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Effect of graded testicular doses of radiotherapy in patients treated for carcinoma-in-situ in the testis

Petersen, Peter Meidahl; Giwercman, Aleksander LU ; Daugaard, Gedske; Rorth, Mikael; Petersen, Jorgen Holm; Skakkeaek, Niels E; Hansen, Steen W and von der Maase, Hans (2002) In Journal of Clinical Oncology 20(6). p.1537-1537
Abstract
PURPOSE: To determine the effect of radiotherapy in doses 14 to 20 Gy on eradication of carcinoma-in-situ (CIS) testis and on the Leydig cell function. PATIENTS AND METHODS: Forty-eight patients presented with unilateral testicular germ cell cancer and CIS of the contralateral testis. The CIS-bearing testis was treated with daily irradiation doses of 2 Gy, 5 days a week, to a cumulative dose of 20 Gy (21 patients), 18 Gy (three patients), 16 Gy (10 patients), and 14 Gy (14 patients). RESULTS: All patients treated at dose levels 20 Gy to 16 Gy achieved histologically verified complete remission without signs of recurrence of CIS after an observation period of more than 5 years. One of 14 patients treated at dose level 14 Gy had a relapse of... (More)
PURPOSE: To determine the effect of radiotherapy in doses 14 to 20 Gy on eradication of carcinoma-in-situ (CIS) testis and on the Leydig cell function. PATIENTS AND METHODS: Forty-eight patients presented with unilateral testicular germ cell cancer and CIS of the contralateral testis. The CIS-bearing testis was treated with daily irradiation doses of 2 Gy, 5 days a week, to a cumulative dose of 20 Gy (21 patients), 18 Gy (three patients), 16 Gy (10 patients), and 14 Gy (14 patients). RESULTS: All patients treated at dose levels 20 Gy to 16 Gy achieved histologically verified complete remission without signs of recurrence of CIS after an observation period of more than 5 years. One of 14 patients treated at dose level 14 Gy had a relapse of CIS 20 months after irradiation. Leydig cell function was examined before and regularly after radiotherapy in 44 of 48 patients. The levels of testosterone were lower after radiotherapy than before. Testosterone showed a stable decrease for more than 5 years after treatment (3.6% per year) without dose dependency. The levels of luteinizing hormone and follicle-stimulating hormone were increased after radiotherapy. The need of androgen substitution therapy was similar at all dose levels. CONCLUSION: Testicular irradiation is a safe treatment at dose level 20 Gy (10 x 2 Gy). Decrease of dose to 14 Gy (7 x 2 Gy) might lead to risk of relapse of CIS. Impairment of hormone production without clinically significant dose dependency is seen in the dose range 14 to 20 Gy. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Oncology
volume
20
issue
6
pages
1537 - 1537
publisher
American Society of Clinical Oncology
external identifiers
  • pmid:11896102
  • scopus:0037087788
ISSN
1527-7755
language
English
LU publication?
no
id
9e262861-c264-457f-8d98-89b9434ce4e4 (old id 1124251)
alternative location
http://jco.ascopubs.org/cgi/content/abstract/20/6/1537
date added to LUP
2008-05-29 14:23:38
date last changed
2017-10-22 03:40:54
@article{9e262861-c264-457f-8d98-89b9434ce4e4,
  abstract     = {PURPOSE: To determine the effect of radiotherapy in doses 14 to 20 Gy on eradication of carcinoma-in-situ (CIS) testis and on the Leydig cell function. PATIENTS AND METHODS: Forty-eight patients presented with unilateral testicular germ cell cancer and CIS of the contralateral testis. The CIS-bearing testis was treated with daily irradiation doses of 2 Gy, 5 days a week, to a cumulative dose of 20 Gy (21 patients), 18 Gy (three patients), 16 Gy (10 patients), and 14 Gy (14 patients). RESULTS: All patients treated at dose levels 20 Gy to 16 Gy achieved histologically verified complete remission without signs of recurrence of CIS after an observation period of more than 5 years. One of 14 patients treated at dose level 14 Gy had a relapse of CIS 20 months after irradiation. Leydig cell function was examined before and regularly after radiotherapy in 44 of 48 patients. The levels of testosterone were lower after radiotherapy than before. Testosterone showed a stable decrease for more than 5 years after treatment (3.6% per year) without dose dependency. The levels of luteinizing hormone and follicle-stimulating hormone were increased after radiotherapy. The need of androgen substitution therapy was similar at all dose levels. CONCLUSION: Testicular irradiation is a safe treatment at dose level 20 Gy (10 x 2 Gy). Decrease of dose to 14 Gy (7 x 2 Gy) might lead to risk of relapse of CIS. Impairment of hormone production without clinically significant dose dependency is seen in the dose range 14 to 20 Gy.},
  author       = {Petersen, Peter Meidahl and Giwercman, Aleksander and Daugaard, Gedske and Rorth, Mikael and Petersen, Jorgen Holm and Skakkeaek, Niels E and Hansen, Steen W and von der Maase, Hans},
  issn         = {1527-7755},
  language     = {eng},
  number       = {6},
  pages        = {1537--1537},
  publisher    = {American Society of Clinical Oncology},
  series       = {Journal of Clinical Oncology},
  title        = {Effect of graded testicular doses of radiotherapy in patients treated for carcinoma-in-situ in the testis},
  volume       = {20},
  year         = {2002},
}