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Sd(a)-antigen-like structures carried on core 3 are prominent features of glycans from the mucin of normal human descending colon

Capon, C; Maes, E; Michalski, J C; Leffler, Hakon LU and Kim, Y S (2001) In Biochemical Journal 358(Pt 3). p.657-664
Abstract
This paper describes structural characterization by NMR, MS and degradative studies of mucin glycans from normal human descending colon obtained freshly at autopsy. The saccharides were mainly based on core 3 (GlcNAcbeta1-3GalNAc). Among the terminal saccharide determinants Sd(a)/Cad-antigen-like structures were prominent, and Lewis x, sialyl Lewis x and sulphated Lewis x were found as minor components, whereas blood group H and A antigenic determinants were absent. The saccharides were markedly different from those of mucins from colon cancers or colon cancer cell lines analysed so far, in which cores 1 and 2 are prominent features, and in which various other terminal determinants have been found, but not Sd(a)/Cad.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical Journal
volume
358
issue
Pt 3
pages
657 - 664
publisher
Portland Press Limited
external identifiers
  • pmid:11577689
  • scopus:0035884645
ISSN
0264-6021
language
English
LU publication?
yes
id
b1cf1790-2124-4794-9bcb-989c99afa760 (old id 1123037)
date added to LUP
2008-06-25 14:55:53
date last changed
2018-05-29 10:24:07
@article{b1cf1790-2124-4794-9bcb-989c99afa760,
  abstract     = {This paper describes structural characterization by NMR, MS and degradative studies of mucin glycans from normal human descending colon obtained freshly at autopsy. The saccharides were mainly based on core 3 (GlcNAcbeta1-3GalNAc). Among the terminal saccharide determinants Sd(a)/Cad-antigen-like structures were prominent, and Lewis x, sialyl Lewis x and sulphated Lewis x were found as minor components, whereas blood group H and A antigenic determinants were absent. The saccharides were markedly different from those of mucins from colon cancers or colon cancer cell lines analysed so far, in which cores 1 and 2 are prominent features, and in which various other terminal determinants have been found, but not Sd(a)/Cad.},
  author       = {Capon, C and Maes, E and Michalski, J C and Leffler, Hakon and Kim, Y S},
  issn         = {0264-6021},
  language     = {eng},
  number       = {Pt 3},
  pages        = {657--664},
  publisher    = {Portland Press Limited},
  series       = {Biochemical Journal},
  title        = {Sd(a)-antigen-like structures carried on core 3 are prominent features of glycans from the mucin of normal human descending colon},
  volume       = {358},
  year         = {2001},
}