gestation the patient developed severe preeclampsia requiring termination of the pregnancy. Histopathologic examination and DNA ploidy by image analysis were consistent with a twin pregnancy combining a complete hydatidiform mole and normal pregnancy. CONCLUSION: We hypothesize that this 1PN was at the origin of the hydatidiform mole. This case highlights the danger of transferring an embryo having 1PN.}},
  author       = {{Petignat, Patrick and Senn, Alfred and Hohlfeld, Patrick and Blant, Snezana Andrejevic and Laurini, Ricardo and Germond, Marc}},
  issn         = {{0024-7758}},
  keywords     = {{pregnancy complications; molar pregnancy; intracytoplasmic sperm injections}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{270--274}},
  publisher    = {{Journal of Reproductive Medicine, Inc.}},
  series       = {{Journal of Reproductive Medicine}},
  title        = {{Molar pregnancy with a coexistent fetus after intracytoplasmic sperm injection. A case report}},
  volume       = {{46}},
  year         = {{2001}},
}