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The Cromer blood group system: a review

Storry, Jill LU and Reid, M E (2002) In Immunohematology 18(4). p.95-95
Abstract
The antigens of the Cromer blood group system reside on decay accelerating factor (DAF), a protein belonging to the regulators of complement activation family. The blood group system consists of eight high-incidence antigens and three low-incidence antigens. The molecular basis for the antigens is known and, with the exception of IFC, each antigen is the product of a single nucleotide polymorphism in the DAF gene and has been localized to one of the four short consensus repeat regions on the DAF protein. The red blood cells (RBCs) of people with the Cromer null phenotype, Inab, lack DAF. Antibodies to Cromer antigens are rarely encountered although there is evidence that the antibodies may cause accelerated destruction of transfused RBCs.... (More)
The antigens of the Cromer blood group system reside on decay accelerating factor (DAF), a protein belonging to the regulators of complement activation family. The blood group system consists of eight high-incidence antigens and three low-incidence antigens. The molecular basis for the antigens is known and, with the exception of IFC, each antigen is the product of a single nucleotide polymorphism in the DAF gene and has been localized to one of the four short consensus repeat regions on the DAF protein. The red blood cells (RBCs) of people with the Cromer null phenotype, Inab, lack DAF. Antibodies to Cromer antigens are rarely encountered although there is evidence that the antibodies may cause accelerated destruction of transfused RBCs. There is no risk of hemolytic disease of the newborn associated with Cromer system antibodies because the placenta is a rich source of fetally derived DAF, which is thought to adsorb the antibodies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunohematology
volume
18
issue
4
pages
95 - 95
publisher
American Red Cross
external identifiers
  • pmid:15373545
  • scopus:0036447563
ISSN
0894-203X
language
English
LU publication?
yes
id
d55168e6-f7bd-4777-9b8c-936813a39594 (old id 1123930)
date added to LUP
2008-06-02 13:21:14
date last changed
2017-01-01 07:20:11
@article{d55168e6-f7bd-4777-9b8c-936813a39594,
  abstract     = {The antigens of the Cromer blood group system reside on decay accelerating factor (DAF), a protein belonging to the regulators of complement activation family. The blood group system consists of eight high-incidence antigens and three low-incidence antigens. The molecular basis for the antigens is known and, with the exception of IFC, each antigen is the product of a single nucleotide polymorphism in the DAF gene and has been localized to one of the four short consensus repeat regions on the DAF protein. The red blood cells (RBCs) of people with the Cromer null phenotype, Inab, lack DAF. Antibodies to Cromer antigens are rarely encountered although there is evidence that the antibodies may cause accelerated destruction of transfused RBCs. There is no risk of hemolytic disease of the newborn associated with Cromer system antibodies because the placenta is a rich source of fetally derived DAF, which is thought to adsorb the antibodies.},
  author       = {Storry, Jill and Reid, M E},
  issn         = {0894-203X},
  language     = {eng},
  number       = {4},
  pages        = {95--95},
  publisher    = {American Red Cross},
  series       = {Immunohematology},
  title        = {The Cromer blood group system: a review},
  volume       = {18},
  year         = {2002},
}