Advanced

The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats.

Clark, L; Greenbaum, C; Jiang, J; Lernmark, Åke LU and Ochs, H (2002) In Pathogens and Disease 32(3). p.205-209
Abstract
Congenic BioBreeding (BB) rats, homozygous for the autosomal lymphopenia (Lyp) gene (Lyp/Lyp), heterozygous (Lyp/+), or wild-type (+/+), were immunized with the T cell-dependent bacteriophage PhiX174 to determine effects of Lyp on primary and secondary antibody responses. The primary PhiX174 antibody response did not differ between the three different genotypes. In contrast, the secondary immune response, expressed as the peak neutralizing titer, was markedly reduced in Lyp/Lyp (9.9+/-3.2; mean value+/-S.E.M. for seven rats) compared to both Lyp/+ (51+/-12; n=13; P=0.006) and +/+ (100+/-20; n=7; P=0.004) BB rats. We suggest that the secondary antibody response to the T cell-dependent neoantigen PhiX174 is linked in a recessive manner to... (More)
Congenic BioBreeding (BB) rats, homozygous for the autosomal lymphopenia (Lyp) gene (Lyp/Lyp), heterozygous (Lyp/+), or wild-type (+/+), were immunized with the T cell-dependent bacteriophage PhiX174 to determine effects of Lyp on primary and secondary antibody responses. The primary PhiX174 antibody response did not differ between the three different genotypes. In contrast, the secondary immune response, expressed as the peak neutralizing titer, was markedly reduced in Lyp/Lyp (9.9+/-3.2; mean value+/-S.E.M. for seven rats) compared to both Lyp/+ (51+/-12; n=13; P=0.006) and +/+ (100+/-20; n=7; P=0.004) BB rats. We suggest that the secondary antibody response to the T cell-dependent neoantigen PhiX174 is linked in a recessive manner to genetic factor(s) in the Lyp gene region. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Pathogens and Disease
volume
32
issue
3
pages
205 - 209
publisher
Wiley-Blackwell
external identifiers
  • scopus:0037128130
ISSN
2049-632X
DOI
10.1111/j.1574-695X.2002.tb00555.x
language
English
LU publication?
no
id
30036762-18ae-4138-bec9-8c73059354cc (old id 1124261)
date added to LUP
2008-05-20 13:25:27
date last changed
2017-01-01 04:28:20
@article{30036762-18ae-4138-bec9-8c73059354cc,
  abstract     = {Congenic BioBreeding (BB) rats, homozygous for the autosomal lymphopenia (Lyp) gene (Lyp/Lyp), heterozygous (Lyp/+), or wild-type (+/+), were immunized with the T cell-dependent bacteriophage PhiX174 to determine effects of Lyp on primary and secondary antibody responses. The primary PhiX174 antibody response did not differ between the three different genotypes. In contrast, the secondary immune response, expressed as the peak neutralizing titer, was markedly reduced in Lyp/Lyp (9.9+/-3.2; mean value+/-S.E.M. for seven rats) compared to both Lyp/+ (51+/-12; n=13; P=0.006) and +/+ (100+/-20; n=7; P=0.004) BB rats. We suggest that the secondary antibody response to the T cell-dependent neoantigen PhiX174 is linked in a recessive manner to genetic factor(s) in the Lyp gene region.},
  author       = {Clark, L and Greenbaum, C and Jiang, J and Lernmark, Åke and Ochs, H},
  issn         = {2049-632X},
  language     = {eng},
  number       = {3},
  pages        = {205--209},
  publisher    = {Wiley-Blackwell},
  series       = {Pathogens and Disease},
  title        = {The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats.},
  url          = {http://dx.doi.org/10.1111/j.1574-695X.2002.tb00555.x},
  volume       = {32},
  year         = {2002},
}