Advanced

C-terminal flanking peptide of neuropeptide Y in DRG following nerve compression

Widerberg, Annika LU ; Kanje, Martin LU and Dahlin, Lars LU (2001) In NeuroReport 12(15). p.3193-3196
Abstract
The C-terminal flanking peptide of neuropeptide Y (CPON) was studied in dorsal root ganglia (DRG) by immunocytochemistry after different recovery periods (3, 6,14 and 28 days) following tourniquet compression of the rat hindlimb (sciatic nerve; 150 or 300 mmHg; 2 h). Compression induced a transient increase in the number of CPON-positive DRG-neurons (the contralateral uninjured side was devoid of CPON-positive cells). The compression-induced increase in CPON was less than that observed in separate rats subjected to sciatic nerve transection. The results show that compression induces regenerative changes in peripheral neurons and that such an injury of the nerve trunk is not limited to the site of the compression but results in the... (More)
The C-terminal flanking peptide of neuropeptide Y (CPON) was studied in dorsal root ganglia (DRG) by immunocytochemistry after different recovery periods (3, 6,14 and 28 days) following tourniquet compression of the rat hindlimb (sciatic nerve; 150 or 300 mmHg; 2 h). Compression induced a transient increase in the number of CPON-positive DRG-neurons (the contralateral uninjured side was devoid of CPON-positive cells). The compression-induced increase in CPON was less than that observed in separate rats subjected to sciatic nerve transection. The results show that compression induces regenerative changes in peripheral neurons and that such an injury of the nerve trunk is not limited to the site of the compression but results in the activation of the entire neuron. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C-terminal flanking peptide of neuropeptide Y (CPON), Nerve compression, Nerve injury, Neuron, Neuropeptide Y, NPY, Tourniquet
in
NeuroReport
volume
12
issue
15
pages
3193 - 3196
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:11711854
  • scopus:0035968918
ISSN
1473-558X
language
English
LU publication?
yes
id
76e09179-8244-428c-984d-d270ac16c832 (old id 1123093)
date added to LUP
2008-07-18 14:26:25
date last changed
2018-05-29 10:01:20
@article{76e09179-8244-428c-984d-d270ac16c832,
  abstract     = {The C-terminal flanking peptide of neuropeptide Y (CPON) was studied in dorsal root ganglia (DRG) by immunocytochemistry after different recovery periods (3, 6,14 and 28 days) following tourniquet compression of the rat hindlimb (sciatic nerve; 150 or 300 mmHg; 2 h). Compression induced a transient increase in the number of CPON-positive DRG-neurons (the contralateral uninjured side was devoid of CPON-positive cells). The compression-induced increase in CPON was less than that observed in separate rats subjected to sciatic nerve transection. The results show that compression induces regenerative changes in peripheral neurons and that such an injury of the nerve trunk is not limited to the site of the compression but results in the activation of the entire neuron.},
  author       = {Widerberg, Annika and Kanje, Martin and Dahlin, Lars},
  issn         = {1473-558X},
  keyword      = {C-terminal flanking peptide of neuropeptide Y (CPON),Nerve compression,Nerve injury,Neuron,Neuropeptide Y,NPY,Tourniquet},
  language     = {eng},
  number       = {15},
  pages        = {3193--3196},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {C-terminal flanking peptide of neuropeptide Y in DRG following nerve compression},
  volume       = {12},
  year         = {2001},
}