The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats.
Clark, L ; Greenbaum, C ; Jiang, J ; Lernmark, Åke LU
and Ochs, H
(2002)
In Pathogens and Disease
32(3).
p.205-209
- Abstract
- Congenic BioBreeding (BB) rats, homozygous for the autosomal lymphopenia (Lyp) gene (Lyp/Lyp), heterozygous (Lyp/+), or wild-type (+/+), were immunized with the T cell-dependent bacteriophage PhiX174 to determine effects of Lyp on primary and secondary antibody responses. The primary PhiX174 antibody response did not differ between the three different genotypes. In contrast, the secondary immune response, expressed as the peak neutralizing titer, was markedly reduced in Lyp/Lyp (9.9+/-3.2; mean value+/-S.E.M. for seven rats) compared to both Lyp/+ (51+/-12; n=13; P=0.006) and +/+ (100+/-20; n=7; P=0.004) BB rats. We suggest that the secondary antibody response to the T cell-dependent neoantigen PhiX174 is linked in a recessive manner to... (More)
- Congenic BioBreeding (BB) rats, homozygous for the autosomal lymphopenia (Lyp) gene (Lyp/Lyp), heterozygous (Lyp/+), or wild-type (+/+), were immunized with the T cell-dependent bacteriophage PhiX174 to determine effects of Lyp on primary and secondary antibody responses. The primary PhiX174 antibody response did not differ between the three different genotypes. In contrast, the secondary immune response, expressed as the peak neutralizing titer, was markedly reduced in Lyp/Lyp (9.9+/-3.2; mean value+/-S.E.M. for seven rats) compared to both Lyp/+ (51+/-12; n=13; P=0.006) and +/+ (100+/-20; n=7; P=0.004) BB rats. We suggest that the secondary antibody response to the T cell-dependent neoantigen PhiX174 is linked in a recessive manner to genetic factor(s) in the Lyp gene region. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1124261
- author
- Clark, L
; Greenbaum, C
; Jiang, J
; Lernmark, Åke
LU
and Ochs, H
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pathogens and Disease
- volume
- 32
- issue
- 3
- pages
- 205 - 209
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0037128130
- ISSN
- 2049-632X
- DOI
- 10.1111/j.1574-695X.2002.tb00555.x
- language
- English
- LU publication?
- no
- id
- 30036762-18ae-4138-bec9-8c73059354cc (old id 1124261)
- date added to LUP
- 2016-04-01 11:42:58
- date last changed
- 2022-01-26 17:12:01
@article{30036762-18ae-4138-bec9-8c73059354cc,
abstract = {{Congenic BioBreeding (BB) rats, homozygous for the autosomal lymphopenia (Lyp) gene (Lyp/Lyp), heterozygous (Lyp/+), or wild-type (+/+), were immunized with the T cell-dependent bacteriophage PhiX174 to determine effects of Lyp on primary and secondary antibody responses. The primary PhiX174 antibody response did not differ between the three different genotypes. In contrast, the secondary immune response, expressed as the peak neutralizing titer, was markedly reduced in Lyp/Lyp (9.9+/-3.2; mean value+/-S.E.M. for seven rats) compared to both Lyp/+ (51+/-12; n=13; P=0.006) and +/+ (100+/-20; n=7; P=0.004) BB rats. We suggest that the secondary antibody response to the T cell-dependent neoantigen PhiX174 is linked in a recessive manner to genetic factor(s) in the Lyp gene region.}},
author = {{Clark, L and Greenbaum, C and Jiang, J and Lernmark, Åke and Ochs, H}},
issn = {{2049-632X}},
language = {{eng}},
number = {{3}},
pages = {{205--209}},
publisher = {{Wiley-Blackwell}},
series = {{Pathogens and Disease}},
title = {{The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats.}},
url = {{http://dx.doi.org/10.1111/j.1574-695X.2002.tb00555.x}},
doi = {{10.1111/j.1574-695X.2002.tb00555.x}},
volume = {{32}},
year = {{2002}},
}