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Flat colorectal tumours in a south Swedish population: A prospective chromoendoscopic and histopathological study.

Tsuda, S; Veress, Bela LU ; Toth, Ervin LU and Fork, Thomas LU (2002) In Gut 51(4). p.550-555
Abstract
Background: Flat and depressed colorectal tumours are common in Japan but are very rare or non-existent in Western countries.



Aims: To study the occurrence of flat colorectal tumours in a southern Swedish population.



Methods: In this prospective study, 371 consecutive European patients were examined by high resolution video colonoscopy combined with chromoendoscopy. The nature of the lesions was determined by histopathological examination.



Results: A total of 973 tumours were found; 907 (93.2%) were protruding and 66 (6.8%) were flat or depressed. Of the flat/depressed tumours, five (7.7%) were early adenocarcinomas infiltrating the submucosa. Eleven carcinomas (1.2%) were found... (More)
Background: Flat and depressed colorectal tumours are common in Japan but are very rare or non-existent in Western countries.



Aims: To study the occurrence of flat colorectal tumours in a southern Swedish population.



Methods: In this prospective study, 371 consecutive European patients were examined by high resolution video colonoscopy combined with chromoendoscopy. The nature of the lesions was determined by histopathological examination.



Results: A total of 973 tumours were found; 907 (93.2%) were protruding and 66 (6.8%) were flat or depressed. Of the flat/depressed tumours, five (7.7%) were early adenocarcinomas infiltrating the submucosa. Eleven carcinomas (1.2%) were found among protruding tumours. High grade dysplasia was observed in 18% (n=11) of flat/depressed adenomas in contrast with 7.3% (n=65) of protruding adenomas, and occurred in smaller flat/depressed tumours compared with protruding ones (mean diameter 8 mm v 23 mm, respectively). Furthermore, high grade dysplasia was significantly more common in flat elevated tumours with central depression or in depressed adenomas (35.7%; 5/14) than in flat elevated adenomas (12.8%; 6/47).



Conclusion: Flat and depressed tumours exist in a Western population. Future studies should address whether or not chromoendoscopy with video colonoscopy is necessary in the search for flat colorectal neoplasms. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Gut
volume
51
issue
4
pages
550 - 555
publisher
BMJ Publishing Group
external identifiers
  • scopus:0036785362
ISSN
1468-3288
language
English
LU publication?
yes
id
ad3e23cb-c5e4-4a38-b8c9-7ab906bc909c (old id 1124441)
alternative location
http://gut.bmj.com/cgi/content/abstract/51/4/550
date added to LUP
2008-06-03 12:30:13
date last changed
2017-01-29 04:24:32
@article{ad3e23cb-c5e4-4a38-b8c9-7ab906bc909c,
  abstract     = {Background: Flat and depressed colorectal tumours are common in Japan but are very rare or non-existent in Western countries.<br/><br>
<br/><br>
Aims: To study the occurrence of flat colorectal tumours in a southern Swedish population.<br/><br>
<br/><br>
Methods: In this prospective study, 371 consecutive European patients were examined by high resolution video colonoscopy combined with chromoendoscopy. The nature of the lesions was determined by histopathological examination.<br/><br>
<br/><br>
Results: A total of 973 tumours were found; 907 (93.2%) were protruding and 66 (6.8%) were flat or depressed. Of the flat/depressed tumours, five (7.7%) were early adenocarcinomas infiltrating the submucosa. Eleven carcinomas (1.2%) were found among protruding tumours. High grade dysplasia was observed in 18% (n=11) of flat/depressed adenomas in contrast with 7.3% (n=65) of protruding adenomas, and occurred in smaller flat/depressed tumours compared with protruding ones (mean diameter 8 mm v 23 mm, respectively). Furthermore, high grade dysplasia was significantly more common in flat elevated tumours with central depression or in depressed adenomas (35.7%; 5/14) than in flat elevated adenomas (12.8%; 6/47).<br/><br>
<br/><br>
Conclusion: Flat and depressed tumours exist in a Western population. Future studies should address whether or not chromoendoscopy with video colonoscopy is necessary in the search for flat colorectal neoplasms.},
  author       = {Tsuda, S and Veress, Bela and Toth, Ervin and Fork, Thomas},
  issn         = {1468-3288},
  language     = {eng},
  number       = {4},
  pages        = {550--555},
  publisher    = {BMJ Publishing Group},
  series       = {Gut},
  title        = {Flat colorectal tumours in a south Swedish population: A prospective chromoendoscopic and histopathological study.},
  volume       = {51},
  year         = {2002},
}