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Effects of montelukast on physical performance and exercise economy in adult asthmatics with exercise-induced bronchoconstriction

Steinshamn, Sigurd; Sandsund, M; Sue-Chu, M and Bjermer, Leif LU (2002) In Scandinavian Journal of Medicine & Science in Sports 12(4). p.211-217
Abstract
Leukotriene antagonists are effective in the treatment of exercise-induced bronchoconstriction. Montelukast is a specific cysteinyl-leukotriene receptor1 antagonist without known effects on the pulmonary vessels, which in theory should be advantageous with respect to gas exchange. In addition to lung function, we investigated the effects of montelukast on parameters of gas exchange and physical performance in 16 asthmatics with exercise-induced bronchoconstriction in a double-blind cross-over placebo-controlled study. Subjects were tested at an ambient temperature of -15 degrees C with a tread mill exercise protocol consisting of consecutive workloads of 80% V'O(2max) (6 min), rest (4 min), 60% V'O(2max) (6 min) and step increments of... (More)
Leukotriene antagonists are effective in the treatment of exercise-induced bronchoconstriction. Montelukast is a specific cysteinyl-leukotriene receptor1 antagonist without known effects on the pulmonary vessels, which in theory should be advantageous with respect to gas exchange. In addition to lung function, we investigated the effects of montelukast on parameters of gas exchange and physical performance in 16 asthmatics with exercise-induced bronchoconstriction in a double-blind cross-over placebo-controlled study. Subjects were tested at an ambient temperature of -15 degrees C with a tread mill exercise protocol consisting of consecutive workloads of 80% V'O(2max) (6 min), rest (4 min), 60% V'O(2max) (6 min) and step increments of exercise until exhaustion. Montelukast reduced the maximum post-exercise fall in FEV1 (P < 0.01), improved the running time to exhaustion in 11 of 16 test subjects (one unchanged) (P = 0.03), and reduced the Borg score at exhaustion (P = 0.03) and the breathing frequency after 3 min at 60% V'O(2max) (P = 0.03). V'(O2), V'CO(2), minute ventilation, ventilatory equivalents, respiratory exchange ratio, heart rate and oxygen pulse were not significantly different after montelukast and placebo. We conclude that montelukast has a beneficial effect on physical performance in most adults with exercise-induced asthma without any observed effect on gas-exchange parameters. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Medicine & Science in Sports
volume
12
issue
4
pages
211 - 217
publisher
Wiley-Blackwell
external identifiers
  • pmid:12199869
  • scopus:0036691025
ISSN
1600-0838
DOI
10.1034/j.1600-0838.2002.00225.x
language
English
LU publication?
no
id
629e1ea2-4d1b-4e4c-a74a-362c9db6d711 (old id 1123968)
date added to LUP
2008-06-02 13:19:52
date last changed
2017-01-01 07:06:54
@article{629e1ea2-4d1b-4e4c-a74a-362c9db6d711,
  abstract     = {Leukotriene antagonists are effective in the treatment of exercise-induced bronchoconstriction. Montelukast is a specific cysteinyl-leukotriene receptor1 antagonist without known effects on the pulmonary vessels, which in theory should be advantageous with respect to gas exchange. In addition to lung function, we investigated the effects of montelukast on parameters of gas exchange and physical performance in 16 asthmatics with exercise-induced bronchoconstriction in a double-blind cross-over placebo-controlled study. Subjects were tested at an ambient temperature of -15 degrees C with a tread mill exercise protocol consisting of consecutive workloads of 80% V'O(2max) (6 min), rest (4 min), 60% V'O(2max) (6 min) and step increments of exercise until exhaustion. Montelukast reduced the maximum post-exercise fall in FEV1 (P &lt; 0.01), improved the running time to exhaustion in 11 of 16 test subjects (one unchanged) (P = 0.03), and reduced the Borg score at exhaustion (P = 0.03) and the breathing frequency after 3 min at 60% V'O(2max) (P = 0.03). V'(O2), V'CO(2), minute ventilation, ventilatory equivalents, respiratory exchange ratio, heart rate and oxygen pulse were not significantly different after montelukast and placebo. We conclude that montelukast has a beneficial effect on physical performance in most adults with exercise-induced asthma without any observed effect on gas-exchange parameters.},
  author       = {Steinshamn, Sigurd and Sandsund, M and Sue-Chu, M and Bjermer, Leif},
  issn         = {1600-0838},
  language     = {eng},
  number       = {4},
  pages        = {211--217},
  publisher    = {Wiley-Blackwell},
  series       = {Scandinavian Journal of Medicine & Science in Sports},
  title        = {Effects of montelukast on physical performance and exercise economy in adult asthmatics with exercise-induced bronchoconstriction},
  url          = {http://dx.doi.org/10.1034/j.1600-0838.2002.00225.x},
  volume       = {12},
  year         = {2002},
}