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Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats.

Mei, Q; Mundinger, TO; Lernmark, Åke LU and Taborsky, GJ Jr. (2002) In Diabetes 51(10). p.2997-3002
Abstract
To discover whether islet sympathetic nerves are damaged during the autoimmune destruction of islet B-cells, we immunostained sections of pancreas from BioBreeder (BB) diabetic rats, using antibodies against vesicular monoamine transporter 2 (VMAT2), a marker of sympathetic nerve terminals. We found a marked decrease in the VMAT2-positive fiber area in the islets of BB rats that had been diabetic for only 1-2 weeks compared with their nondiabetic controls. In contrast, there was no significant decrease in the VMAT2-positive fiber area in the exocrine pancreas in these early diabetic BB rats. Furthermore, streptozotocin-diabetic rats showed no decrease in VMAT2-positive fiber area in their islets compared with controls. The classical... (More)
To discover whether islet sympathetic nerves are damaged during the autoimmune destruction of islet B-cells, we immunostained sections of pancreas from BioBreeder (BB) diabetic rats, using antibodies against vesicular monoamine transporter 2 (VMAT2), a marker of sympathetic nerve terminals. We found a marked decrease in the VMAT2-positive fiber area in the islets of BB rats that had been diabetic for only 1-2 weeks compared with their nondiabetic controls. In contrast, there was no significant decrease in the VMAT2-positive fiber area in the exocrine pancreas in these early diabetic BB rats. Furthermore, streptozotocin-diabetic rats showed no decrease in VMAT2-positive fiber area in their islets compared with controls. The classical diabetic autonomic neuropathy (DAN) that eventually occurs in the heart was not present in BB diabetic rats at this early stage as evidenced by normal cardiac VMAT2 immunostaining and normal cardiac norepinephrine content. Also, in contrast to DAN, this isl (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes
volume
51
issue
10
pages
2997 - 3002
publisher
American Diabetes Association Inc.
external identifiers
  • scopus:0036789177
ISSN
1939-327X
DOI
10.2337/diabetes.51.10.2997
language
English
LU publication?
no
id
1da4aebc-65a5-4bc8-b54c-f25295794d37 (old id 1124793)
alternative location
http://diabetes.diabetesjournals.org/cgi/content/abstract/51/10/2997
date added to LUP
2008-05-27 13:39:48
date last changed
2017-09-07 09:42:02
@article{1da4aebc-65a5-4bc8-b54c-f25295794d37,
  abstract     = {To discover whether islet sympathetic nerves are damaged during the autoimmune destruction of islet B-cells, we immunostained sections of pancreas from BioBreeder (BB) diabetic rats, using antibodies against vesicular monoamine transporter 2 (VMAT2), a marker of sympathetic nerve terminals. We found a marked decrease in the VMAT2-positive fiber area in the islets of BB rats that had been diabetic for only 1-2 weeks compared with their nondiabetic controls. In contrast, there was no significant decrease in the VMAT2-positive fiber area in the exocrine pancreas in these early diabetic BB rats. Furthermore, streptozotocin-diabetic rats showed no decrease in VMAT2-positive fiber area in their islets compared with controls. The classical diabetic autonomic neuropathy (DAN) that eventually occurs in the heart was not present in BB diabetic rats at this early stage as evidenced by normal cardiac VMAT2 immunostaining and normal cardiac norepinephrine content. Also, in contrast to DAN, this isl},
  author       = {Mei, Q and Mundinger, TO and Lernmark, Åke and Taborsky, GJ Jr.},
  issn         = {1939-327X},
  language     = {eng},
  number       = {10},
  pages        = {2997--3002},
  publisher    = {American Diabetes Association Inc.},
  series       = {Diabetes},
  title        = {Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats.},
  url          = {http://dx.doi.org/10.2337/diabetes.51.10.2997},
  volume       = {51},
  year         = {2002},
}